2015
Network-based identification of feedback modules that control RhoA activity and cell migration
Kim TH, Monsefi N, Song JH, von Kriegsheim A, Vandamme D, Pertz O, Kholodenko BN, Kolch W, Cho KH. Network-based identification of feedback modules that control RhoA activity and cell migration. Journal Of Molecular Cell Biology 2015, 7: 242-252. PMID: 25780058, DOI: 10.1093/jmcb/mjv017.Peer-Reviewed Original ResearchConceptsRho family GTPasesCancer cell migrationCell migrationRhoA activityControl cell migrationBoolean network modelNetwork-based identificationPotential new targetsRho activationGTPasesSrc inhibitionGenetic backgroundCsk inhibitionMost cancer deathsActivation stateNew targetsNew insightsMigrationCskSrcFAKRewiringInhibitionEGFProtrusion
2005
Mechanistic and modular approaches to modeling and inference of cellular regulatory networks
Kholodenko B, Bruggeman F, Sauro H. Mechanistic and modular approaches to modeling and inference of cellular regulatory networks. Topics In Current Genetics 2005, 13: 143-159. DOI: 10.1007/b136809.Peer-Reviewed Original ResearchReaction-diffusion equationsCellular regulatory networksRegulatory networksSystems biologyMolecular mechanismsBiochemical networksNetwork inferencePhysiological responsesNew insightsModeling approachChemical kineticsInferenceMolecular dynamics simulationsEquationsModelingBiologyComputational modelingNetworkModular approachDynamics simulationsApproachSimulationsNovel approach