Systems biology‐embedded target validation: improving efficacy in drug discovery
Vandamme D, Minke BA, Fitzmaurice W, Kholodenko BN, Kolch W. Systems biology‐embedded target validation: improving efficacy in drug discovery. WIREs Mechanisms Of Disease 2013, 6: 1-11. PMID: 24214316, DOI: 10.1002/wsbm.1253.Peer-Reviewed Original ResearchConceptsSystems biology approachBiology approachDrug discoveryPotential drug targetsOmics technologiesMolecular mechanismsMultidrug treatmentDrug targetsMedical treatmentNovel targetDrug pipelineDrug developmentEfficacyAttrition ratesTreatmentDiscoveryGreater personalizationReductionist modelPatientsSystems medicine: helping us understand the complexity of disease
Vandamme D, Fitzmaurice W, Kholodenko B, Kolch W. Systems medicine: helping us understand the complexity of disease. QJM 2013, 106: 891-895. PMID: 23904523, DOI: 10.1093/qjmed/hct163.Peer-Reviewed Original Research