2002
Modular Interaction Strengths in Regulatory Networks; An Example
Bruggeman F, Kholodenko B. Modular Interaction Strengths in Regulatory Networks; An Example. Molecular Biology Reports 2002, 29: 57-61. PMID: 12241075, DOI: 10.1023/a:1020354302260.Peer-Reviewed Original Research
1997
Quantification of information transfer via cellular signal transduction pathways
Kholodenko B, Hoek J, Westerhoff H, Brown G. Quantification of information transfer via cellular signal transduction pathways. FEBS Letters 1997, 414: 430-434. PMID: 9315734, DOI: 10.1016/s0014-5793(97)01018-1.Peer-Reviewed Original Research
1996
Paradoxical control properties of enzymes within pathways: can activation cause an enzyme to have increased control?
KHOLODENKO B, BROWN G. Paradoxical control properties of enzymes within pathways: can activation cause an enzyme to have increased control? Biochemical Journal 1996, 314: 753-760. PMID: 8615766, PMCID: PMC1217121, DOI: 10.1042/bj3140753.Peer-Reviewed Original ResearchEffect of channelling on the concentration of bulk-phase intermediates as cytosolic proteins become more concentrated
KHOLODENKO B, WESTERHOFF H, CASCANTE C. Effect of channelling on the concentration of bulk-phase intermediates as cytosolic proteins become more concentrated. Biochemical Journal 1996, 313: 921-926. PMID: 8611176, PMCID: PMC1216999, DOI: 10.1042/bj3130921.Peer-Reviewed Original Research
1995
Elusive control
Westerhoff H, Kholodenko B, Cascante M, Van Dam K. Elusive control. Journal Of Bioenergetics And Biomembranes 1995, 27: 491-497. PMID: 8718454, DOI: 10.1007/bf02110189.Peer-Reviewed Original ResearchEnergy, control and DNA structure in the living cell
Wijker J, Jensen P, Snoep J, Gomes A, Guiral M, Jongsma A, de Waal A, Hoving S, van Dooren S, van der Weijden C, van Workum M, van Heeswijk W, Molenaar O, Wielinga P, Richard P, Diderich J, Bakker B, Teusink B, Hemker M, Rohwer J, van der Gugten A, Kholodenko B, Westerhoff H. Energy, control and DNA structure in the living cell. Biophysical Chemistry 1995, 55: 153-165. PMID: 7632875, DOI: 10.1016/0301-4622(94)00148-d.Peer-Reviewed Original ResearchConceptsHigh ATP/ADP ratiosATP/ADP ratioCell physiologyADP ratioCertain cell typesCellular functionsIntracellular ATP levelsTransduction pathwaysDNA structureLiving cellsCell typesIon gradientsHomeostatic control mechanismsATP levelsCell functionElaborate controlPhysiologyCellsControl mechanismsMaintenanceCoenzyme cycles and metabolic control analysis: the determination of the elasticity coefficients from the generalised connectivity theorem.
Kholodenko B, Sauro H, Westerhoff H, Cascante M. Coenzyme cycles and metabolic control analysis: the determination of the elasticity coefficients from the generalised connectivity theorem. IUBMB Life 1995, 35: 615-25. PMID: 7773196.Peer-Reviewed Original ResearchControl theory of metabolic channelling
Kholodenko B, Cascante M, Westerhoff H. Control theory of metabolic channelling. Molecular And Cellular Biochemistry 1995, 143: 151-168. PMID: 7596350, DOI: 10.1007/bf01816949.Peer-Reviewed Original ResearchConceptsControl theory
1993
Dramatic changes in control properties that accompany channelling and metabolite sequestration
Kholodenko B, Cascante M, Westerhoff H. Dramatic changes in control properties that accompany channelling and metabolite sequestration. FEBS Letters 1993, 336: 381-384. PMID: 8282097, DOI: 10.1016/0014-5793(93)80841-h.Peer-Reviewed Original ResearchThe sum of the control coefficients of all enzymes on the flux through a group‐transfer pathway can be as high as two
van DAM K, van der VLAG J, KHOLODENKO B, WESTERHOFF H. The sum of the control coefficients of all enzymes on the flux through a group‐transfer pathway can be as high as two. The FEBS Journal 1993, 212: 791-799. PMID: 8462550, DOI: 10.1111/j.1432-1033.1993.tb17720.x.Peer-Reviewed Original ResearchConceptsGroup-transfer pathwaysReaction activityDissociation rate constantsElectron transfer chainAcceptor couplesEnzyme-enzyme interactionsEnzyme concentrationRate constantsEnzyme-enzyme complexEnzyme interactionsComplexesControl of enzymesEnzyme complexEnzymeConcentrationBacterial phosphoenolpyruvateMain pathwayInteractionConstantsChainControl analysisSimple metabolic pathwaysSugar phosphotransferase system
1989
Theory of metabolism regulation: a complete system of equations for regulation coefficients.
Kholodenko B, Erlikh L. Theory of metabolism regulation: a complete system of equations for regulation coefficients. Биофизика 1989, 34: 802-7. PMID: 2611277.Peer-Reviewed Original Research
1988
How do external parameters control fluxes and concentrations of metabolites? An additional relationship in the theory of metabolic control
Kholodenko B. How do external parameters control fluxes and concentrations of metabolites? An additional relationship in the theory of metabolic control. FEBS Letters 1988, 232: 383-386. PMID: 3378629, DOI: 10.1016/0014-5793(88)80775-0.Peer-Reviewed Original Research
1985
Role of the 2,3-diphosphoglycerate shunt in regulating energy metabolism in human erythrocytes.
Kholodenko B, Stepanchikova A, Erlikh L, Ataullakhanov F, Zhabotinskiĭ A. Role of the 2,3-diphosphoglycerate shunt in regulating energy metabolism in human erythrocytes. Bulletin Of The Russian Academy Of Sciences. Biological Series 1985, 196-205. PMID: 3157714.Peer-Reviewed Original Research
1984
Control of mitochondrial oxidative phosphorylation
Kholodenko B. Control of mitochondrial oxidative phosphorylation. Journal Of Theoretical Biology 1984, 107: 179-188. PMID: 6717037, DOI: 10.1016/s0022-5193(84)80020-x.Peer-Reviewed Original Research
1982
Dynamic stability of steady states and static stabilization in unbranched metabolic pathways
Dibrov B, Zhabotinsky A, Kholodenko B. Dynamic stability of steady states and static stabilization in unbranched metabolic pathways. Journal Of Mathematical Biology 1982, 15: 51-63. PMID: 7142835, DOI: 10.1007/bf00275788.Peer-Reviewed Original ResearchOptical tactics of antibacterial therapy for the trigger model of the infection process.
Kholodenko B, Geviksman K, Kholodov L. Optical tactics of antibacterial therapy for the trigger model of the infection process. Биофизика 1982, 27: 900-5. PMID: 7138944.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacterial InfectionsDrug Administration ScheduleHumansMathematicsModels, Biological
1981
The Regulation of Glycolysis in Human Erythrocytes
ATAULLAKHANOV F, VITVITSKY V, ZHABOTINSKY A, PICHUGIN A, PLATONOVA O, KHOLODENKO B, EHRLICH L. The Regulation of Glycolysis in Human Erythrocytes. The FEBS Journal 1981, 115: 359-365. PMID: 7238510, DOI: 10.1111/j.1432-1033.1981.tb05246.x.Peer-Reviewed Original ResearchRegulation of erythrocyte energy metabolism. Dependence of glycolysis characteristics on donor individual parameters.
Kholodenko B, Dibrov B, Zhabotinskiĭ A. Regulation of erythrocyte energy metabolism. Dependence of glycolysis characteristics on donor individual parameters. Биофизика 1981, 26: 501-6. PMID: 6455164.Peer-Reviewed Original ResearchDynamic stability of a metabolic pathway with single-loop feedback.
Dibrov B, Zhabotinskiĭ A, Kholodenko B. Dynamic stability of a metabolic pathway with single-loop feedback. Биофизика 1981, 26: 590-5. PMID: 7284447.Peer-Reviewed Original ResearchDynamic stability and parametric stabilization of steady states of unbranched metabolic pathways.
Dibrov B, Zhabotinskiĭ A, Kholodenko B. Dynamic stability and parametric stabilization of steady states of unbranched metabolic pathways. Биофизика 1981, 26: 790-5. PMID: 7317462.Peer-Reviewed Original Research