2000
Why cytoplasmic signalling proteins should be recruited to cell membranes
Kholodenko B, Hoek J, Westerhoff H, Kholodenko B, Hoek J, Westerhoff H. Why cytoplasmic signalling proteins should be recruited to cell membranes. Trends In Cell Biology 2000, 10: 173-178. PMID: 10754559, DOI: 10.1016/s0962-8924(00)01741-4.Peer-Reviewed Original ResearchConceptsSignal transduction proteinsSignal transduction chainTransduction proteinsCytoplasmic signaling proteinsMembrane localizationAdaptor proteinSignaling proteinsMembrane proteinsSignal transductionPlasma membraneRate of encounterImportant structural constraintsCell membraneProteinExtent of activationMembraneNumber of complexesDownstream processesActivationLocalizationTransductionReceptorsStructural constraintsLow concentrationsComplexesNegative feedback and ultrasensitivity can bring about oscillations in the mitogen‐activated protein kinase cascades
Kholodenko B. Negative feedback and ultrasensitivity can bring about oscillations in the mitogen‐activated protein kinase cascades. The FEBS Journal 2000, 267: 1583-1588. PMID: 10712587, DOI: 10.1046/j.1432-1327.2000.01197.x.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseMAPK cascadeProtein kinaseProtein phosphorylation cascadeSlow protein diffusionNegative feedback loopPhosphorylation cascadeSignal transductionFeedback loopCellular targetsProtein diffusionMAPK phosphorylationPhosphorylation levelsCell typesIntracellular wavesKinasePhosphorylationCascadeFunctional organizationUltrasensitivityRecent kinetic dataExternal stimuliTransductionTotal proteinCytoplasmCellular information transfer regarded from a stoichiometry and control analysis perspective
Schuster S, Kholodenko B, Westerhoff H. Cellular information transfer regarded from a stoichiometry and control analysis perspective. Biosystems 2000, 55: 73-81. PMID: 10745111, DOI: 10.1016/s0303-2647(99)00085-4.Peer-Reviewed Original ResearchMetabolic Control From The Back Benches: Biochemistry Towards Biocomplexity
Westerhoff H, Teusink B, Mensonides F, Reijenga K, Esgalhado E, Kholodenko B, Somsen O, Van Heeswijk W, Boogerd F, Bruggeman F, Snoep J. Metabolic Control From The Back Benches: Biochemistry Towards Biocomplexity. NATO Science Partnership Subseries: 3 2000, 235-242. DOI: 10.1007/978-94-011-4072-0_26.Peer-Reviewed Original ResearchBacterial inner membraneElectron transfer chainImportant metabolic processesBiological free energy transductionFermentation of glucoseInner membraneATP hydrolysisPhysiological processesMetabolic processesMolecular biologyProton pumpLiving cellsStudy of metabolismProtein fractionsBiochemical reactionsIndependent chemical reactionsFree energy transductionBiochemistryChemical reactionsTransductionYeastBiocomplexityReactionBiologySubstantial progress
1996
Direct Transfer of Control and Multidrug Resistance
Westerhoff H, Rohwer J, Heijn M, Mülder S, Ghauharali R, Wielinga P, Kholodenko B, Spoelstra E, Lankelma J. Direct Transfer of Control and Multidrug Resistance. NATO Science Series A: 1996, 283-292. DOI: 10.1007/978-1-4615-5845-3_29.Peer-Reviewed Original ResearchPhosphotransferase systemIntact cellsBacterial phosphotransferase systemPlasma membrane vesiclesCellular processesPTS enzymesSignal transductionPlasma membraneKinetic propertiesMultidrug pumpMembrane vesiclesIntracellular daunorubicin concentrationMultidrug resistanceIntricate organizationP-glycoproteinModel systemIntact systemDrug effluxDrug pumpCellsPassive permeabilityDirect transferTransductionDistribution of controlDNA