1998
Metabolic design: How to engineer a living cell to desired metabolite concentrations and fluxes
Kholodenko B, Cascante M, Hoek J, Westerhoff H, Schwaber J. Metabolic design: How to engineer a living cell to desired metabolite concentrations and fluxes. Biotechnology And Bioengineering 1998, 59: 239-247. PMID: 10099334, DOI: 10.1002/(sici)1097-0290(19980720)59:2<239::aid-bit11>3.0.co;2-9.Peer-Reviewed Original ResearchControl analysis of metabolic systems involving quasi-equilibrium reactions
Kholodenko B, Schuster S, Garcia J, Westerhoff H, Cascante M. Control analysis of metabolic systems involving quasi-equilibrium reactions. Biochimica Et Biophysica Acta 1998, 1379: 337-352. PMID: 9545597, DOI: 10.1016/s0304-4165(97)00114-1.Peer-Reviewed Original Research
1995
Composite control of cell function: metabolic pathways behaving as single control units
Kholodenko B, Schuster S, Rohwer J, Cascante M, Westerhoff H. Composite control of cell function: metabolic pathways behaving as single control units. FEBS Letters 1995, 368: 1-4. PMID: 7615057, DOI: 10.1016/0014-5793(95)00562-n.Peer-Reviewed Original ResearchEnergy, control and DNA structure in the living cell
Wijker J, Jensen P, Snoep J, Gomes A, Guiral M, Jongsma A, de Waal A, Hoving S, van Dooren S, van der Weijden C, van Workum M, van Heeswijk W, Molenaar O, Wielinga P, Richard P, Diderich J, Bakker B, Teusink B, Hemker M, Rohwer J, van der Gugten A, Kholodenko B, Westerhoff H. Energy, control and DNA structure in the living cell. Biophysical Chemistry 1995, 55: 153-165. PMID: 7632875, DOI: 10.1016/0301-4622(94)00148-d.Peer-Reviewed Original ResearchConceptsHigh ATP/ADP ratiosATP/ADP ratioCell physiologyADP ratioCertain cell typesCellular functionsIntracellular ATP levelsTransduction pathwaysDNA structureLiving cellsCell typesIon gradientsHomeostatic control mechanismsATP levelsCell functionElaborate controlPhysiologyCellsControl mechanismsMaintenanceThe macroworld versus the microworld of biochemical regulation and control
Kholodenko B, Westerhoff H. The macroworld versus the microworld of biochemical regulation and control. Trends In Biochemical Sciences 1995, 20: 52-54. PMID: 7701560, DOI: 10.1016/s0968-0004(00)88955-0.Peer-Reviewed Original Research
1994
Getting to the inside of cells using metabolic control analysis
Westerhoff H, Hofmeyr J, Kholodenko B. Getting to the inside of cells using metabolic control analysis. Biophysical Chemistry 1994, 50: 273-283. PMID: 8011948, DOI: 10.1016/0301-4622(93)e0095-m.Peer-Reviewed Original Research