Modeling the Nonlinear Dynamics of Intracellular Signaling Networks
Rukhlenko O, Kholodenko B. Modeling the Nonlinear Dynamics of Intracellular Signaling Networks. Bio-protocol 2021, 11: e4089. PMID: 34395728, PMCID: PMC8329461, DOI: 10.21769/bioprotoc.4089.Peer-Reviewed Original ResearchOrdinary differential equationsPartial differential equation systemDifferential equation systemDifferent dynamical regimesBasins of attractionMain qualitative featuresDifferential equationsState trajectoriesEquation systemSystem trajectoriesDynamical regimesNonlinear dynamicsStable steady stateSteady stateBifurcation analysisParameter spaceLimit cyclesMultiple attractorsConstant parametersParametric planePoint dynamicsStandard optimizationIntracellular signaling networksSpatial pointsMultiple steady states