2022
Modafinil does not reduce cocaine use in methadone-maintained individuals
DeVito EE, Poling J, Babuscio T, Nich C, Carroll KM, Sofuoglu M. Modafinil does not reduce cocaine use in methadone-maintained individuals. Drug And Alcohol Dependence Reports 2022, 2: 100032. PMID: 36310662, PMCID: PMC9615926, DOI: 10.1016/j.dadr.2022.100032.Peer-Reviewed Original ResearchCocaine use disorderCocaine use outcomesOpioid useCognitive behavioral therapyContingency managementCocaine dependenceCognitive functionMethadone-maintained individualsUse outcomesEfficacy of modafinilSelf-reported abstinenceTreatment of CUDStimulant-like effectsPlatform treatmentPercentage of urinesPercent of daysDual opioidModafinil treatmentUse disordersPotential efficacyCocaine useModafinilPlaceboMinimal reportsBehavioral therapy
2019
Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
2016
Carvedilol does not reduce cocaine use in methadone-maintained cocaine users
Sofuoglu M, Poling J, Babuscio T, Gonsai K, Severino K, Nich C, Carroll KM. Carvedilol does not reduce cocaine use in methadone-maintained cocaine users. Journal Of Substance Use And Addiction Treatment 2016, 73: 63-69. PMID: 28017186, PMCID: PMC5193370, DOI: 10.1016/j.jsat.2016.11.005.Peer-Reviewed Original ResearchConceptsEfficacy of carvedilolCocaine-positive urinesSignificant group differencesCocaine use disorderCocaine useOpioid usePositive urineGroup differencesOpioid-positive urinesCAR groupMain outcome measuresUrine drug screeningOpioid-dependent participantsSelf-reported drug useSelf-reported daysOverall treatment effectCocaine-dependent participantsTreatment armsAdrenergic blockersTreatment responseOutcome measuresPlaceboWithdrawal severityStudy participationTreatment retention
2012
Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial
Carroll KM, Nich C, Shi JM, Eagan D, Ball SA. Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial. Drug And Alcohol Dependence 2012, 126: 224-231. PMID: 22695473, PMCID: PMC3461119, DOI: 10.1016/j.drugalcdep.2012.05.019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DeterrentsAlcohol DrinkingCocaine-Related DisordersCounselingDemographyDiagnostic and Statistical Manual of Mental DisordersDisulfiramDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleMethadoneNarcoticsOpiate Substitution TreatmentPatient ComplianceRegression AnalysisSelf-Help GroupsSocioeconomic FactorsSubstance Abuse DetectionTreatment OutcomeConceptsMethadone maintenance programEfficacy of disulfiramAlcohol use disorderCocaine useStandard counselingUse disordersCommunity-based methadone maintenance programRandomized placebo-controlled trialPlacebo-controlled trialCurrent alcohol use disorderTwelve-step facilitationCocaine-negative urinesLess cocaine useMethadone maintenanceStep FacilitationCocaine-dependent individualsPlaceboBetter outcomesDisulfiram efficacyTreatment approachesFactorial trialDisulfiramMaintenance programRelative efficacyCocaine users
2006
Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Post-Traumatic Stress Disorder
Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Ralevski E, Rounsaville B. Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Post-Traumatic Stress Disorder. Biological Psychiatry 2006, 60: 777-783. PMID: 17008146, DOI: 10.1016/j.biopsych.2006.03.074.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderAlcohol dependencePsychiatric symptomsComorbid post-traumatic stress disorderVeterans Administration Outpatient ClinicStress disorderAxis I psychiatric disordersBetter alcohol outcomesDouble-blind randomizationOverall psychiatric symptomsDSM-IV criteriaTreatment of alcoholismOpen randomizationActive medicationAdverse eventsAlcohol use outcomesOutpatient clinicGGT levelsMedication studiesPsychiatric disordersSide effectsNaltrexoneAlcohol cravingDrug AdministrationPlacebo
2005
Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders
Petrakis IL, Poling J, Levinson C, Nich C, Carroll K, Rounsaville B, Group V. Naltrexone and Disulfiram in Patients with Alcohol Dependence and Comorbid Psychiatric Disorders. Biological Psychiatry 2005, 57: 1128-1137. PMID: 15866552, DOI: 10.1016/j.biopsych.2005.02.016.Peer-Reviewed Original ResearchConceptsPsychiatric disordersAlcohol dependenceVeterans Administration Outpatient ClinicAxis I psychiatric disordersComorbid psychiatric disordersUse of disulfiramTreatment of alcoholismEvent Monitoring SystemAlcohol-dependent individualsActive medicationAdverse eventsSecondary outcomesPrimary outcomeMedication complianceOutpatient clinicSignificant group differencesGGT levelsMedication studiesPsychiatric symptomsAlcohol consumptionNaltrexoneAlcohol cravingDrug AdministrationConsecutive weeksPlacebo
2004
Efficacy of Disulfiram and Cognitive Behavior Therapy in Cocaine-DependentOutpatients: A Randomized Placebo-Controlled Trial
Carroll KM, Fenton LR, Ball SA, Nich C, Frankforter TL, Shi J, Rounsaville BJ. Efficacy of Disulfiram and Cognitive Behavior Therapy in Cocaine-DependentOutpatients: A Randomized Placebo-Controlled Trial. JAMA Psychiatry 2004, 61: 264-272. PMID: 14993114, PMCID: PMC3675448, DOI: 10.1001/archpsyc.61.3.264.Peer-Reviewed Original ResearchConceptsCocaine useGeneral populationCocaine dependenceEfficacy of disulfiramUrine toxicology screenOutpatient substance abuse treatment programsBehavior therapyConcurrent alcohol useSubstance abuse treatment programsCurrent cocaine dependenceCognitive behavior therapyDisulfiram useRandomized PlaceboDisulfiram therapyMedication complianceToxicology screenIdentical capsulesEffective therapyPlaceboCocaine-dependent individualsSelf-reported frequencyPromising treatmentPlacebo conditionInterpersonal psychotherapyTherapy
1998
Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts
Petrakis I, Carroll K, Nich C, Gordon L, Kosten T, Rounsaville B. Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts. Drug And Alcohol Dependence 1998, 50: 221-226. PMID: 9649975, DOI: 10.1016/s0376-8716(98)00032-5.Peer-Reviewed Original ResearchConceptsCocaine useOpioid addictsMedication effectsDepressive symptomsSignificant decreaseEffectiveness of fluoxetineSelf-reported cocaine useDrug use outcomesSubsample of subjectsFluoxetine treatmentUrine toxicologySelf-reported useDepressive disorderSevere depressionHeroin useFluoxetineEffective agentUse outcomesDepressionPlaceboSignificant differencesTreatmentSymptomsAddictsMethadone
1994
Psychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers
Carroll KM, Rounsaville BJ, Gordon LT, Nich C, Jatlow P, Bisighini RM, Gawin FH. Psychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers. JAMA Psychiatry 1994, 51: 177-187. PMID: 8122955, DOI: 10.1001/archpsyc.1994.03950030013002.Peer-Reviewed Original ResearchConceptsClinical managementCocaine useCocaine abusersRelapse preventionAmbulatory cocaine abusersWeeks of treatmentForm of treatmentHigh-severity patientsInitiation trialsAbstinence initiationBaseline severityClinical trialsEffective treatmentTreatment retentionBetter outcomesCocaine abusePharmacotherapyDepressed subjectsPlaceboDesipramine hydrochlorideSpecialized treatmentDesipraminePreventionGreater reductionDistinct subgroups