2013
Systems biology‐embedded target validation: improving efficacy in drug discovery
Vandamme D, Minke BA, Fitzmaurice W, Kholodenko BN, Kolch W. Systems biology‐embedded target validation: improving efficacy in drug discovery. WIREs Mechanisms Of Disease 2013, 6: 1-11. PMID: 24214316, DOI: 10.1002/wsbm.1253.Peer-Reviewed Original ResearchConceptsSystems biology approachBiology approachDrug discoveryPotential drug targetsOmics technologiesMolecular mechanismsMultidrug treatmentDrug targetsMedical treatmentNovel targetDrug pipelineDrug developmentEfficacyAttrition ratesTreatmentDiscoveryGreater personalizationReductionist modelPatients
1982
Optical tactics of antibacterial therapy for the trigger model of the infection process.
Kholodenko B, Geviksman K, Kholodov L. Optical tactics of antibacterial therapy for the trigger model of the infection process. Биофизика 1982, 27: 900-5. PMID: 7138944.Peer-Reviewed Original Research