Featured Publications
Scaffolding Protein Grb2-associated Binder 1 Sustains Epidermal Growth Factor-induced Mitogenic and Survival Signaling by Multiple Positive Feedback Loops*
Kiyatkin A, Aksamitiene E, Markevich NI, Borisov NM, Hoek JB, Kholodenko BN. Scaffolding Protein Grb2-associated Binder 1 Sustains Epidermal Growth Factor-induced Mitogenic and Survival Signaling by Multiple Positive Feedback Loops*. Journal Of Biological Chemistry 2006, 281: 19925-19938. PMID: 16687399, PMCID: PMC2312093, DOI: 10.1074/jbc.m600482200.Peer-Reviewed Original ResearchConceptsEpidermal growth factorRas/MAPK signalingGab1 tyrosine phosphorylationGrowth factorRole of Gab1PI3K/Akt activationMultiple positive feedback loopsProtein Grb2Mutant proteinsScaffold proteinTyrosine phosphorylationBinder 1Positive feedback loopMitogenic pathwaysMAPK signalingEssential functionsSurvival signalingDiverse perturbationsCellular responsesAkt activationCytokine receptorsPharmacological inhibitorsGab1EGF dosesGrb2
2004
Quantitative analysis of signaling networks
Sauro H, Kholodenko B. Quantitative analysis of signaling networks. Progress In Biophysics And Molecular Biology 2004, 86: 5-43. PMID: 15261524, DOI: 10.1016/j.pbiomolbio.2004.03.002.Peer-Reviewed Original Research
2000
Negative feedback and ultrasensitivity can bring about oscillations in the mitogen‐activated protein kinase cascades
Kholodenko B. Negative feedback and ultrasensitivity can bring about oscillations in the mitogen‐activated protein kinase cascades. The FEBS Journal 2000, 267: 1583-1588. PMID: 10712587, DOI: 10.1046/j.1432-1327.2000.01197.x.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseMAPK cascadeProtein kinaseProtein phosphorylation cascadeSlow protein diffusionNegative feedback loopPhosphorylation cascadeSignal transductionFeedback loopCellular targetsProtein diffusionMAPK phosphorylationPhosphorylation levelsCell typesIntracellular wavesKinasePhosphorylationCascadeFunctional organizationUltrasensitivityRecent kinetic dataExternal stimuliTransductionTotal proteinCytoplasm
1997
Quantification of information transfer via cellular signal transduction pathways
Kholodenko B, Hoek J, Westerhoff H, Brown G. Quantification of information transfer via cellular signal transduction pathways. FEBS Letters 1997, 414: 430-434. PMID: 9315734, DOI: 10.1016/s0014-5793(97)01018-1.Peer-Reviewed Original Research
1982
Dynamic stability of steady states and static stabilization in unbranched metabolic pathways
Dibrov B, Zhabotinsky A, Kholodenko B. Dynamic stability of steady states and static stabilization in unbranched metabolic pathways. Journal Of Mathematical Biology 1982, 15: 51-63. PMID: 7142835, DOI: 10.1007/bf00275788.Peer-Reviewed Original Research
1981
Dynamic stability and parametric stabilization of steady states of unbranched metabolic pathways.
Dibrov B, Zhabotinskiĭ A, Kholodenko B. Dynamic stability and parametric stabilization of steady states of unbranched metabolic pathways. Биофизика 1981, 26: 790-5. PMID: 7317462.Peer-Reviewed Original Research