2013
Complexity of Receptor Tyrosine Kinase Signal Processing
Volinsky N, Kholodenko BN. Complexity of Receptor Tyrosine Kinase Signal Processing. Cold Spring Harbor Perspectives In Biology 2013, 5: a009043. PMID: 23906711, PMCID: PMC3721286, DOI: 10.1101/cshperspect.a009043.Peer-Reviewed Original ResearchConceptsCombinatorial varietySignal processingMathematical modelingSpecific system propertiesSpecific cell fate decisionsSystem propertiesNetwork behaviorReceptor tyrosine kinasesMultiple feedsSpatiotemporal dynamicsComputational approachExcitable responseIntricate landscapeCell fate decisionsSpecific cellular outcomesPathway cross talkOscillationsBistabilityNetwork circuitryDynamicsModelingTranscriptional controlAdapts cellsCellular outcomes
2002
Control Analysis for Autonomously Oscillating Biochemical Networks
Reijenga K, Westerhoff H, Kholodenko B, Snoep J. Control Analysis for Autonomously Oscillating Biochemical Networks. Biophysical Journal 2002, 82: 99-108. PMID: 11751299, PMCID: PMC1302452, DOI: 10.1016/s0006-3495(02)75377-0.Peer-Reviewed Original ResearchConceptsSummation theoremYeast glycolytic oscillationsLimit cycle oscillationsDynamic systemsControl coefficientsBiochemical networksCycle oscillationsOscillatory propertiesControl analysisMetabolic control analysisTheoremGlycolytic oscillationsTime domainOscillationsModel outputDiscrete Fourier transformFrequency domainSteady stateData setsQualitative way
1996
Control analysis of glycolytic oscillations
Bier M, Teusink B, Kholodenko B, Westerhoff H. Control analysis of glycolytic oscillations. Biophysical Chemistry 1996, 62: 15-24. PMID: 8962468, DOI: 10.1016/s0301-4622(96)02195-3.Peer-Reviewed Original ResearchControl of Dynamics and Steady State: Applications to Multidrug Resistance
Westerhoff H, Bier M, Molenaar D, Spoelstra E, Lankelma J, Jongsma A, Jensen P, Richard P, Kholodenko B. Control of Dynamics and Steady State: Applications to Multidrug Resistance. 1996, 25-31. DOI: 10.1007/978-3-322-85017-1_3.Peer-Reviewed Original Research