Binding, folding and insertion of a β-hairpin peptide at a lipid bilayer surface: Influence of electrostatics and lipid tail packing
Reid KA, Davis CM, Dyer RB, Kindt JT. Binding, folding and insertion of a β-hairpin peptide at a lipid bilayer surface: Influence of electrostatics and lipid tail packing. Biochimica Et Biophysica Acta (BBA) - Biomembranes 2017, 1860: 792-800. PMID: 29291379, PMCID: PMC5780206, DOI: 10.1016/j.bbamem.2017.12.019.Peer-Reviewed Original ResearchConceptsΒ-hairpin peptidesSVS-1POPC/POPG bilayersPOPC bilayersAtomistic molecular dynamics simulationsLipid bilayersInfluence of electrostaticsLipid bilayer surfaceMolecular dynamics simulationsCircular dichroism studiesCHARMM C36DPPG lipidsMixture of DPPCPOPG bilayersSpectroscopic studiesTail packingBilayer surfaceHydrophobic interactionsForce fieldHeadgroup packingTransient foldingDPPC bilayersDichroism studiesDynamics simulationsFluorescent peptides