2007
Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses
Birtwistle MR, Hatakeyama M, Yumoto N, Ogunnaike BA, Hoek JB, Kholodenko BN. Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses. Molecular Systems Biology 2007, 3: msb4100188. PMID: 18004277, PMCID: PMC2132449, DOI: 10.1038/msb4100188.Peer-Reviewed Original ResearchMeSH KeywordsAndrostadienesButadienesCell Line, TumorCell MembraneDimerizationEnzyme ActivationEpidermal Growth FactorExtracellular Signal-Regulated MAP KinasesFeedback, PhysiologicalHumansLigandsModels, BiologicalNeuregulin-1NitrilesPhosphoinositide-3 Kinase InhibitorsPhosphorylationProtein Structure, TertiaryProto-Oncogene Proteins c-aktReceptor Protein-Tyrosine KinasesReproducibility of ResultsSignal TransductionWortmanninConceptsEpidermal growth factorERK activityEGF-induced signalingMultiple human cancersPhosphoinositol-3 kinaseLigand-dependent responsesSustained signalingERK activationDownstream proteinsAkt activationInhibitor U0126Major regulatorHuman cancersErbB receptorsLigand dosesHeregulinErbBKinaseSignalingGrowth factorActivationKey roleU0126AktRegulator
1988
The role of adenine nucleotide translocator in the regulation of oxidative phosphorylation in heart mitochondria.
Kholodenko B, Zhilinskene V, Borutaĭte V, Ivanovene L, Toleĭkis A. The role of adenine nucleotide translocator in the regulation of oxidative phosphorylation in heart mitochondria. Биохимия 1988, 53: 1009-12. PMID: 2846076.Peer-Reviewed Original ResearchConceptsAdenine nucleotide translocaseOxidative phosphorylationNucleotide translocaseADP/ATP translocaseHeart mitochondriaATP translocaseTitration of respirationTranslocaseRegulatory rolePhosphorylationRabbit heart mitochondriaMitochondriaRespiration rateRole of adenineRegulationRespirationKey roleState 3TranslocatorRoleCarboxyatractylosideControl coefficientsADP
1987
The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria
Kholodenko B, Z̆ilinskie·e V, Borutait·e V, Ivanovien·e L, Toleikis A, Pras̆kevic̆ius A. The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria. FEBS Letters 1987, 223: 247-250. PMID: 2822484, DOI: 10.1016/0014-5793(87)80298-3.Peer-Reviewed Original ResearchConceptsAdenine nucleotide translocatorOxidative phosphorylationNucleotide translocatorHeart mitochondriaRespiration rateTitration of respirationPhosphorylationTranslocatorRabbit heart mitochondriaMitochondriaRegulative roleState 4RegulationKey roleState 3RoleCarboxyatractylosideRespirationControl coefficientsADP
1984
Control of mitochondrial oxidative phosphorylation
Kholodenko B. Control of mitochondrial oxidative phosphorylation. Journal Of Theoretical Biology 1984, 107: 179-188. PMID: 6717037, DOI: 10.1016/s0022-5193(84)80020-x.Peer-Reviewed Original Research