2017
Neurogenetic analysis of childhood disintegrative disorder
Gupta AR, Westphal A, Yang DYJ, Sullivan CAW, Eilbott J, Zaidi S, Voos A, Vander Wyk BC, Ventola P, Waqar Z, Fernandez TV, Ercan-Sencicek AG, Walker MF, Choi M, Schneider A, Hedderly T, Baird G, Friedman H, Cordeaux C, Ristow A, Shic F, Volkmar FR, Pelphrey KA. Neurogenetic analysis of childhood disintegrative disorder. Molecular Autism 2017, 8: 19. PMID: 28392909, PMCID: PMC5379515, DOI: 10.1186/s13229-017-0133-0.Peer-Reviewed Original ResearchAdaptor Proteins, Signal TransducingAutism Spectrum DisorderBasic Helix-Loop-Helix Transcription FactorsBrainBrain MappingCase-Control StudiesChildChild, PreschoolChromosomes, Human, XDisease ProgressionDNA Copy Number VariationsExome SequencingFemaleGene ExpressionHumansIntellectual DisabilityMagnetic Resonance ImagingMaleMaternal InheritanceNuclear ProteinsPhenotypePolymorphism, GeneticSeverity of Illness IndexSiblingsTranscription FactorsTranscriptome
2016
Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism
Gordon I, Jack A, Pretzsch CM, Vander Wyk B, Leckman JF, Feldman R, Pelphrey KA. Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism. Scientific Reports 2016, 6: 35054. PMID: 27845765, PMCID: PMC5109935, DOI: 10.1038/srep35054.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderIntranasal oxytocinSocial motivationSocial perceptionSocial-emotional informationFunctional magnetic resonance imagingPlacebo-controlled crossover designBiological motionSocial stimuliAngry voicesSocial deficitsSpectrum disorderOT administrationMesolimbic reward pathwayBehavioral treatmentBrain rewardReduced connectivityBrain regionsReward pathwayCortical sitesRewardPerceptionMotivationOxytocinBrain sitesNeural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward
Sukhodolsky DG, Wyk B, Eilbott JA, McCauley SA, Ibrahim K, Crowley MJ, Pelphrey KA. Neural Mechanisms of Cognitive-Behavioral Therapy for Aggression in Children and Adolescents: Design of a Randomized Controlled Trial Within the National Institute for Mental Health Research Domain Criteria Construct of Frustrative Non-Reward. Journal Of Child And Adolescent Psychopharmacology 2016, 26: 38-48. PMID: 26784537, PMCID: PMC4779273, DOI: 10.1089/cap.2015.0164.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyReactive aggressionResearch Domain Criteria (RDoC) constructsSessions of CBTEmotional face perceptionEmotion regulation circuitryBrain-behavior associationsAggressive behaviorFunctional magnetic resonanceFace perceptionNon-RewardTraditional diagnostic categoriesNoGo taskFMRI scanningRDoC constructsElectrophysiological correlatesNeural mechanismsCriterion constructsFunctional neuroimagingBehavioral levelStrategic research prioritiesAge 8AggressionAdolescentsSupportive psychotherapy
2015
Normalization of brain morphology after surgery in sagittal craniosynostosis.
Brooks ED, Yang J, Beckett JS, Lacadie C, Scheinost D, Persing S, Zellner EG, Oosting D, Keifer C, Friedman HE, Wyk BV, Jou RJ, Sun H, Gary C, Duncan CC, Constable RT, Pelphrey KA, Persing JA. Normalization of brain morphology after surgery in sagittal craniosynostosis. Journal Of Neurosurgery Pediatrics 2015, 17: 460-8. PMID: 26684766, PMCID: PMC7182140, DOI: 10.3171/2015.7.peds15221.Peer-Reviewed Original ResearchConceptsBrain growthNonsyndromic craniosynostosisBrain morphological differencesWhole-brain techniqueYears of ageSignificant learning disabilitiesIQ-matched control subjectsUntreated infantsMean ageAdolescent patientsControl subjectsWhole-vault cranioplastyBrain dysmorphologySurgical reconstructionBrain areasTemporooccipital regionsSmall cohortSurgeryCognitive functionBrain morphologyBrain normalizationSagittal craniosynostosisLiberal thresholdSagittal nonsyndromic craniosynostosisFrontoparietal regionsUnlike adults, children and adolescents show predominantly increased neural activation to social exclusion by members of the opposite gender
Bolling DZ, Pelphrey KA, Vander Wyk B. Unlike adults, children and adolescents show predominantly increased neural activation to social exclusion by members of the opposite gender. Social Neuroscience 2015, 11: 475-486. PMID: 26592311, PMCID: PMC4976300, DOI: 10.1080/17470919.2015.1117019.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingNeural correlatesGroup membershipOnline ball-tossing gameSocial exclusionAnterior cingulate responsesBall-tossing gameSocial anxiety disorderOpposite genderSocio-emotional developmentDifferential neural correlatesAnterior cingulate cortexPrevious adult studiesPeer rejectionCingulate responseBrain responsesPeer relationsNeural activationAnxiety disordersCingulate cortexMain effectCurrent studyAdolescenceIncreased activationAdolescentsTrait-level temporal lobe hypoactivation to social exclusion in unaffected siblings of children and adolescents with autism spectrum disorders
Bolling DZ, Pelphrey KA, Wyk B. Trait-level temporal lobe hypoactivation to social exclusion in unaffected siblings of children and adolescents with autism spectrum disorders. Developmental Cognitive Neuroscience 2015, 13: 75-83. PMID: 26011751, PMCID: PMC4470300, DOI: 10.1016/j.dcn.2015.04.007.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderPosterior superior temporal sulcusUnaffected siblingsAtypical neural processingSocial exclusionFunctional magnetic resonance imagingSuperior temporal sulcusAbnormal neural responsesAnterior temporoparietal junctionAnterior cingulate cortexEmotion processingTemporoparietal junctionNegative affectTemporal sulcusNeural processingBrain responsesNeural endophenotypesNeural responsesNeural activationCingulate cortexNeural circuitrySocial experienceASD probandsPowerful feelings
2014
Altered brain connectivity in sagittal craniosynostosis.
Beckett JS, Brooks ED, Lacadie C, Wyk B, Jou RJ, Steinbacher DM, Constable RT, Pelphrey KA, Persing JA. Altered brain connectivity in sagittal craniosynostosis. Journal Of Neurosurgery Pediatrics 2014, 13: 690-8. PMID: 24745341, DOI: 10.3171/2014.3.peds13516.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingPosterior cingulate cortexCingulate cortexSagittal nonsyndromic craniosynostosisPrefrontal cortexRight posterior cingulate cortexBrodmann area 8Functional connectivity differencesRight middle frontal gyrusWhite matter alterationsAnterior cingulate cortexBrodmann area 7Left ventromedial prefrontal cortexAltered brain connectivityResting-state functional connectivity MRI dataMiddle frontal gyrusRight supramarginal gyrusDefault mode networkIntrinsic connectivity analysesSignificant group differencesAdolescent patientsAltered connectivityNeurocognitive morbidityHigh prevalenceRight parahippocampus
2013
Oxytocin enhances brain function in children with autism
Gordon I, Vander Wyk B, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, Zagoory-Sharon O, Leckman JF, Feldman R, Pelphrey KA. Oxytocin enhances brain function in children with autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 20953-20958. PMID: 24297883, PMCID: PMC3876263, DOI: 10.1073/pnas.1312857110.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSuperior temporal sulcusTemporal sulcusOrbitofrontal cortexLeft superior temporal sulcusMiddle frontal gyrusMedial prefrontal cortexRight orbitofrontal cortexSocial attunementSocial judgmentsMeaningful stimuliFrontal gyrusSpectrum disorderBrain activityPrefrontal cortexRight amygdalaSocial functioningFunctional MRIPremotor cortexHedonic evaluationBrain functionJudgmentsCortexChildrenOxytocinEquivalent neural responses in children and adolescents with and without autism during judgments of affect
Wyk B, Hoffman F, Pelphrey KA. Equivalent neural responses in children and adolescents with and without autism during judgments of affect. Developmental Cognitive Neuroscience 2013, 8: 121-130. PMID: 24016745, PMCID: PMC3931746, DOI: 10.1016/j.dcn.2013.08.001.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCognitive loadNeural activationGreater cognitive loadFunction of taskFunctional connectivity analysisLonger stimulus durationsEmotion processingFMRI taskCondition contrastsNeural responsesSpectrum disorderStimulus durationBehavior measuresConnectivity analysisGroup differencesPrior researchPrevious researchEmotionsTaskChildrenValence levelsIQAutismIndividuals
2012
Action representation in the superior temporal sulcus in children and adults: An fMRI study
Vander Wyk B, Voos A, Pelphrey KA. Action representation in the superior temporal sulcus in children and adults: An fMRI study. Developmental Cognitive Neuroscience 2012, 2: 409-416. PMID: 22727762, PMCID: PMC3431200, DOI: 10.1016/j.dcn.2012.04.004.Peer-Reviewed Original ResearchConceptsSuperior temporal sulcusFunctional magnetic resonance imaging paradigmCongruent trialsTemporal sulcusPosterior superior temporal sulcusIncongruent actionsBiological motionSTS regionFMRI studyAction representationNegative regardImaging paradigmOrder informationHigher-order informationDevelopmental changesOlder childrenChildrenSulcusAdultsTrialsCongruencyRepresentationCongruentPerceptionObjects
2011
Enhanced neural responses to rule violation in children with autism: A comparison to social exclusion
Bolling DZ, Pitskel NB, Deen B, Crowley MJ, McPartland JC, Kaiser MD, Vander Wyk BC, Wu J, Mayes LC, Pelphrey KA. Enhanced neural responses to rule violation in children with autism: A comparison to social exclusion. Developmental Cognitive Neuroscience 2011, 1: 280-294. PMID: 21743819, PMCID: PMC3129780, DOI: 10.1016/j.dcn.2011.02.002.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderFunctional magnetic resonance imagingRight insulaVentral anterior cingulate cortexSocial exclusionAtypical neural networksRule violationsBall-tossing gameDorsal prefrontal cortexRepetitive behavior patternsAnterior cingulate cortexASD groupNeural correlatesBrain responsesSocial impairmentNeural responsesCharacteristic deficitsSpectrum disorderNeurobiological differencesPrefrontal cortexCingulate cortexFunctional connectivityComparable gamesInsulaGroup differencesResearch Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder
Pelphrey KA, Shultz S, Hudac CM, Wyk B. Research Review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder. Journal Of Child Psychology And Psychiatry 2011, 52: 631-644. PMID: 21244421, PMCID: PMC3096715, DOI: 10.1111/j.1469-7610.2010.02349.x.Peer-Reviewed Original ResearchMeSH KeywordsAmygdalaBrainBrain MappingChildChild Development Disorders, PervasiveEmotionsEndophenotypesFacial ExpressionFemaleGenetic Predisposition to DiseaseHumansIntentionMagnetic Resonance ImagingMaleNerve NetPattern Recognition, VisualPersonal Construct TheorySocializationTemporal LobeTheory of MindConceptsAutism spectrum disorderSocial information processingSuperior temporal sulcusSpectrum disorderPosterior superior temporal sulcusInformation processingSocial engagementSpecialized neural systemsModel of ASDFunctional neuroimaging researchSocial brainTemporal sulcusBrain mechanismsNeuroimaging researchSocial reciprocityRepetitive behaviorsNeural circuitryNeural systemsBrain endophenotypesDevelopmental studiesDevastating familySocial worldNeurodevelopmental disordersNeural structuresNeuroanatomical structures
2010
Neural signatures of autism
Kaiser MD, Hudac CM, Shultz S, Lee SM, Cheung C, Berken AM, Deen B, Pitskel NB, Sugrue DR, Voos AC, Saulnier CA, Ventola P, Wolf JM, Klin A, Vander Wyk B, Pelphrey KA. Neural signatures of autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 21223-21228. PMID: 21078973, PMCID: PMC3000300, DOI: 10.1073/pnas.1010412107.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNeural signaturesBiological motionBrain responsesUnaffected siblingsDistinct brain responsesFunctional magnetic resonanceAreas of dysfunctionNature of disruptionTD childrenSpectrum disorderDisorder heterogeneityNeural systemsBrain circuitryBehavioral profileCompensatory activitySystem-level mechanismsTrait activityAutismChildrenIncreased genetic riskGenetic riskState activityNeuroendophenotypesDisorders