2024
Financial Compensation of Academic Otolaryngologists in the United States: Trends and Distribution
Shah R, Tyagi S, Futela D, Malhotra A, Judson B. Financial Compensation of Academic Otolaryngologists in the United States: Trends and Distribution. The Laryngoscope 2024 PMID: 39530275, DOI: 10.1002/lary.31909.Peer-Reviewed Original ResearchSalary survey dataMedian compensationFinancial compensationAcademic medical centerCompensation dataFaculty compensationSalary surveySalary gapSalary inequitiesSurvey dataMedical CenterFaculty membersSenior ranksAcademic otolaryngology departmentUnited StatesUS academic centersGeographic regionsFinancialFull-time facultyCompensationLaryngeal rare benign non-epithelial tumors and sarcomas emphasizing on chondrosarcomas: A literature review and a case presentation
Vageli D, Doukas P, Paraskeva A, ZACHAROULI K, Judson B, IOANNOU M. Laryngeal rare benign non-epithelial tumors and sarcomas emphasizing on chondrosarcomas: A literature review and a case presentation. Pathology - Research And Practice 2024, 261: 155512. PMID: 39116572, DOI: 10.1016/j.prp.2024.155512.Peer-Reviewed Original ResearchRare tumorNon-epithelialLaryngeal chondrosarcomaMalignant tumorsMesenchymal originBenign non-epithelial tumorsNon-epithelial benign tumorsRare laryngeal tumorNon-epithelial tumorsHigh-grade tumorsLow-grade neoplasmsMesenchymal malignant tumorCases of LCMesenchymal entityRare malignancyEpithelial tumorsMesenchymal tumorsBenign tumorsS100 markersLaryngeal tumorsPrognostic markerLaryngeal malignanciesLaryngeal sarcomasPathological entitySarcoma StudyDiscovering Novel and Unique Saliva and Serum miRNA and mRNA Signatures for Oral Cancer Detection Using Whole Transcriptome and Small Non-Coding RNA Sequencing: Prediction of Their Association With the PI3K/AKT Pathway
Vageli D, Doukas P, Judson B. Discovering Novel and Unique Saliva and Serum miRNA and mRNA Signatures for Oral Cancer Detection Using Whole Transcriptome and Small Non-Coding RNA Sequencing: Prediction of Their Association With the PI3K/AKT Pathway. JCO Global Oncology 2024, 10: 52-52. DOI: 10.1200/go-24-47000.Peer-Reviewed Original ResearchSerum miRNAsPanel of miRNAsHsa-miR-7704Oral squamous cell carcinomaSmall non-coding RNA sequencesHealthy controlsSerum of OSCC patientsMiRNAsMRNA markersOral cavity cancer patientsMRNA signatureDetection of oral cancerOral cavity cancerIdentification of molecular biomarkersSquamous cell carcinomaNon-invasive biomarkersSerum samplesUnique miRNAsOral cancer detectionPost-treatment monitoringCell carcinomaOral cancerNon-coding RNA sequencesOSCC patientsCancer patientsAssociation of Medical School Gap Year Research and Degree Programs With Otolaryngology Interview and Match Outcomes
Boyi T, Benjamin W, Lenze N, Brenner M, Mihalic A, Kupfer R, Judson B, Lee Y. Association of Medical School Gap Year Research and Degree Programs With Otolaryngology Interview and Match Outcomes. Annals Of Otology Rhinology & Laryngology 2024, 133: 783-791. PMID: 38887016, DOI: 10.1177/00034894241261821.Peer-Reviewed Original ResearchLong-term career outcomesCross-sectional analysisApplicant respondentsMedical schoolsPrimary outcomeResidency interviewsLongitudinal studyUSMLE scoresInterviewsOtolaryngologyTexas Seeking TransparencyMaster's degreeNo significant differenceOutcomesMatch successGap yearDegree programsYearsSignificant differenceClerkship honorsOtolaryngology applicantsResearch experienceNovel non‐invasive molecular signatures for oral cavity cancer, by whole transcriptome and small non‐coding RNA sequencing analyses: Predicted association with PI3K/AKT/mTOR pathway
Vageli D, Doukas P, Townsend J, Pickering C, Judson B. Novel non‐invasive molecular signatures for oral cavity cancer, by whole transcriptome and small non‐coding RNA sequencing analyses: Predicted association with PI3K/AKT/mTOR pathway. Cancer Medicine 2024, 13: e7309. PMID: 38819439, PMCID: PMC11141334, DOI: 10.1002/cam4.7309.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorCarcinoma, Squamous CellCase-Control StudiesFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMicroRNAsMiddle AgedMouth NeoplasmsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, MessengerRNA, Small UntranslatedSalivaSequence Analysis, RNASignal TransductionTOR Serine-Threonine KinasesTranscriptomeConceptsOral squamous cell carcinomaPost-treatment monitoringHealthy controlsOral cavity cancer patientsOral cavity cancerIdentification of molecular biomarkersSquamous cell carcinomaPatients relative to HCSamples of salivaMonitoring of patientsCell carcinomaPost-treatment monitoring of patientsSmoking historySerum miRNAsCancer patientsEfficient clinical toolEffective preventive careTherapeutic approachesMRNA signatureRNA sequencing analysisClinical testingSerumPatientsMolecular biomarkersClinical toolIdentifying Opportunities to Deliver High‐Quality Cancer Care Across a Health System: A Clinical Responsibility
Shah H, Cohen O, Bourdillon A, Burtness B, Boffa D, Young M, Judson B, Mehra S. Identifying Opportunities to Deliver High‐Quality Cancer Care Across a Health System: A Clinical Responsibility. Otolaryngology 2024, 171: 445-456. PMID: 38606669, DOI: 10.1002/ohn.755.Peer-Reviewed Original ResearchOral squamous cell carcinomaHealth systemCancer careLymph node yieldDeliver high-quality cancer careHigh-quality cancer careBaseline quality of careReporting of Observational StudiesFragmentation of careQuality of careFacility typeCommunity facilitiesOdds of positive surgical marginsAssociated with increased oddsPositive surgical margin rateCombination groupAcademic centersPositive surgical marginsTreating facility typeSurgical margin ratePrimary outcome measureSquamous cell carcinomaGuideline-adherent treatmentCombined careEpidemiology guidelinesImpact of 18F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning–Generated Biomarkers
Haider S, Zeevi T, Sharaf K, Gross M, Mahajan A, Kann B, Judson B, Prasad M, Burtness B, Aboian M, Canis M, Reichel C, Baumeister P, Payabvash S. Impact of 18F-FDG PET Intensity Normalization on Radiomic Features of Oropharyngeal Squamous Cell Carcinomas and Machine Learning–Generated Biomarkers. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266637. PMID: 38514087, DOI: 10.2967/jnumed.123.266637.Peer-Reviewed Original ResearchOropharyngeal squamous cell carcinomaSquamous cell carcinomaHuman papillomavirusRadiomic featuresIntraclass correlation coefficientCell carcinomaLentiform nucleusHuman papillomavirus statusReceiver-operating-characteristic analysisReceiver-operating-characteristic curvePET radiomic featuresUnivariate logistic regressionF-FDGPrimary tumorTraining cohortValidation cohortRadiomic biomarkersUnivariate analysisInterindividual comparabilityPredictive valueDegree of reproducibilityMedian areaRadiomic markersLogistic regressionAUC
2023
Cost-effectiveness of hypothetical miRNA biomarker testing for post-treatment surveillance of HPV-negative OPSCC
Shah R, Tyagi S, Vageli D, Judson B. Cost-effectiveness of hypothetical miRNA biomarker testing for post-treatment surveillance of HPV-negative OPSCC. Oral Oncology Reports 2023, 8: 100122. DOI: 10.1016/j.oor.2023.100122.Peer-Reviewed Original ResearchA Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study.
Vageli D, Doukas P, Shah R, Boyi T, Liu C, Judson B. A Novel Saliva and Serum miRNA Panel as a Potential Useful Index for Oral Cancer and the Association of miR-21 with Smoking History: a Pilot Study. Cancer Prevention Research 2023, 16: 653-659. PMID: 37683274, DOI: 10.1158/1940-6207.capr-23-0219.Peer-Reviewed Original ResearchConceptsOral squamous cell carcinomaSerum miR-21Oral cancerMiR-136MiR-21Smoking historyPilot studySerum miRNAsEarly-stage oral squamous cell carcinomaMiR-29bSquamous cell carcinomaEarly malignant lesionsEarly-stage tumorsSerum miRNA panelFurther validationUseful indexSmoking statusCell carcinomaHealthy controlsPoor survivalTobacco useHealthy volunteersLarge cohortMalignant lesionsSmokersExtra imaging beyond NCCN surveillance guidelines is cost effective for HPV− but not HPV+ oropharyngeal cancer
Shah R, Tyagi S, Liu C, Judson B. Extra imaging beyond NCCN surveillance guidelines is cost effective for HPV− but not HPV+ oropharyngeal cancer. Oral Oncology 2023, 146: 106564. PMID: 37672950, DOI: 10.1016/j.oraloncology.2023.106564.Peer-Reviewed Original ResearchASO Visual Abstract: The Representation of Surgery in Oncology Clinical Trials: 2001–2022
Shah R, Boffa D, Khan S, Judson B. ASO Visual Abstract: The Representation of Surgery in Oncology Clinical Trials: 2001–2022. Annals Of Surgical Oncology 2023, 30: 7325-7326. DOI: 10.1245/s10434-023-14125-8.Peer-Reviewed Original ResearchAssociation of Age and Frailty With 30‐Day Outcomes Among Patients Undergoing Oral Cavity Cancer Surgery
Boyi T, Williams L, Kafle S, Roche A, Judson B. Association of Age and Frailty With 30‐Day Outcomes Among Patients Undergoing Oral Cavity Cancer Surgery. Otolaryngology 2023, 169: 1523-1532. PMID: 37595108, DOI: 10.1002/ohn.476.Peer-Reviewed Original ResearchConceptsNational Quality Improvement Program databaseFrailty index scoreAdverse eventsSurgeons National Quality Improvement Program databaseIndex scoreOral cavity cancer surgeryQuality Improvement Program databaseRetrospective cross-sectional analysisHigher mFI scoresPostoperative adverse eventsImprovement Program databaseChronic obstructive diseaseCongestive heart failureFree flap reconstructionAssociation of ageImpact of ageCross-sectional analysisMore comorbiditiesOSCC resectionAnesthesiologists classificationPerioperative outcomesComposite resectionNeck dissectionHeart failureMFI scoreThe Representation of Surgery in Oncology Clinical Trials: 2001 to 2022
Shah R, Boffa D, Khan S, Judson B. The Representation of Surgery in Oncology Clinical Trials: 2001 to 2022. Annals Of Surgical Oncology 2023, 30: 7275-7280. PMID: 37556010, DOI: 10.1245/s10434-023-14064-4.Peer-Reviewed Original ResearchOver‐The‐Counter Hearing Aids: Trends in Information‐Seeking Behavior
Panth N, Shah R, Judson B, Schwartz N. Over‐The‐Counter Hearing Aids: Trends in Information‐Seeking Behavior. Otolaryngology 2023, 169: 1691-1693. PMID: 37365970, DOI: 10.1002/ohn.406.Peer-Reviewed Original ResearchPrognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma
Shah R, Liu C, Shah H, Judson B. Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma. Laryngoscope Investigative Otolaryngology 2023, 8: 870-875. PMID: 37621277, PMCID: PMC10446262, DOI: 10.1002/lio2.1094.Peer-Reviewed Original ResearchOral cavity squamous cell carcinomaAbsolute lymphocyte countOral cavity cancerSquamous cell carcinomaRate of deathLikelihood of recurrenceLymphocyte countPrognostic valueCell carcinomaCancer patientsPreoperative absolute lymphocyte countPretreatment absolute lymphocyte countLate-stage cancer patientsRetrospective chart reviewAmerican Joint CommitteeDay of surgeryEarly-stage cancer patientsTumor registry dataAdjuvant therapyOutcome patientsChart reviewPrimary outcomeALC valuesPositive marginsPrognostic indicatorImproving Post-procedure Outcomes With Clinical Care Pathway for Enteral Access
Miller S, Abou-Azar S, Owusu K, Judson B, Rhodes D, Morton J. Improving Post-procedure Outcomes With Clinical Care Pathway for Enteral Access. The American Surgeon 2023, 89: 6362-6365. PMID: 37203186, DOI: 10.1177/00031348231177914.Peer-Reviewed Original Research
2022
Trends in Residency Applicant Volume in Otolaryngology-Head and Neck Surgery and Peer Specialties
Bourdillon AT, Salehi PP, Wride M, Salehi P, Torabi S, Heiser A, Shah HP, Azizzadeh B, Judson B, Lee YH. Trends in Residency Applicant Volume in Otolaryngology-Head and Neck Surgery and Peer Specialties. Annals Of Otology Rhinology & Laryngology 2022, 132: 895-904. PMID: 36031814, DOI: 10.1177/00034894221120303.Peer-Reviewed Original ResearchConceptsNeck surgeryOtolaryngology-HeadGeneral surgeryOrthopedic surgeryRetrospective data analysisCOVID-19 pandemicAPP ratioReconstructive surgerySurgeryElectronic Residency Application ServiceNeurological surgeryNational Residency Matching ProgramSmall specialtyDermatologySpecialtiesResidency application cycleIntegrated pathwaysPandemicOHNSThe Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence
Doukas SG, Vageli DP, Doukas PG, Nikitovic D, Tsatsakis A, Judson BL. The Effect of Tobacco Smoke N-Nitrosamines, NNK and NDEA, and Nicotine, on DNA Mismatch Repair Mechanism and miRNA Markers, in Hypopharyngeal Squamous Cell Carcinoma: An In Vivo Model and Clinical Evidence. Current Oncology 2022, 29: 5531-5549. PMID: 36005175, PMCID: PMC9406897, DOI: 10.3390/curroncol29080437.Peer-Reviewed Original ResearchConceptsHypopharyngeal squamous cell carcinomaSquamous cell carcinomaClinical evidenceCell carcinomaTobacco smokeChronic exposureUpper aerodigestive tract cancerHuman hypopharyngeal squamous cell carcinomaAerodigestive tract cancerUpper aerodigestive tract carcinogenesisAerodigestive tract carcinogenesisDose-dependent effectDNA mismatch repair mechanismHypopharyngeal cellsTract cancerTobacco smokersPoor prognosisHypopharyngeal mucosaMouse modelClinical testingVivo modelMiR-155MiR-451aVivo dose-dependent effectMismatch repair mechanismThe Role of PARP‐1 and NF‐κB in Bile‐Induced DNA Damage and Oncogenic Profile in Hypopharyngeal Cells
Doukas PG, Vageli DP, Judson BL. The Role of PARP‐1 and NF‐κB in Bile‐Induced DNA Damage and Oncogenic Profile in Hypopharyngeal Cells. The Laryngoscope 2022, 133: 1146-1155. PMID: 35791892, DOI: 10.1002/lary.30284.Peer-Reviewed Original ResearchConceptsHypopharyngeal cellsAcidic bileNF-κBNF-κB activationGamma-H2A histone family member XHypopharyngeal squamous cell carcinomaOncogenic profileNuclear factor kappa BPARP-1Squamous cell carcinomaB-cell lymphoma 2 expressionNF-κB transcriptional activityFactor kappa BDNA damageEnzyme-linked immunosorbent assayH2A histone family member XCell survivalDNA/RNA damageHypopharyngeal carcinogenesisReflux contentsAnti-apoptotic phenotypeCell carcinomaWidespread DNA damageBAY 11PARP-1 overexpressionPET/CT radiomics potentially improves progression-free survival (PFS) and overall survival (OS) prognostication beyond UICC TNM staging in oropharyngeal squamous cell carcinoma (OPSCC) patients
Haider S, Sharaf K, Zeevi T, Mahajan A, Forghani R, Judson B, Kann B, Burtness B, Reichel C, Baumeister P, Payabvash S. PET/CT radiomics potentially improves progression-free survival (PFS) and overall survival (OS) prognostication beyond UICC TNM staging in oropharyngeal squamous cell carcinoma (OPSCC) patients. Laryngo-Rhino-Otologie 2022, 101: s184-s184. DOI: 10.1055/s-0042-1746471.Peer-Reviewed Original Research