1998
Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts
Petrakis I, Carroll K, Nich C, Gordon L, Kosten T, Rounsaville B. Fluoxetine treatment of depressive disorders in methadone-maintained opioid addicts. Drug And Alcohol Dependence 1998, 50: 221-226. PMID: 9649975, DOI: 10.1016/s0376-8716(98)00032-5.Peer-Reviewed Original ResearchConceptsCocaine useOpioid addictsMedication effectsDepressive symptomsSignificant decreaseEffectiveness of fluoxetineSelf-reported cocaine useDrug use outcomesSubsample of subjectsFluoxetine treatmentUrine toxicologySelf-reported useDepressive disorderSevere depressionHeroin useFluoxetineEffective agentUse outcomesDepressionPlaceboSignificant differencesTreatmentSymptomsAddictsMethadone
1997
Variability in treatment-seeking cocaine abusers: implications for clinical pharmacotherapy trials.
Carroll KM, Nich C, Rounsaville BJ. Variability in treatment-seeking cocaine abusers: implications for clinical pharmacotherapy trials. NIDA Research Monograph 1997, 175: 137-57. PMID: 9467796.Peer-Reviewed Original ResearchConceptsPatient-treatment interactionsTreatment responseCocaine abusersClinical pharmacotherapy trialsChallenging patient populationEffective pharmacological interventionsStudy sampleSpecific treatment strategiesTreatment-seeking cocaine abusersPatient populationPharmacotherapy trialsMedication effectsNew medicationsPharmacologic agentsTreatment responsivenessPharmacological interventionsPharmacotherapy researchTreatment strategiesLarger sample sizeCocaine dependenceComparison of findingsTreatment seekingStandardized assessmentSimple main effectsInconsistent findings