1998
Metabolic design: How to engineer a living cell to desired metabolite concentrations and fluxes
Kholodenko B, Cascante M, Hoek J, Westerhoff H, Schwaber J. Metabolic design: How to engineer a living cell to desired metabolite concentrations and fluxes. Biotechnology And Bioengineering 1998, 59: 239-247. PMID: 10099334, DOI: 10.1002/(sici)1097-0290(19980720)59:2<239::aid-bit11>3.0.co;2-9.Peer-Reviewed Original ResearchControl analysis of metabolic systems involving quasi-equilibrium reactions
Kholodenko B, Schuster S, Garcia J, Westerhoff H, Cascante M. Control analysis of metabolic systems involving quasi-equilibrium reactions. Biochimica Et Biophysica Acta 1998, 1379: 337-352. PMID: 9545597, DOI: 10.1016/s0304-4165(97)00114-1.Peer-Reviewed Original Research
1996
Strong control on the transit time in metabolic channelling
Kholodenko B, Sakamoto N, Puigjaner J, Westerhoff H, Cascante M. Strong control on the transit time in metabolic channelling. FEBS Letters 1996, 389: 123-125. PMID: 8766813, DOI: 10.1016/0014-5793(96)00532-7.Peer-Reviewed Original ResearchParadoxical control properties of enzymes within pathways: can activation cause an enzyme to have increased control?
KHOLODENKO B, BROWN G. Paradoxical control properties of enzymes within pathways: can activation cause an enzyme to have increased control? Biochemical Journal 1996, 314: 753-760. PMID: 8615766, PMCID: PMC1217121, DOI: 10.1042/bj3140753.Peer-Reviewed Original ResearchEffect of channelling on the concentration of bulk-phase intermediates as cytosolic proteins become more concentrated
KHOLODENKO B, WESTERHOFF H, CASCANTE C. Effect of channelling on the concentration of bulk-phase intermediates as cytosolic proteins become more concentrated. Biochemical Journal 1996, 313: 921-926. PMID: 8611176, PMCID: PMC1216999, DOI: 10.1042/bj3130921.Peer-Reviewed Original Research
1995
Elusive control
Westerhoff H, Kholodenko B, Cascante M, Van Dam K. Elusive control. Journal Of Bioenergetics And Biomembranes 1995, 27: 491-497. PMID: 8718454, DOI: 10.1007/bf02110189.Peer-Reviewed Original ResearchControl analysis of transit time for free and enzyme-bound metabolites: physiological and evolutionary significance of metabolic response times
Cascante M, Meléndez-Hevia E, Kholodenko B, Sicilia J, Kacser H. Control analysis of transit time for free and enzyme-bound metabolites: physiological and evolutionary significance of metabolic response times. Biochemical Journal 1995, 308: 895-899. PMID: 8948448, PMCID: PMC1136808, DOI: 10.1042/bj3080895.Peer-Reviewed Original ResearchMolecular biology for flux control
Jensen P, Snoep J, Molenaar D, van Heeswijk W, Kholodenko B, van der Gugten A, Westerhoff H. Molecular biology for flux control. Biochemical Society Transactions 1995, 23: 367-370. PMID: 7672396, DOI: 10.1042/bst0230367.Peer-Reviewed Original ResearchCoenzyme cycles and metabolic control analysis: the determination of the elasticity coefficients from the generalised connectivity theorem.
Kholodenko B, Sauro H, Westerhoff H, Cascante M. Coenzyme cycles and metabolic control analysis: the determination of the elasticity coefficients from the generalised connectivity theorem. IUBMB Life 1995, 35: 615-25. PMID: 7773196.Peer-Reviewed Original ResearchControl theory of metabolic channelling
Kholodenko B, Cascante M, Westerhoff H. Control theory of metabolic channelling. Molecular And Cellular Biochemistry 1995, 143: 151-168. PMID: 7596350, DOI: 10.1007/bf01816949.Peer-Reviewed Original Research
1994
Control theory of one enzyme
Kholodenko B, Westerhoff H. Control theory of one enzyme. Biochimica Et Biophysica Acta 1994, 1208: 294-305. PMID: 7947961, DOI: 10.1016/0167-4838(94)90116-3.Peer-Reviewed Original ResearchConceptsEnzyme catalytic cycleArbitrary kinetic schemesEnzyme catalyzed reactionsStandard free energy differenceControl of reactionsCatalytic cycleElemental stepsFree energy differenceCatalyzed reactionsFree energy dropForward rate constantElemental transitionsReaction rateEnzyme reactionRate constantsEnergy differenceEnzyme statesKinetic schemeReactionEnzyme cycleSingle enzymeEnzymeStepKineticsConstantsControl by Enzymes, Coenzymes and Conserved Moieties
Kholodenko B, Sauro H, Westerhoff H. Control by Enzymes, Coenzymes and Conserved Moieties. The FEBS Journal 1994, 225: 179-186. PMID: 7925436, DOI: 10.1111/j.1432-1033.1994.00179.x.Peer-Reviewed Original ResearchRate limitation within a single enzyme is directly related to enzyme intermediate levels
Kholodenko B, Westerhoff H, Brown G. Rate limitation within a single enzyme is directly related to enzyme intermediate levels. FEBS Letters 1994, 349: 131-134. PMID: 8045290, DOI: 10.1016/0014-5793(94)00617-2.Peer-Reviewed Original ResearchGetting to the inside of cells using metabolic control analysis
Westerhoff H, Hofmeyr J, Kholodenko B. Getting to the inside of cells using metabolic control analysis. Biophysical Chemistry 1994, 50: 273-283. PMID: 8011948, DOI: 10.1016/0301-4622(93)e0095-m.Peer-Reviewed Original Research
1993
Dramatic changes in control properties that accompany channelling and metabolite sequestration
Kholodenko B, Cascante M, Westerhoff H. Dramatic changes in control properties that accompany channelling and metabolite sequestration. FEBS Letters 1993, 336: 381-384. PMID: 8282097, DOI: 10.1016/0014-5793(93)80841-h.Peer-Reviewed Original Research‘Channelled’ pathways can be more sensitive to specific regulatory signals
Kholodenko B, Demin O, Westerhoff H. ‘Channelled’ pathways can be more sensitive to specific regulatory signals. FEBS Letters 1993, 320: 75-78. PMID: 8462681, DOI: 10.1016/0014-5793(93)81661-i.Peer-Reviewed Original ResearchMetabolic channelling and control of the flux
Kholodenko B, Westerhoff H. Metabolic channelling and control of the flux. FEBS Letters 1993, 320: 71-74. PMID: 8462680, DOI: 10.1016/0014-5793(93)81660-r.Peer-Reviewed Original ResearchThe sum of the control coefficients of all enzymes on the flux through a group‐transfer pathway can be as high as two
van DAM K, van der VLAG J, KHOLODENKO B, WESTERHOFF H. The sum of the control coefficients of all enzymes on the flux through a group‐transfer pathway can be as high as two. The FEBS Journal 1993, 212: 791-799. PMID: 8462550, DOI: 10.1111/j.1432-1033.1993.tb17720.x.Peer-Reviewed Original ResearchConceptsGroup-transfer pathwaysReaction activityDissociation rate constantsElectron transfer chainAcceptor couplesEnzyme-enzyme interactionsEnzyme concentrationRate constantsEnzyme-enzyme complexEnzyme interactionsComplexesControl of enzymesEnzyme complexEnzymeConcentrationBacterial phosphoenolpyruvateMain pathwayInteractionConstantsChainControl analysisSimple metabolic pathwaysSugar phosphotransferase system
1992
Control of the metabolic flux in a system with high enzyme concentrations and moiety‐conserved cycles
KHOLODENKO B, LYUBAREV A, KURGANOV B. Control of the metabolic flux in a system with high enzyme concentrations and moiety‐conserved cycles. The FEBS Journal 1992, 210: 147-153. PMID: 1446668, DOI: 10.1111/j.1432-1033.1992.tb17402.x.Peer-Reviewed Original ResearchEnzymesModels, Theoretical
1989
Theory of metabolism regulation: a complete system of equations for regulation coefficients.
Kholodenko B, Erlikh L. Theory of metabolism regulation: a complete system of equations for regulation coefficients. Биофизика 1989, 34: 802-7. PMID: 2611277.Peer-Reviewed Original Research