2000
Conservation of localization patterns of IP3 receptor type 1 in cerebellar Purkinje cells across vertebrate species
Koulen P, Janowitz T, Johnston L, Ehrlich B. Conservation of localization patterns of IP3 receptor type 1 in cerebellar Purkinje cells across vertebrate species. Journal Of Neuroscience Research 2000, 61: 493-499. PMID: 10956418, DOI: 10.1002/1097-4547(20000901)61:5<493::aid-jnr3>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsHigh expression levelsVertebrate speciesDifferent vertebrate speciesPhylogenetic developmentNumber of speciesExpression levelsType 1 proteinIP3 receptor type 1Distribution of inositolLocalization patternsMolecular levelPurkinje cellsFluorescence immunocytochemistryCellular levelSpeciesFunctional differencesPolyclonal antiserumAdult cerebellumCerebellar Purkinje cellsReceptor type 1CellsConservationIntracellular calciumOrganismsPurkinje cell dendritesRegulation of the Type III InsP3 Receptor by InsP3 and ATP
Hagar R, Ehrlich B. Regulation of the Type III InsP3 Receptor by InsP3 and ATP. Biophysical Journal 2000, 79: 271-278. PMID: 10866953, PMCID: PMC1300931, DOI: 10.1016/s0006-3495(00)76289-8.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAllosteric RegulationAnimalsBinding, CompetitiveCalcium ChannelsDose-Response Relationship, DrugEndoplasmic ReticulumInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsInsulinomaMicrosomesProtein IsoformsRatsReceptors, Cytoplasmic and NuclearSubstrate SpecificityTumor Cells, CulturedConceptsType IIIChannel activityIntracellular calciumMaximal channel activityATP concentrationProlonged stimulationDependent inhibitionAllosteric modulationInsP3 receptorEnhanced channel activityType IOpen probabilityOpen timeReceptorsHigh ATP concentrationsHigh levelsATPLow ATP concentrationsIsoformsActivity
1998
Type III InsP3 receptor channel stays open in the presence of increased calcium
Hagar R, Burgstahler A, Nathanson M, Ehrlich B. Type III InsP3 receptor channel stays open in the presence of increased calcium. Nature 1998, 396: 81-84. PMID: 9817204, PMCID: PMC2825878, DOI: 10.1038/23954.Peer-Reviewed Original Research
1994
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
Brillantes A, Ondrias K, Scott A, Kobrinsky E, Ondriašová E, Moschella M, Jayaraman T, Landers M, Ehrlich B, Marks A. Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell 1994, 77: 513-523. PMID: 7514503, DOI: 10.1016/0092-8674(94)90214-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaffeineCalciumCalcium ChannelsCarrier ProteinsCell LineCloning, MolecularGene ExpressionHeat-Shock ProteinsIon Channel GatingIsometric ContractionLipid BilayersMuscle ProteinsPolyenesRabbitsRatsRecombinant ProteinsRNA, MessengerRuthenium RedRyanodineRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumSirolimusTacrolimusTacrolimus Binding ProteinsConceptsCellular functionsFK506-binding proteinNatural cellular functionsRelease channel functionInsect cellsProline isomeraseIsomerase activityEndoplasmic reticulumChannel functionFKBP12Channel complexRyanodine receptorCytosolic receptorRelease channel complexRelease channelRapamycinProteinFunctional Ca2Open probabilityCaffeine activationIntracellular Ca2Mean open timeImmunosuppressant drugsCopurifiesReceptors
1980
Effects of lithium on blood-brain barrier transport of the neurotransmitter precursors choline, tyrosine and tryptophan
Ehrlich B, Diamond J, Braun L, Cornford E, Oldendorf W. Effects of lithium on blood-brain barrier transport of the neurotransmitter precursors choline, tyrosine and tryptophan. Brain Research 1980, 193: 604-607. PMID: 7388615, DOI: 10.1016/0006-8993(80)90198-5.Peer-Reviewed Original Research