Promoting Race and Ethnic Diversity in a Hospital-Based Randomized Clinical Trial to Address Untreated Alcohol Use Disorder: Initial Lessons Learned.
Edelman E, Frankforter T, Rojas-Perez O, Ablondi K, Castro C, Corvino J, Garcia I, Gordon D, Jaramillo Y, Johnson N, Jordan A, Nich C, Paris M, Pagano D, Weimer M, Williams E, Kiluk B. Promoting Race and Ethnic Diversity in a Hospital-Based Randomized Clinical Trial to Address Untreated Alcohol Use Disorder: Initial Lessons Learned. Journal Of Addiction Medicine 2024 PMID: 39514895, DOI: 10.1097/adm.0000000000001400.Peer-Reviewed Original ResearchAlcohol use disorderBrief Negotiation InterviewUntreated alcohol use disorderUse disorderSocial determinants of healthCognitive behavioral therapyElectronic medical record dataDeterminants of healthEthnically diverse sampleMedical record dataMonths of recruitmentBehavioral therapyModifications-EnhancedReporting AdaptationsTreatment engagementEffectiveness of strategiesSocial determinantsInitiation of medicationRecruitment approachesDiverse samplePost-hospitalizationAlcohol useResearch staffParent trialRecord dataImprovement in coping skills from culturally-adapted digital CBT for Spanish-speaking Hispanics with substance use disorder: Secondary analysis of a randomized clinical trial
Benitez B, Loya J, Jaramillo Y, Muro-Rodriguez N, Rojas Perez O, Nich C, Frankforter T, Paris M, Kiluk B. Improvement in coping skills from culturally-adapted digital CBT for Spanish-speaking Hispanics with substance use disorder: Secondary analysis of a randomized clinical trial. Journal Of Substance Use And Addiction Treatment 2024, 168: 209536. PMID: 39374899, DOI: 10.1016/j.josat.2024.209536.Peer-Reviewed Original ResearchMechanisms of cognitive behavioral therapyQuality of coping skillsCognitive behavioral therapySubstance use disordersPrimary substance useCoping skillsSubstance useCBT programOutpatient treatmentWeeks of outpatient treatmentDigital cognitive behavioral therapyMechanisms of behavior changeWithin-person increasesDaily substance useAdaptive coping skillsSecondary analysis of clinical trial dataTreatment mechanismsRandomized to 8Associated with reductionsBehavioral therapyAnalysis of clinical trial dataUse disorderGeneralizability of researchSecondary analysisSpanish-speaking Hispanic adultsA Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder
Kiluk B, Benitez B, DeVito E, Frankforter T, LaPaglia D, O’Malley S, Nich C. A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder. JAMA Network Open 2024, 7: e2435205. PMID: 39325452, PMCID: PMC11428014, DOI: 10.1001/jamanetworkopen.2024.35205.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDigital cognitive behavioral therapyAlcohol use disorderAlcohol useCBT programUse disorderCognitive behavioral therapy programCurrent alcohol use disorderTreatment-seeking adultsBehavioral therapy programEvidence-based treatmentsBaseline to 6-month follow-upRates of alcohol useReducing alcohol useTreatment periodRandomized clinical trialsBehavioral therapyOutpatient substancePercentage of daysOutpatient treatmentIntention-to-treat analysisIndividual counselingStudy periodFollow-upIntention-to-treatMeasurement invariance of the Perceived Stress Scale across race, sex, and time, and differential impacts on cocaine use treatment outcomes
Schick M, Kiluk B, Nich C, LaPaglia D, Haeny A. Measurement invariance of the Perceived Stress Scale across race, sex, and time, and differential impacts on cocaine use treatment outcomes. Journal Of Substance Use And Addiction Treatment 2024, 166: 209493. PMID: 39151798, PMCID: PMC11392621, DOI: 10.1016/j.josat.2024.209493.Peer-Reviewed Original ResearchCocaine use disorderPerceived Stress ScaleTreatment retentionMeasurement invarianceTreatment outcomesSubstance use treatment outcomesStress ScalePredicting treatment retentionSelf-efficacyCoping self-efficacyTwo-factor modelInfluence treatment outcomeCocaine abuse/dependenceDSM-IVUse disorderCocaine useBetween-group differencesMetric invarianceScalar invarianceTwo-factorCocainePharmacological treatmentFactor analysisDifferential impactAbuse/dependenceA smartphone app-based mindfulness intervention to enhance recovery from substance use disorders: Protocol for a pilot feasibility randomized controlled trial
Roos C, Bricker J, Kiluk B, Trull T, Bowen S, Witkiewitz K, Kober H. A smartphone app-based mindfulness intervention to enhance recovery from substance use disorders: Protocol for a pilot feasibility randomized controlled trial. Contemporary Clinical Trials Communications 2024, 41: 101338. PMID: 39233850, PMCID: PMC11372603, DOI: 10.1016/j.conctc.2024.101338.Peer-Reviewed Original ResearchTreatment-as-usualSubstance use disordersRecovery outcomesLong-term recovery outcomesFeasibility of study proceduresFeasibility randomized controlled trialMindfulness-based treatmentsUse disorderRandomized controlled trialsEcological momentary assessmentIn-personMindfulness interventionPilot trialStudy proceduresControlled trialsMomentary assessmentPublic healthEnhanced recoveryOutpatient treatmentMechanical variablesOutcomesTrialsAppsDelivery methodsIndividualsT166 Treatment Outcomes From Computerized CBT for Substance Use Disorders Among People With Criminal Justice Involvement
Loya J, Babuscio T, Nich C, Kiluk B. T166 Treatment Outcomes From Computerized CBT for Substance Use Disorders Among People With Criminal Justice Involvement. Drug And Alcohol Dependence 2024, 260: 110615. DOI: 10.1016/j.drugalcdep.2023.110615.Peer-Reviewed Original ResearchStructural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment
McCurdy L, DeVito E, Loya J, Nich C, Zhai Z, Kiluk B, Potenza M. Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment. Drug And Alcohol Dependence Reports 2024, 11: 100246. PMID: 38966567, PMCID: PMC11222934, DOI: 10.1016/j.dadr.2024.100246.Peer-Reviewed Original ResearchCocaine use disorderCognitive behavioral therapyCocaine useBehavioral therapyBrain changesBrain structuresWhole-brain voxel-based morphometry analysisCocaine use disorder treatmentLevel of cocaine useWeeks of outpatient treatmentVoxel-based morphometry analysisDigital cognitive behavioral therapyT1-weighted magnetic resonance imaging scansRight caudate bodyAssociated with cocaine useMethadone-maintained individualsGray matter volumeStructural brain changesFunction of engagementCaudate bodyRight caudateCUD treatmentMatter volumeUse disorderBilateral cerebellumExamining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence
Votaw V, Tuchman F, Roos C, Hebden H, McKay J, Kiluk B, Witkiewitz K. Examining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence. Journal Of Substance Use And Addiction Treatment 2024, 163: 209394. PMID: 38735481, PMCID: PMC11180556, DOI: 10.1016/j.josat.2024.209394.Peer-Reviewed Original ResearchCocaine use disorderCocaine useAssociated with less cocaine useTelephone-based continuing careLevel of cocaine useFollow-upDrug use consequencesAssociated with lower levelsClinical trialsBaseline to 12-month follow-upCocaine dependenceTreatment entryProblem severityUse disorderTimeline FollowbackCocaineInitial treatment phaseAbstinenceLow-frequency useLong-term functional outcomeEffect sizeTreatment phaseLong-term outcomesRandomized clinical trialsNegative consequencesUnderstanding the patient and supporter journey in cocaine use disorder
Leclair D, Waye K, Gomez-Mancilla B, Kiluk B, Karanam A, Banerjee P, Muthusamy V, Maahs S. Understanding the patient and supporter journey in cocaine use disorder. Frontiers In Psychiatry 2024, 15: 1230626. PMID: 38659460, PMCID: PMC11040082, DOI: 10.3389/fpsyt.2024.1230626.Peer-Reviewed Original ResearchPatient perspectives on current and potential therapies and clinical trial approaches for cocaine use disorder
Maahs S, Leclair D, Gomez-Mancilla B, Kiluk B, Muthusamy V, Banerjee P, Dasgupta S, Waye K. Patient perspectives on current and potential therapies and clinical trial approaches for cocaine use disorder. Frontiers In Psychiatry 2024, 15: 1230699. PMID: 38487570, PMCID: PMC10937549, DOI: 10.3389/fpsyt.2024.1230699.Peer-Reviewed Original ResearchCocaine use disorderLong-term abstinenceSubstance use disordersBarriers to therapyWithdrawal symptomsUse disorderCraving controlClinical trialsCocaineClinical trial approachesDesign of clinical trialsCravingScreening questionnaireDisordersClinical trial outcomesTrial outcomesPerspectives of individualsRemissionParticipantsDrug seekersPotential therapiesTherapyIndividualsRecruited participantsAbstinenceDevelopment and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder
Roos C, Kiluk B, Carroll K, Bricker J, Mun C, Sala M, Kirouac M, Stein E, John M, Palmer R, DeBenedictis A, Frisbie J, Haeny A, Barry D, Fucito L, Bowen S, Witkiewitz K, Kober H. Development and initial testing of mindful journey: a digital mindfulness-based intervention for promoting recovery from Substance use disorder. Annals Of Medicine 2024, 56: 2315228. PMID: 38382111, PMCID: PMC10883107, DOI: 10.1080/07853890.2024.2315228.Peer-Reviewed Original ResearchConceptsSubstance use disordersMindfulness-based interventionsPhone coachingQualitative feedbackPromote recoveryEvidence of feasibilityUse disorderPhase 2Promote long-term recoveryApp featuresUnmet needsAdjunctive interventionTen adultsSmartphone appLong-term recoveryInterventionTherapy videosMindfulness practiceParticipantsOutpatient treatmentMind toolPhase 1CoachingAcceptance dimensionQuantitative ratings