2013
Complexity of Receptor Tyrosine Kinase Signal Processing
Volinsky N, Kholodenko BN. Complexity of Receptor Tyrosine Kinase Signal Processing. Cold Spring Harbor Perspectives In Biology 2013, 5: a009043. PMID: 23906711, PMCID: PMC3721286, DOI: 10.1101/cshperspect.a009043.Peer-Reviewed Original ResearchConceptsCombinatorial varietySignal processingMathematical modelingSpecific system propertiesSpecific cell fate decisionsSystem propertiesNetwork behaviorReceptor tyrosine kinasesMultiple feedsSpatiotemporal dynamicsComputational approachExcitable responseIntricate landscapeCell fate decisionsSpecific cellular outcomesPathway cross talkOscillationsBistabilityNetwork circuitryDynamicsModelingTranscriptional controlAdapts cellsCellular outcomes
2005
Mechanistic and modular approaches to modeling and inference of cellular regulatory networks
Kholodenko B, Bruggeman F, Sauro H. Mechanistic and modular approaches to modeling and inference of cellular regulatory networks. Topics In Current Genetics 2005, 13: 143-159. DOI: 10.1007/b136809.Peer-Reviewed Original ResearchReaction-diffusion equationsCellular regulatory networksRegulatory networksSystems biologyMolecular mechanismsBiochemical networksNetwork inferencePhysiological responsesNew insightsModeling approachChemical kineticsInferenceMolecular dynamics simulationsEquationsModelingBiologyComputational modelingNetworkModular approachDynamics simulationsApproachSimulationsNovel approach