1998
Subtleties in control by metabolic channelling and enzyme organization
Kholodenko B, Rohwer J, Cascante M, Westerhoff H. Subtleties in control by metabolic channelling and enzyme organization. Molecular And Cellular Biochemistry 1998, 184: 311-320. PMID: 9746327, DOI: 10.1023/a:1006809028612.Peer-Reviewed Original ResearchConceptsPhosphotransferase systemMetabolic control analysisBacterial phosphotransferase systemEnzyme-enzyme associationsDirect metabolite transferEnzyme organizationConcomitant phosphorylationTernary complex formationPTS pathwayMetabolite transferEnzyme sequestrationMetabolic channellingLiving cellsMacromolecular crowdingPhosphoryl groupEnzyme controlTernary complexCell functionPathwayEnzymeComplex formationIdeal systemEnzyme control coefficientsMetabolic systemsControl coefficients
1996
Molecular Control Analysis: Control within Proteins and Molecular Processes
Brown G, Westerhoff H, Kholodenko B. Molecular Control Analysis: Control within Proteins and Molecular Processes. Journal Of Theoretical Biology 1996, 182: 389-396. PMID: 8944172, DOI: 10.1006/jtbi.1996.0178.Peer-Reviewed Original ResearchParadoxical control properties of enzymes within pathways: can activation cause an enzyme to have increased control?
KHOLODENKO B, BROWN G. Paradoxical control properties of enzymes within pathways: can activation cause an enzyme to have increased control? Biochemical Journal 1996, 314: 753-760. PMID: 8615766, PMCID: PMC1217121, DOI: 10.1042/bj3140753.Peer-Reviewed Original Research
1995
Elusive control
Westerhoff H, Kholodenko B, Cascante M, Van Dam K. Elusive control. Journal Of Bioenergetics And Biomembranes 1995, 27: 491-497. PMID: 8718454, DOI: 10.1007/bf02110189.Peer-Reviewed Original ResearchEnergy, control and DNA structure in the living cell
Wijker J, Jensen P, Snoep J, Gomes A, Guiral M, Jongsma A, de Waal A, Hoving S, van Dooren S, van der Weijden C, van Workum M, van Heeswijk W, Molenaar O, Wielinga P, Richard P, Diderich J, Bakker B, Teusink B, Hemker M, Rohwer J, van der Gugten A, Kholodenko B, Westerhoff H. Energy, control and DNA structure in the living cell. Biophysical Chemistry 1995, 55: 153-165. PMID: 7632875, DOI: 10.1016/0301-4622(94)00148-d.Peer-Reviewed Original ResearchConceptsHigh ATP/ADP ratiosATP/ADP ratioCell physiologyADP ratioCertain cell typesCellular functionsIntracellular ATP levelsTransduction pathwaysDNA structureLiving cellsCell typesIon gradientsHomeostatic control mechanismsATP levelsCell functionElaborate controlPhysiologyCellsControl mechanismsMaintenanceMolecular biology for flux control
Jensen P, Snoep J, Molenaar D, van Heeswijk W, Kholodenko B, van der Gugten A, Westerhoff H. Molecular biology for flux control. Biochemical Society Transactions 1995, 23: 367-370. PMID: 7672396, DOI: 10.1042/bst0230367.Peer-Reviewed Original Research
1994
Control by Enzymes, Coenzymes and Conserved Moieties
Kholodenko B, Sauro H, Westerhoff H. Control by Enzymes, Coenzymes and Conserved Moieties. The FEBS Journal 1994, 225: 179-186. PMID: 7925436, DOI: 10.1111/j.1432-1033.1994.00179.x.Peer-Reviewed Original Research