2024
Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder
Roos C, Kiluk B, Carroll K, Bricker J, Mun C, Sala M, Kirouac M, Stein E, John M, Palmer R, DeBenedictis A, Frisbie J, Haeny A, Barry D, Fucito L, Bowen S, Witkiewitz K, Kober H. Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder. Annals Of Medicine 2024, 56: 2315228. PMID: 38382111, PMCID: PMC10883107, DOI: 10.1080/07853890.2024.2315228.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory CareHumansMindfulnessMobile ApplicationsMotivationSubstance-Related DisordersConceptsSubstance use disordersMindfulness-based interventionsPhone coachingQualitative feedbackPromote recoveryEvidence of feasibilityUse disorderPhase 2Promote long-term recoveryApp featuresUnmet needsAdjunctive interventionTen adultsSmartphone appLong-term recoveryInterventionTherapy videosMindfulness practiceParticipantsOutpatient treatmentMind toolPhase 1CoachingAcceptance dimensionQuantitative ratings
2023
Distinct neural networks predict cocaine versus cannabis treatment outcomes
Lichenstein S, Kohler R, Ye F, Potenza M, Kiluk B, Yip S. Distinct neural networks predict cocaine versus cannabis treatment outcomes. Molecular Psychiatry 2023, 28: 3365-3372. PMID: 37308679, PMCID: PMC10713861, DOI: 10.1038/s41380-023-02120-0.Peer-Reviewed Original ResearchMeSH KeywordsCannabisCocaineCocaine-Related DisordersCognitive Behavioral TherapyHumansMaleOpioid-Related DisordersSubstance-Related DisordersTreatment OutcomeConceptsConnectome-based predictive modelingCognitive behavior therapyCognitive behavioral therapySubstance use disordersCannabis abstinenceNeural mechanismsBehavior therapyDistinct neural networksComputer-based trainingCannabis use disorderFMRI scanningNeural predictorsStudy 1Study 2Treatment outcomesContingency managementPrior workComparison subjectsNetwork strengthUse disordersNovel treatment targetsAbstinenceIndependent samplesCocaine abstinenceTreatment respondersPercentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use
Loya J, Babuscio T, Nich C, Alessi S, Rash C, Kiluk B. Percentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use. Drug And Alcohol Dependence 2023, 248: 109947. PMID: 37276806, PMCID: PMC10498479, DOI: 10.1016/j.drugalcdep.2023.109947.Peer-Reviewed Original ResearchConceptsUrine drug screensClinical trialsMeaningful endpointsCocaine useLong-term clinical benefitBetter long-term outcomesDrug screensPsychosocial functioningNegative urine drug screensLong-term outcomesRandomized clinical trialsFuture clinical trialsBetter psychosocial functioningClinical benefitPharmacological treatmentContinuous abstinenceTreatment periodTreatment respondersSustained abstinenceSubstance useTrialsTreatmentMeaningful thresholdPooled datasetAbstinence
2021
Cognitive-Behavioral Interventions Targeting Alcohol or Other Drug Use and Co-Occurring Mental Health Disorders: A Meta-Analysis
Mehta K, Hoadley A, Ray LA, Kiluk BD, Carroll KM, Magill M. Cognitive-Behavioral Interventions Targeting Alcohol or Other Drug Use and Co-Occurring Mental Health Disorders: A Meta-Analysis. Alcohol And Alcoholism 2021, 56: 535-544. PMID: 33778869, PMCID: PMC8406071, DOI: 10.1093/alcalc/agab016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCognitive Behavioral TherapyFemaleHumansMaleMental DisordersMiddle AgedRandomized Controlled Trials as TopicSubstance-Related DisordersYoung AdultConceptsCognitive-behavioral interventionsMental health disordersCo-occurring mental health disordersHealth disordersDrug useEffect sizeDrug use disordersSignificant residual heterogeneityHigh-quality studiesMental health symptomsPost-traumatic stress disorderUnderstanding of treatmentMeta-regression modelsClinical trialsStudy qualityPromising effect sizesUse disordersStudy heterogeneityMHD diagnosisHealth symptomsMeta-AnalysisStress disorderAlcohol useTime pointsSmall effect sizes
2020
Combined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders
Ray LA, Meredith LR, Kiluk BD, Walthers J, Carroll KM, Magill M. Combined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders. JAMA Network Open 2020, 3: e208279. PMID: 32558914, PMCID: PMC7305524, DOI: 10.1001/jamanetworkopen.2020.8279.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyDrug Therapy, CombinationFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicSubstance-Related DisordersTreatment OutcomeConceptsSubstance use disordersAdult alcohol use disordersCognitive behavioral therapyUsual careRandomized clinical trialsUse disordersBehavioral therapySpecific therapyClinical trialsAddition of CBTSuperiority of CBTTreatment of SUDsUsual clinical managementForms of pharmacotherapyFirst-line interventionEvidence-based therapiesClinical trial samplesEvidence-based modalitiesAlcohol use disorderEnglish-language articlesPublic health concernFull-text articlesEffect sizeCochrane RegisterRandom effects estimatesThe search for mechanisms of cognitive behavioral therapy for alcohol or other drug use disorders: A systematic review
Magill M, Tonigan JS, Kiluk B, Ray L, Walthers J, Carroll K. The search for mechanisms of cognitive behavioral therapy for alcohol or other drug use disorders: A systematic review. Behaviour Research And Therapy 2020, 131: 103648. PMID: 32474226, PMCID: PMC7329023, DOI: 10.1016/j.brat.2020.103648.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDrug use disordersUse disordersSystematic reviewBehavioral therapyRandomized clinical trialsStudy inclusion criteriaPatient behavior changeCBT-based treatmentClinical trialsInclusion criteriaStatistical mediatorMediator candidatesIntervention ingredientsProject MATCHCBT mechanismsTherapyBehavior change frameworkMediatorsBehavior changeDisordersAddiction researchReportReviewReview sampleShort- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders
Roos CR, Carroll KM, Nich C, Frankforter T, Kiluk BD. Short- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders. Drug And Alcohol Dependence 2020, 212: 108044. PMID: 32422538, PMCID: PMC7293942, DOI: 10.1016/j.drugalcdep.2020.108044.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultCognitive Behavioral TherapyFemaleHumansMaleMiddle AgedSubstance-Related DisordersTherapy, Computer-AssistedTime FactorsTreatment OutcomeConceptsCognitive behavioral therapyComputerized cognitive behavioral therapyPerson cognitive-behavioural therapySubstance use disordersMediation effectAlcohol use disorderComputer-delivered cognitive behavioural therapyUse disordersSame mediation effectSubstance-related copingCoping Strategies ScaleSignificant mediation effectMechanisms of changeMediational modelCoping skillsStrategies ScaleCBT4CBTStatistical mediatorCopingDrug use disordersSubstance useHeavy drinkingDisordersLong-term changesLong-term increaseInitial testing of a computer-based simulation training module to support clinicians' acquisition of CBT skills for substance use disorder treatment
Mastroleo NR, Humm L, Williams CM, Kiluk BD, Hoadley A, Magill M. Initial testing of a computer-based simulation training module to support clinicians' acquisition of CBT skills for substance use disorder treatment. Journal Of Substance Use And Addiction Treatment 2020, 114: 108014. PMID: 32527511, PMCID: PMC7361509, DOI: 10.1016/j.jsat.2020.108014.Peer-Reviewed Original ResearchMeSH KeywordsCognitive Behavioral TherapyComputersHumansMotivational InterviewingSimulation TrainingSubstance-Related Disorders
2019
Changes in DSM criteria following a culturally-adapted computerized CBT for Spanish-speaking individuals with substance use disorders
Silva MA, Jaramillo Y, Paris M, Añez-Nava L, Frankforter TL, Kiluk BD. Changes in DSM criteria following a culturally-adapted computerized CBT for Spanish-speaking individuals with substance use disorders. Journal Of Substance Use And Addiction Treatment 2019, 110: 42-48. PMID: 31952627, PMCID: PMC6981257, DOI: 10.1016/j.jsat.2019.12.006.Peer-Reviewed Original ResearchMeSH KeywordsCognitive Behavioral TherapyDiagnostic and Statistical Manual of Mental DisordersHumansSubstance-Related DisordersTherapy, Computer-AssistedTreatment OutcomeConceptsSubstance use disordersAddiction Severity IndexUse disordersDSM criteriaStructured Clinical InterviewDSM-IV substance dependenceMeaningful outcomesDiagnostic statusTimeline followback methodStatistical Manual criteriaCognitive behavioral therapy programBehavioral therapy programSubstance use outcomesProblem severityDSM-IV dependence criteriaPrimary outcomeUrine toxicologyLower problem severityClinical trialsTreatment periodMain trialOutpatient counselingClinical InterviewSecondary analysisDSM-IVA Meta-Analysis of Cognitive-Behavioral Therapy for Alcohol or Other Drug Use Disorders: Treatment Efficacy by Contrast Condition
Magill M, Ray L, Kiluk B, Hoadley A, Bernstein M, Tonigan JS, Carroll K. A Meta-Analysis of Cognitive-Behavioral Therapy for Alcohol or Other Drug Use Disorders: Treatment Efficacy by Contrast Condition. Journal Of Consulting And Clinical Psychology 2019, 87: 1093-1105. PMID: 31599606, PMCID: PMC6856400, DOI: 10.1037/ccp0000447.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismCognitive Behavioral TherapyHumansOutcome Assessment, Health CareSubstance-Related DisordersConceptsCognitive behavioral therapyDrug use disordersUse disordersEffect sizeConsumption frequencyTime pointsEvidence-based therapiesPooled effect sizeMinimal treatmentEstimates of efficacyTest of heterogeneityCBT effectsNonspecific therapySpecific therapySuperior efficacyStudy-level moderatorsModerate heterogeneityTreatment efficacySignificant effect sizeMultivariate analysisMeta-AnalysisTherapyPublication biasStudy aimNonspecific control
2018
Response to commentaries: The quest(ion) remains in the search for a meaningful reduction‐based end‐point
Kiluk BD, Fitzmaurice GM, Strain EC, Weiss RD. Response to commentaries: The quest(ion) remains in the search for a meaningful reduction‐based end‐point. Addiction 2018, 114: 21-23. PMID: 30474162, PMCID: PMC6357767, DOI: 10.1111/add.14491.Peer-Reviewed Original ResearchHumansSubstance-Related DisordersCulturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial.
Paris M, Silva M, Añez-Nava L, Jaramillo Y, Kiluk BD, Gordon MA, Nich C, Frankforter T, Devore K, Ball SA, Carroll KM. Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial. American Journal Of Public Health 2018, 108: 1535-1542. PMID: 30252519, PMCID: PMC6187780, DOI: 10.2105/ajph.2018.304571.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyConnecticutCulturally Competent CareFemaleHispanic or LatinoHumansInternetMaleSubstance-Related DisordersTreatment OutcomeConceptsSubstance use disordersCognitive-behavioral treatmentUse disordersSubstance use outcomesClinical trialsWeb-based cognitive behavioral therapyCurrent substance use disorderUse outcomesRandomized clinical trialsStandard outpatient treatmentEvidence-based treatmentsCognitive behavioral therapyPrimary outcomeStandard treatmentOutpatient treatmentStandard outpatientTreatment completionHealth disparitiesBehavioral therapyBehavioral treatmentAddiction treatmentTreatment-seeking individualsGreater reductionTreatmentDisordersWhat defines a clinically meaningful outcome in the treatment of substance use disorders: reductions in direct consequences of drug use or improvement in overall functioning?
Kiluk BD, Fitzmaurice GM, Strain EC, Weiss RD. What defines a clinically meaningful outcome in the treatment of substance use disorders: reductions in direct consequences of drug use or improvement in overall functioning? Addiction 2018, 114: 9-15. PMID: 29900624, PMCID: PMC6289694, DOI: 10.1111/add.14289.Peer-Reviewed Original ResearchConceptsSubstance use disordersDrug useUse disordersMost substance use disordersTreatment Efficacy TrialMeaningful outcomesOverall functioningException of alcoholAlcohol-related consequencesAspects of functioningPharmacotherapy trialsEfficacy trialsHealth consequencesIndividual functioningTrialsLong-term functioningWeak associationDisordersCurrent standardFunctioningUse trialOutcomesAssociationAbstinenceRandomized Clinical Trial of Computerized and Clinician-Delivered CBT in Comparison With Standard Outpatient Treatment for Substance Use Disorders: Primary Within-Treatment and Follow-Up Outcomes
Kiluk BD, Nich C, Buck MB, Devore KA, Frankforter TL, LaPaglia DM, Muvvala SB, Carroll KM. Randomized Clinical Trial of Computerized and Clinician-Delivered CBT in Comparison With Standard Outpatient Treatment for Substance Use Disorders: Primary Within-Treatment and Follow-Up Outcomes. American Journal Of Psychiatry 2018, 175: 853-863. PMID: 29792052, PMCID: PMC6120780, DOI: 10.1176/appi.ajp.2018.17090978.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory CareCognitive Behavioral TherapyFemaleFollow-Up StudiesHumansMaleSubstance-Related DisordersTherapy, Computer-AssistedTreatment OutcomeConceptsCognitive behavioral therapySubstance use disordersComputer-based cognitive behavioral therapyUse disordersMinimal clinical monitoringTreatment-seeking populationTreatment-seeking outpatientsDSM-IV-TR criteriaCBT groupFrequency of substanceStandard outpatient careCBT4CBTStand-alone treatmentDiverse sampleStandard outpatient treatmentCurrent substance use disorderBehavioral conceptsBetter learningSubstance abuseHeterogeneous sampleUp OutcomesHigh dropout ratePrevious trialsSix-month followClinical trials
2017
Cognitive Behavioral Interventions for Alcohol and Drug Use Disorders: Through the Stage Model and Back Again
Carroll KM, Kiluk BD. Cognitive Behavioral Interventions for Alcohol and Drug Use Disorders: Through the Stage Model and Back Again. Psychology Of Addictive Behaviors 2017, 31: 847-861. PMID: 28857574, PMCID: PMC5714654, DOI: 10.1037/adb0000311.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapy approachStage modelAlcohol use disorderCognitive scienceCBT interventionLarge evidence baseModest effect sizesAddictive disordersCore featuresCBTEmpirical supportMental healthImplementation cliffPowerful interventionUse disordersNovel settingStatic interventionsEffect sizeTreatment of drugAddictionTherapy approachesDurable effectsInterventionEvidence basePsychology
2016
Performance-Based Contingency Management in Cognitive Remediation Training: A Pilot Study
Kiluk BD, Buck MB, Devore KA, Babuscio TA, Nich C, Carroll KM. Performance-Based Contingency Management in Cognitive Remediation Training: A Pilot Study. Journal Of Substance Use And Addiction Treatment 2016, 72: 80-88. PMID: 27590364, PMCID: PMC5154814, DOI: 10.1016/j.jsat.2016.08.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive DysfunctionCognitive RemediationFemaleHumansMaleMiddle AgedOutcome Assessment, Health CarePilot ProjectsRewardSubstance-Related DisordersConceptsCognitive remediation trainingRemediation trainingCR trainingCR taskCognitive remediation interventionsTest Part BNeuropsychological assessment batterySUD treatment outcomesNeuropsychological assessment measuresContingency management proceduresFour-week interventionRecall taskDays of abstinenceExecutive functionRemediation interventionsLevel of engagementMild cognitive impairmentAssessment BatteryContingency managementDifferential improvementSession attendanceAssessment measuresCognitive impairmentSubstance usersOutpatient substancePatient Pre-Treatment Expectations Do Not Predict Cocaine Use Outcomes: Data From Four Clinical Trials
Serafini K, Kiluk BD, Babuscio T, Carroll KM. Patient Pre-Treatment Expectations Do Not Predict Cocaine Use Outcomes: Data From Four Clinical Trials. Substance Use & Misuse 2016, 51: 1484-1492. PMID: 27356306, PMCID: PMC4986687, DOI: 10.1080/10826084.2016.1188945.Peer-Reviewed Original Research
2015
Measures of outcome for stimulant trials: ACTTION recommendations and research agenda
Kiluk BD, Carroll KM, Duhig A, Falk DE, Kampman K, Lai S, Litten RZ, McCann DJ, Montoya ID, Preston KL, Skolnick P, Weisner C, Woody G, Chandler R, Detke MJ, Dunn K, Dworkin RH, Fertig J, Gewandter J, Moeller FG, Ramey T, Ryan M, Silverman K, Strain EC. Measures of outcome for stimulant trials: ACTTION recommendations and research agenda. Drug And Alcohol Dependence 2015, 158: 1-7. PMID: 26652899, PMCID: PMC4698050, DOI: 10.1016/j.drugalcdep.2015.11.004.Peer-Reviewed Original ResearchMeSH KeywordsAmphetamine-Related DisordersCentral Nervous System StimulantsClinical Trials as TopicCongresses as TopicHumansPractice Guidelines as TopicSubstance-Related DisordersTreatment OutcomeConceptsStimulant use disorderClinical trialsMeaningful outcome measuresUse disordersTreatment successOutcome measuresStimulant abstinenceAddiction Clinical Trial TranslationsFuture clinical trialsClinical trial endpointsClinical trial dataAlcohol use disorderMeasures of outcomeValidation of PatientStimulant trialsTrial endpointsEfficacious pharmacotherapiesUrine testingSustained abstinenceTrial dataSecondary analysisStimulant useTrialsPsychosocial benefitsDisordersOutcome expectations and associated treatment outcomes in motivational enhancement therapy delivered in English and Spanish
Serafini K, Decker S, Kiluk BD, Añez L, Paris M, Frankforter T, Carroll KM. Outcome expectations and associated treatment outcomes in motivational enhancement therapy delivered in English and Spanish. American Journal On Addictions 2015, 24: 732-739. PMID: 26541501, PMCID: PMC4885684, DOI: 10.1111/ajad.12301.Peer-Reviewed Original ResearchMeSH KeywordsAcculturationAdolescentAdultAttitudeFemaleHispanic or LatinoHumansLanguageMaleMotivationMotivational InterviewingSubstance-Related DisordersTreatment OutcomeYoung AdultConceptsPatients' outcome expectationsTreatment outcomesMotivational enhancement therapyEnhancement therapyUrine toxicology screenLikelihood of abstinenceSubstance use disordersSubstance use outcomesToxicology screenClinical trialsTreatment periodUse disordersOutcome expectationsSecondary analysisSubstance useAbstinenceUse outcomesOutcomesMetSTherapyTreatmentBaseline expectationsGreater percentageSame treatmentImportant predictor
2013
New Developments in Behavioral Treatments for Substance Use Disorders
Kiluk BD, Carroll KM. New Developments in Behavioral Treatments for Substance Use Disorders. Current Psychiatry Reports 2013, 15: 420. PMID: 24173656, PMCID: PMC3878068, DOI: 10.1007/s11920-013-0420-1.Peer-Reviewed Original ResearchBehavior TherapyCell PhoneDelivery of Health CareEvidence-Based MedicineHumansInternetSecondary PreventionSubstance-Related Disorders