2018
Change in DSM‐5 Alcohol Use Disorder Criteria Count and Severity Level as a Treatment Outcome Indicator: Results from a Randomized Trial
Kiluk BD, Frankforter TL, Cusumano M, Nich C, Carroll KM. Change in DSM‐5 Alcohol Use Disorder Criteria Count and Severity Level as a Treatment Outcome Indicator: Results from a Randomized Trial. Alcohol Clinical And Experimental Research 2018, 42: 1556-1563. PMID: 29870051, PMCID: PMC6281805, DOI: 10.1111/acer.13807.Peer-Reviewed Original ResearchAlcohol use disorderRandomized clinical trialsClinical trialsSeverity categoriesOutcome indicatorsDSM criteriaCurrent AUD diagnosisPotential outcome indicatorsTreatment outcome indicatorsWeekly outpatient treatmentMost clinical trialsStructured Clinical InterviewLinear mixed modelsTreatment end pointsCognitive behavioral therapy programCriterion countsMeaningful outcome indicatorsBehavioral therapy programAlcohol use outcomesOutpatient treatmentTrend-level significanceMain trialDiagnostic criteriaUse disordersBetter outcomes
2014
Computer-Assisted Delivery of Cognitive-Behavioral Therapy: Efficacy and Durability of CBT4CBT Among Cocaine-Dependent Individuals Maintained on Methadone
Carroll KM, Kiluk BD, Nich C, Gordon MA, Portnoy GA, Marino DR, Ball SA. Computer-Assisted Delivery of Cognitive-Behavioral Therapy: Efficacy and Durability of CBT4CBT Among Cocaine-Dependent Individuals Maintained on Methadone. American Journal Of Psychiatry 2014, 171: 436-444. PMID: 24577287, PMCID: PMC4042674, DOI: 10.1176/appi.ajp.2013.13070987.Peer-Reviewed Original ResearchConceptsCocaine-dependent individualsCognitive behavioral therapyMethadone maintenanceCommunity-based outpatient clinicsPrevious pilot trialMethadone maintenance programStandard methadone maintenanceDisseminable strategyDefinitive trialOutpatient clinicClinical trialsEffective adjunctPilot trialTreatment terminationTreatment retentionBetter outcomesConsecutive weeksCBT4CBTWeekly accessAddiction treatmentDurable effectsTrialsSubstance usersStatistical significanceMethadone
2012
Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial
Carroll KM, Nich C, Shi JM, Eagan D, Ball SA. Efficacy of disulfiram and Twelve Step Facilitation in cocaine-dependent individuals maintained on methadone: A randomized placebo-controlled trial. Drug And Alcohol Dependence 2012, 126: 224-231. PMID: 22695473, PMCID: PMC3461119, DOI: 10.1016/j.drugalcdep.2012.05.019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DeterrentsAlcohol DrinkingCocaine-Related DisordersCounselingDemographyDiagnostic and Statistical Manual of Mental DisordersDisulfiramDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleMethadoneNarcoticsOpiate Substitution TreatmentPatient ComplianceRegression AnalysisSelf-Help GroupsSocioeconomic FactorsSubstance Abuse DetectionTreatment OutcomeConceptsMethadone maintenance programEfficacy of disulfiramAlcohol use disorderCocaine useStandard counselingUse disordersCommunity-based methadone maintenance programRandomized placebo-controlled trialPlacebo-controlled trialCurrent alcohol use disorderTwelve-step facilitationCocaine-negative urinesLess cocaine useMethadone maintenanceStep FacilitationCocaine-dependent individualsPlaceboBetter outcomesDisulfiram efficacyTreatment approachesFactorial trialDisulfiramMaintenance programRelative efficacyCocaine users
2004
Sex differences in cocaine-dependent individuals' response to disulfiram treatment
Nich C, McCance-Katz EF, Petrakis IL, Cubells JF, Rounsaville BJ, Carroll KM. Sex differences in cocaine-dependent individuals' response to disulfiram treatment. Addictive Behaviors 2004, 29: 1123-1128. PMID: 15236812, PMCID: PMC3680597, DOI: 10.1016/j.addbeh.2004.03.004.Peer-Reviewed Original ResearchConceptsDisulfiram treatmentDopamine-mediated responsesDrug-free urine specimensRandomized clinical trialsCocaine-dependent subjectsSex-based responsesDays of abstinenceSex differencesPrimary outcomeClinical trialsTreatment interactionUrine specimensBetter outcomesCocaine dependenceAlcohol useIntermediate outcomesDisulfiramSexOutcomesTreatmentSignificant sexIndividual responsesPossible mechanismResponseDifferential responseMillon Clinical Multiaxial Inventory-III Subtypes of Opioid Dependence: Validity and Matching to Behavioral Therapies
Ball SA, Nich C, Rounsaville BJ, Eagan D, Carroll KM. Millon Clinical Multiaxial Inventory-III Subtypes of Opioid Dependence: Validity and Matching to Behavioral Therapies. Journal Of Consulting And Clinical Psychology 2004, 72: 698-711. PMID: 15301655, PMCID: PMC3709250, DOI: 10.1037/0022-006x.72.4.698.Peer-Reviewed Original ResearchConceptsLess symptom improvementOpioid-dependent outpatientsOpioid dependenceSymptom improvementClinical trialsBetter outcomesPredictive validity analysesBehavioral therapyVoucher conditionSubtypesAffective disturbancesIntervention conditionMatching AnalysisPredictive validityCounselingValidity analysisNaltrexoneGroup counselingOutpatientsTherapyTrials
2000
One‐year follow‐up of disulfiram and psychotherapy for cocaine‐alcohol users: sustained effects of treatment
Carroll K, Nich C, Ball S, McCance E, Frankforter T, Rounsaville B. One‐year follow‐up of disulfiram and psychotherapy for cocaine‐alcohol users: sustained effects of treatment. Addiction 2000, 95: 1335-1349. PMID: 11048353, DOI: 10.1046/j.1360-0443.2000.95913355.x.Peer-Reviewed Original ResearchConceptsCognitive-behavioral treatmentTwelve-step facilitationInitiation of abstinenceAlcohol useSubstance abuse treatment centersFrequency of cocaineAlcohol-dependent individualsClinical managementMain effectBrief treatmentEfficacy of disulfiramUrine toxicology screenCessation of treatmentBreathalyzer testEnd of treatmentOutcomes 1 yearAbstinencePercentage of daysEffect of treatmentCocaineLong-term benefitsToxicology screenTreatment centersBetter outcomesBrief period
1994
Psychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers
Carroll KM, Rounsaville BJ, Gordon LT, Nich C, Jatlow P, Bisighini RM, Gawin FH. Psychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers. JAMA Psychiatry 1994, 51: 177-187. PMID: 8122955, DOI: 10.1001/archpsyc.1994.03950030013002.Peer-Reviewed Original ResearchConceptsClinical managementCocaine useCocaine abusersRelapse preventionAmbulatory cocaine abusersWeeks of treatmentForm of treatmentHigh-severity patientsInitiation trialsAbstinence initiationBaseline severityClinical trialsEffective treatmentTreatment retentionBetter outcomesCocaine abusePharmacotherapyDepressed subjectsPlaceboDesipramine hydrochlorideSpecialized treatmentDesipraminePreventionGreater reductionDistinct subgroups