2017
Neurogenetic analysis of childhood disintegrative disorder
Gupta AR, Westphal A, Yang DYJ, Sullivan CAW, Eilbott J, Zaidi S, Voos A, Vander Wyk BC, Ventola P, Waqar Z, Fernandez TV, Ercan-Sencicek AG, Walker MF, Choi M, Schneider A, Hedderly T, Baird G, Friedman H, Cordeaux C, Ristow A, Shic F, Volkmar FR, Pelphrey KA. Neurogenetic analysis of childhood disintegrative disorder. Molecular Autism 2017, 8: 19. PMID: 28392909, PMCID: PMC5379515, DOI: 10.1186/s13229-017-0133-0.Peer-Reviewed Original ResearchAdaptor Proteins, Signal TransducingAutism Spectrum DisorderBasic Helix-Loop-Helix Transcription FactorsBrainBrain MappingCase-Control StudiesChildChild, PreschoolChromosomes, Human, XDisease ProgressionDNA Copy Number VariationsExome SequencingFemaleGene ExpressionHumansIntellectual DisabilityMagnetic Resonance ImagingMaleMaternal InheritanceNuclear ProteinsPhenotypePolymorphism, GeneticSeverity of Illness IndexSiblingsTranscription FactorsTranscriptome
2016
Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism
Gordon I, Jack A, Pretzsch CM, Vander Wyk B, Leckman JF, Feldman R, Pelphrey KA. Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism. Scientific Reports 2016, 6: 35054. PMID: 27845765, PMCID: PMC5109935, DOI: 10.1038/srep35054.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderIntranasal oxytocinSocial motivationSocial perceptionSocial-emotional informationFunctional magnetic resonance imagingPlacebo-controlled crossover designBiological motionSocial stimuliAngry voicesSocial deficitsSpectrum disorderOT administrationMesolimbic reward pathwayBehavioral treatmentBrain rewardReduced connectivityBrain regionsReward pathwayCortical sitesRewardPerceptionMotivationOxytocinBrain sitesNeural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward
Sukhodolsky DG, Wyk B, Eilbott JA, McCauley SA, Ibrahim K, Crowley MJ, Pelphrey KA. Neural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 38-48. PMID: 26784537, PMCID: PMC4779273, DOI: 10.1089/cap.2015.0164.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionChildChild Behavior DisordersCognitive Behavioral TherapyElectroencephalographyFemaleHumansMagnetic Resonance ImagingMaleMental HealthResearch DesignConceptsCognitive behavioral therapyReactive aggressionResearch Domain Criteria (RDoC) constructsSessions of CBTEmotional face perceptionEmotion regulation circuitryBrain-behavior associationsAggressive behaviorFunctional magnetic resonanceFace perceptionNon-RewardTraditional diagnostic categoriesNoGo taskFMRI scanningRDoC constructsElectrophysiological correlatesNeural mechanismsCriterion constructsFunctional neuroimagingBehavioral levelStrategic research prioritiesAge 8AggressionAdolescentsSupportive psychotherapy
2015
Normalization of brain morphology after surgery in sagittal craniosynostosis.
Brooks ED, Yang J, Beckett JS, Lacadie C, Scheinost D, Persing S, Zellner EG, Oosting D, Keifer C, Friedman HE, Wyk BV, Jou RJ, Sun H, Gary C, Duncan CC, Constable RT, Pelphrey KA, Persing JA. Normalization of brain morphology after surgery in sagittal craniosynostosis. Journal Of Neurosurgery Pediatrics 2015, 17: 460-8. PMID: 26684766, PMCID: PMC7182140, DOI: 10.3171/2015.7.peds15221.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainChildCraniosynostosesFemaleFollow-Up StudiesHumansInfantMagnetic Resonance ImagingMaleOutcome Assessment, Health CareConceptsBrain growthNonsyndromic craniosynostosisBrain morphological differencesWhole-brain techniqueYears of ageSignificant learning disabilitiesIQ-matched control subjectsUntreated infantsMean ageAdolescent patientsControl subjectsWhole-vault cranioplastyBrain dysmorphologySurgical reconstructionBrain areasTemporooccipital regionsSmall cohortSurgeryCognitive functionBrain morphologyBrain normalizationSagittal craniosynostosisLiberal thresholdSagittal nonsyndromic craniosynostosisFrontoparietal regionsUnlike adults, children and adolescents show predominantly increased neural activation to social exclusion by members of the opposite gender
Bolling DZ, Pelphrey KA, Vander Wyk B. Unlike adults, children and adolescents show predominantly increased neural activation to social exclusion by members of the opposite gender. Social Neuroscience 2015, 11: 475-486. PMID: 26592311, PMCID: PMC4976300, DOI: 10.1080/17470919.2015.1117019.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingNeural correlatesGroup membershipOnline ball-tossing gameSocial exclusionAnterior cingulate responsesBall-tossing gameSocial anxiety disorderOpposite genderSocio-emotional developmentDifferential neural correlatesAnterior cingulate cortexPrevious adult studiesPeer rejectionCingulate responseBrain responsesPeer relationsNeural activationAnxiety disordersCingulate cortexMain effectCurrent studyAdolescenceIncreased activationAdolescentsTrait-level temporal lobe hypoactivation to social exclusion in unaffected siblings of children and adolescents with autism spectrum disorders
Bolling DZ, Pelphrey KA, Wyk B. Trait-level temporal lobe hypoactivation to social exclusion in unaffected siblings of children and adolescents with autism spectrum disorders. Developmental Cognitive Neuroscience 2015, 13: 75-83. PMID: 26011751, PMCID: PMC4470300, DOI: 10.1016/j.dcn.2015.04.007.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild Development Disorders, PervasiveFemaleHumansMagnetic Resonance ImagingMalePsychological DistanceSiblingsTemporal LobeConceptsAutism spectrum disorderSpectrum disorderPosterior superior temporal sulcusUnaffected siblingsAtypical neural processingSocial exclusionFunctional magnetic resonance imagingSuperior temporal sulcusAbnormal neural responsesAnterior temporoparietal junctionAnterior cingulate cortexEmotion processingTemporoparietal junctionNegative affectTemporal sulcusNeural processingBrain responsesNeural endophenotypesNeural responsesNeural activationCingulate cortexNeural circuitrySocial experienceASD probandsPowerful feelings
2014
Altered brain connectivity in sagittal craniosynostosis.
Beckett JS, Brooks ED, Lacadie C, Wyk B, Jou RJ, Steinbacher DM, Constable RT, Pelphrey KA, Persing JA. Altered brain connectivity in sagittal craniosynostosis. Journal Of Neurosurgery Pediatrics 2014, 13: 690-8. PMID: 24745341, DOI: 10.3171/2014.3.peds13516.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingCerebral CortexChildCraniosynostosesDiffusion Tensor ImagingFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMiddle AgedParietal LobeTemporal LobeConceptsDiffusion tensor imagingPosterior cingulate cortexCingulate cortexSagittal nonsyndromic craniosynostosisPrefrontal cortexRight posterior cingulate cortexBrodmann area 8Functional connectivity differencesRight middle frontal gyrusWhite matter alterationsAnterior cingulate cortexBrodmann area 7Left ventromedial prefrontal cortexAltered brain connectivityResting-state functional connectivity MRI dataMiddle frontal gyrusRight supramarginal gyrusDefault mode networkIntrinsic connectivity analysesSignificant group differencesAdolescent patientsAltered connectivityNeurocognitive morbidityHigh prevalenceRight parahippocampus
2013
Oxytocin enhances brain function in children with autism
Gordon I, Vander Wyk B, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, Zagoory-Sharon O, Leckman JF, Feldman R, Pelphrey KA. Oxytocin enhances brain function in children with autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 20953-20958. PMID: 24297883, PMCID: PMC3876263, DOI: 10.1073/pnas.1312857110.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntranasalAdolescentAmygdalaChildChild Development Disorders, PervasiveFemaleFrontal LobeHumansJudgmentMagnetic Resonance ImagingMaleOxytocinSalivaSocial AdjustmentConceptsAutism spectrum disorderSuperior temporal sulcusTemporal sulcusOrbitofrontal cortexLeft superior temporal sulcusMiddle frontal gyrusMedial prefrontal cortexRight orbitofrontal cortexSocial attunementSocial judgmentsMeaningful stimuliFrontal gyrusSpectrum disorderBrain activityPrefrontal cortexRight amygdalaSocial functioningFunctional MRIPremotor cortexHedonic evaluationBrain functionJudgmentsCortexChildrenOxytocinSocial, reward, and attention brain networks are involved when online bids for joint attention are met with congruent versus incongruent responses
Gordon I, Eilbott JA, Feldman R, Pelphrey KA, Vander Wyk B. Social, reward, and attention brain networks are involved when online bids for joint attention are met with congruent versus incongruent responses. Social Neuroscience 2013, 8: 544-554. PMID: 24044427, DOI: 10.1080/17470919.2013.832374.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionBrainBrain MappingEye MovementsFemaleHumansImage Processing, Computer-AssistedInterpersonal RelationsMagnetic Resonance ImagingMaleNeural PathwaysRewardYoung AdultConceptsJoint attentionTemporoparietal junctionIncongruent responsesFMRI paradigmFunctional magnetic resonance imaging (fMRI) researchDorsal anterior cingulate cortexNaturalistic fMRI paradigmsHuman social functioningImpact of congruencySocial responsesRight temporoparietal junctionEye gaze patternsRight fusiform gyrusPosterior parietal cortexMagnetic resonance imaging researchAnterior cingulate cortexSocial neuroscienceIncongruent trialsAttention circuitsFusiform gyrusCongruent responsesNeural activationBrain networksRight amygdalaSocial functioningEquivalent neural responses in children and adolescents with and without autism during judgments of affect
Wyk B, Hoffman F, Pelphrey KA. Equivalent neural responses in children and adolescents with and without autism during judgments of affect. Developmental Cognitive Neuroscience 2013, 8: 121-130. PMID: 24016745, PMCID: PMC3931746, DOI: 10.1016/j.dcn.2013.08.001.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCognitive loadNeural activationGreater cognitive loadFunction of taskFunctional connectivity analysisLonger stimulus durationsEmotion processingFMRI taskCondition contrastsNeural responsesSpectrum disorderStimulus durationBehavior measuresConnectivity analysisGroup differencesPrior researchPrevious researchEmotionsTaskChildrenValence levelsIQAutismIndividualsBrain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings
Zebardast N, Crowley MJ, Bloch MH, Mayes LC, Wyk BV, Leckman JF, Pelphrey KA, Swain JE. Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: Initial findings. Psychiatry Research 2013, 214: 33-41. PMID: 23916249, PMCID: PMC3932431, DOI: 10.1016/j.pscychresns.2013.05.009.Peer-Reviewed Original ResearchConceptsTourette syndromeFunctional magnetic resonance imagingHealthy subjectsTic severityWhole-brain functional magnetic resonance imagingYale Global Tic Severity ScaleTactile startle responseCase-control study designTic Severity ScaleCortical-striatal circuitsBrain activityMagnetic resonance imagingMultiple brain regionsLeft middle frontal gyrusMiddle frontal gyrusDegree of PPIPulse-alone stimuliBlock-design fMRI paradigmTic symptomsNeuropathological dataHealthy controlsPrepulse inhibitionDevelopmental neuropsychiatric disordersSensorimotor gatingLeft caudate
2012
Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case Studies
Voos AC, Pelphrey KA, Tirrell J, Bolling DZ, Wyk B, Kaiser MD, McPartland JC, Volkmar FR, Ventola P. Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case Studies. Journal Of Autism And Developmental Disorders 2012, 43: 1-10. PMID: 23104615, PMCID: PMC4999079, DOI: 10.1007/s10803-012-1683-9.Peer-Reviewed Original ResearchMeSH KeywordsBehavior TherapyBrainChild BehaviorChild Development Disorders, PervasiveChild, PreschoolCommunicationEye MovementsFemaleHumansMagnetic Resonance ImagingMaleMotivationSocial BehaviorConceptsPivotal Response TreatmentAutism spectrum disorderSocial stimuliResponse treatmentFunctional magnetic resonance imagingYoung childrenNeural correlatesSocial motivationSocial skillsSocial perceptionNeural mechanismsNeural responsesBehavioral measuresSpectrum disorderSocial communicationBehavioral treatmentEye trackingNeural systemsAdaptive behaviorBrain regionsBaseline measuresStriking gainsStimuliChildrenPositive effectAction representation in the superior temporal sulcus in children and adults: An fMRI study
Vander Wyk B, Voos A, Pelphrey KA. Action representation in the superior temporal sulcus in children and adults: An fMRI study. Developmental Cognitive Neuroscience 2012, 2: 409-416. PMID: 22727762, PMCID: PMC3431200, DOI: 10.1016/j.dcn.2012.04.004.Peer-Reviewed Original ResearchConceptsSuperior temporal sulcusFunctional magnetic resonance imaging paradigmCongruent trialsTemporal sulcusPosterior superior temporal sulcusIncongruent actionsBiological motionSTS regionFMRI studyAction representationNegative regardImaging paradigmOrder informationHigher-order informationDevelopmental changesOlder childrenChildrenSulcusAdultsTrialsCongruencyRepresentationCongruentPerceptionObjects
2011
Differential brain responses to social exclusion by one's own versus opposite-gender peers
Bolling DZ, Pelphrey KA, Vander Wyk B. Differential brain responses to social exclusion by one's own versus opposite-gender peers. Social Neuroscience 2011, 7: 331-346. PMID: 21981758, PMCID: PMC4520218, DOI: 10.1080/17470919.2011.623181.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain MappingFemaleGender IdentityHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMalePeer GroupPsychological DistanceRejection, PsychologyYoung AdultConceptsCortex activationVentrolateral prefrontal cortex activationImplicit gender attitudesAnterior cingulate cortex activationBall-tossing gameOpposite-gender peersDifferential brain responsesVentrolateral prefrontal cortexSelf-reported distressPrefrontal cortex activationSame-gender peersFunctional magnetic resonanceSocial exclusionSocial cognitionIndividual differencesPsychological threatBrain responsesNeural responsesPeer relationsPrefrontal cortexEmotional benefitsOwn genderOpposite genderGender attitudesCurrent studyBrain Mechanisms for Processing Direct and Averted Gaze in Individuals with Autism
Pitskel NB, Bolling DZ, Hudac CM, Lantz SD, Minshew NJ, Vander Wyk BC, Pelphrey KA. Brain Mechanisms for Processing Direct and Averted Gaze in Individuals with Autism. Journal Of Autism And Developmental Disorders 2011, 41: 1686-1693. PMID: 21484518, PMCID: PMC3337548, DOI: 10.1007/s10803-011-1197-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttentionAutistic DisorderBrainCuesEye MovementsFemaleHumansInterpersonal RelationsMagnetic Resonance ImagingMalePhotic StimulationSocial PerceptionConceptsAverted gazeBrain mechanismsCritical social cueRight temporoparietal junctionLateral occipital cortexDorsolateral prefrontal cortexRight anterior insulaSocial processingTemporoparietal junctionSocial cuesComparison participantsAnterior insulaFMRI studySocial deficitsSocial scenariosGaze directionPrefrontal cortexCondition interactionAutismSocial encountersDifferential processingInitial evidenceOccipital cortexGazeSignificant groupResearch Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder
Pelphrey KA, Shultz S, Hudac CM, Wyk B. Research Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder. Journal Of Child Psychology And Psychiatry 2011, 52: 631-644. PMID: 21244421, PMCID: PMC3096715, DOI: 10.1111/j.1469-7610.2010.02349.x.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaBrainBrain MappingChildChild Development Disorders, PervasiveEmotionsEndophenotypesFacial ExpressionFemaleGenetic Predisposition to DiseaseHumansIntentionMagnetic Resonance ImagingMaleNerve NetPattern Recognition, VisualPersonal Construct TheorySocializationTemporal LobeTheory of MindConceptsAutism spectrum disorderSocial information processingSuperior temporal sulcusSpectrum disorderPosterior superior temporal sulcusInformation processingSocial engagementSpecialized neural systemsModel of ASDFunctional neuroimaging researchSocial brainTemporal sulcusBrain mechanismsNeuroimaging researchSocial reciprocityRepetitive behaviorsNeural circuitryNeural systemsBrain endophenotypesDevelopmental studiesDevastating familySocial worldNeurodevelopmental disordersNeural structuresNeuroanatomical structures
2010
Neural signatures of autism
Kaiser MD, Hudac CM, Shultz S, Lee SM, Cheung C, Berken AM, Deen B, Pitskel NB, Sugrue DR, Voos AC, Saulnier CA, Ventola P, Wolf JM, Klin A, Vander Wyk B, Pelphrey KA. Neural signatures of autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 21223-21228. PMID: 21078973, PMCID: PMC3000300, DOI: 10.1073/pnas.1010412107.Peer-Reviewed Original ResearchMeSH KeywordsAutistic DisorderChildChild Development Disorders, PervasiveHumansMagnetic Resonance ImagingMovementNeuronsSiblingsConceptsAutism spectrum disorderNeural signaturesBiological motionBrain responsesUnaffected siblingsDistinct brain responsesFunctional magnetic resonanceAreas of dysfunctionNature of disruptionTD childrenSpectrum disorderDisorder heterogeneityNeural systemsBrain circuitryBehavioral profileCompensatory activitySystem-level mechanismsTrait activityAutismChildrenIncreased genetic riskGenetic riskState activityNeuroendophenotypesDisordersCortical integration of audio–visual speech and non-speech stimuli
Wyk B, Ramsay GJ, Hudac CM, Jones W, Lin D, Klin A, Lee SM, Pelphrey KA. Cortical integration of audio–visual speech and non-speech stimuli. Brain And Cognition 2010, 74: 97-106. PMID: 20709442, PMCID: PMC3869029, DOI: 10.1016/j.bandc.2010.07.002.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdultAnalysis of VarianceAuditory PerceptionBrain MappingCerebral CortexHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingSpeechVisual PerceptionConceptsLateral occipital cortexUni-modal stimuliNon-speech stimuliAudio-visual speechVisual stimuliOccipital cortexRight inferior frontal gyrusAudio-visual pairingsSimilar auditory stimuliMulti-modal stimuliAudio-visual processingSuperior temporal sulcusInferior frontal gyrusMiddle temporal regionsMiddle temporal gyrusDifferent cortical networksNeural basisTemporal sulcusAuditory stimuliFusiform gyrusFrontal gyrusTemporal gyrusCortical networksCortical integrationTemporal regionsBrain mechanisms for representing what another person sees
Heyda RD, Green SR, Vander Wyk B, Morris JP, Pelphrey KA. Brain mechanisms for representing what another person sees. NeuroImage 2010, 50: 693-700. PMID: 20056152, PMCID: PMC2824003, DOI: 10.1016/j.neuroimage.2009.12.101.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleSocial PerceptionVisual PerceptionYoung AdultConceptsExtrastriate body areaParahippocampal place areaFunctional magnetic resonance imagingSocial cognitionVisual attentionDual-role hypothesisAttribution hypothesisPerson's visual attentionWhole-brain analysisSocial brainStimulus categoriesBrain mechanismsPlace areaVisible stimuliVisual regionsSame stimuliBrain regionsInterest analysisCognitionStimuliParticipants' viewsSpecific categoriesMagnetic resonance imagingExtrastriateHypothesis
2009
Action Understanding in the Superior Temporal Sulcus Region
Vander Wyk BC, Hudac CM, Carter EJ, Sobel DM, Pelphrey KA. Action Understanding in the Superior Temporal Sulcus Region. Psychological Science 2009, 20: 771-777. PMID: 19422619, PMCID: PMC2849148, DOI: 10.1111/j.1467-9280.2009.02359.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionBrain MappingChoice BehaviorColor PerceptionConcept FormationDominance, CerebralEmotionsFemaleHumansImage Processing, Computer-AssistedIntentionMagnetic Resonance ImagingMaleMotion PerceptionOxygenPattern Recognition, VisualPersonal Construct TheoryPsychomotor PerformanceSocial PerceptionTemporal LobeYoung AdultConceptsSuperior temporal sulcus regionEmotional expressionSTS regionPosterior superior temporal sulcus regionSulcus regionFunctional magnetic resonancePosterior STSAction understandingBiological motionEmotional contextNegative emotionsNegative regardPositive regardPerson's motionSocial actCongruentParticipantsIntentionEmotionsObjectsCongruencyPerceptionActionActressMagnetic resonance