2000
Reversible Block of the Calcium Release Channel/Ryanodine Receptor by Protamine, a Heparin Antidote
Koulen P, Ehrlich B. Reversible Block of the Calcium Release Channel/Ryanodine Receptor by Protamine, a Heparin Antidote. Molecular Biology Of The Cell 2000, 11: 2213-2219. PMID: 10888663, PMCID: PMC14914, DOI: 10.1091/mbc.11.7.2213.Peer-Reviewed Original ResearchConceptsCalcium release channelRyanodine receptorChannel activityIntracellular calcium releaseRelease channelRyanodine receptor activityReceptor type 1Application of protamineMechanism of actionChannel/ryanodine receptorCalcium release channel/ryanodine receptorRelease channel/ryanodine receptorBulk calcium concentrationAddition of heparinRyanodine receptor type 1Single-channel activityReceptor activityCalcium releaseType 1Muscle cellsCalcium concentrationSkeletal muscleHeparin antidoteReversible blockProtamine sulfate
1998
Characterization of the ryanodine receptor/channel of invertebrate muscle
Quinn K, Castellani L, Ondrias K, Ehrlich B. Characterization of the ryanodine receptor/channel of invertebrate muscle. American Journal Of Physiology 1998, 274: r494-r502. PMID: 9486309, DOI: 10.1152/ajpregu.1998.274.2.r494.Peer-Reviewed Original ResearchConceptsInvertebrate musclesRyanodine receptor/channelVertebrate skeletal muscleDiverse organismsCalcium release channel/ryanodine receptorRelease channel/ryanodine receptorChannel/ryanodine receptorSingle-channel conductanceReceptor/channelElectron microscopic analysisRyanodine receptorSkeletal muscleRelease channelCytoplasmic Ca2Single-channel currentsSpecific ryanodine bindingChannel conductanceSarcoplasmic reticulumRyRsRuthenium redInvertebratesCa2MammalianRyanodine bindingOrganisms
1997
Regulation of Intracellular Calcium Release Channel Function by Arachidonic Acid and Leukotriene B4
Striggow F, Ehrlich B. Regulation of Intracellular Calcium Release Channel Function by Arachidonic Acid and Leukotriene B4. Biochemical And Biophysical Research Communications 1997, 237: 413-418. PMID: 9268725, DOI: 10.1006/bbrc.1997.7152.Peer-Reviewed Original ResearchConceptsLeukotriene B4Arachidonic acidCalcium release channelNM leukotriene B4Intracellular calcium concentrationRelease channelIntracellular calcium release channelsTrisphosphate-gated channelsRelease channel functionCalcium concentrationRyanodine receptorChannel functionCell typesSpecific mobilizationB4RyRsAgonistsConcerted action
1996
Effects of Rapamycin on Ryanodine Receptor/Ca2+-Release Channels From Cardiac Muscle
Kaftan E, Marks A, Ehrlich B. Effects of Rapamycin on Ryanodine Receptor/Ca2+-Release Channels From Cardiac Muscle. Circulation Research 1996, 78: 990-997. PMID: 8635249, DOI: 10.1161/01.res.78.6.990.Peer-Reviewed Original ResearchConceptsRelease channelFK506-binding proteinCardiac muscleLong-term depressionEffect of rapamycinChannel functionProlyl isomerase activityRelease of Ca2Ryanodine receptor/Ca2Immunosuppressant drugsSkeletal muscle isoformCardiac RyRIsomerase activityRyanodine receptorRapamycinRyRsChannel familyImportant regulatory roleCis-trans peptidylOpen probabilitySubmicromolar concentrationsCell typesDrugsMuscleMuscle isoform
1994
The pharmacology of intracellular Ca2+-release channels
Ehrlich B, Kaftan E, Bezprozvannaya S, Bezprozvanny I. The pharmacology of intracellular Ca2+-release channels. Trends In Pharmacological Sciences 1994, 15: 145-149. PMID: 7754532, DOI: 10.1016/0165-6147(94)90074-4.Peer-Reviewed Original ResearchStabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
Brillantes A, Ondrias K, Scott A, Kobrinsky E, Ondriašová E, Moschella M, Jayaraman T, Landers M, Ehrlich B, Marks A. Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell 1994, 77: 513-523. PMID: 7514503, DOI: 10.1016/0092-8674(94)90214-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaffeineCalciumCalcium ChannelsCarrier ProteinsCell LineCloning, MolecularGene ExpressionHeat-Shock ProteinsIon Channel GatingIsometric ContractionLipid BilayersMuscle ProteinsPolyenesRabbitsRatsRecombinant ProteinsRNA, MessengerRuthenium RedRyanodineRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumSirolimusTacrolimusTacrolimus Binding ProteinsConceptsCellular functionsFK506-binding proteinNatural cellular functionsRelease channel functionInsect cellsProline isomeraseIsomerase activityEndoplasmic reticulumChannel functionFKBP12Channel complexRyanodine receptorCytosolic receptorRelease channel complexRelease channelRapamycinProteinFunctional Ca2Open probabilityCaffeine activationIntracellular Ca2Mean open timeImmunosuppressant drugsCopurifiesReceptors
1991
Comparison of calcium release from sarcoplasmic reticulum of slow and fast twitch muscles
Lee Y, Ondrias K, Duhl A, Ehrlich B, Kim D. Comparison of calcium release from sarcoplasmic reticulum of slow and fast twitch muscles. The Journal Of Membrane Biology 1991, 122: 155-163. PMID: 1716686, DOI: 10.1007/bf01872638.Peer-Reviewed Original ResearchConceptsFast sarcoplasmic reticulumFast-twitch muscleSarcoplasmic reticulumRelease channelSlow sarcoplasmic reticulumTwitch muscleFast musclesSR vesiclesTypes of muscleCalcium releaseMechanism of Ca2MuscleScatchard analysisRyanodine receptorFunctional assaysRuthenium redSingle Ca2Single-channel conductanceOpen probabilityMolecular weight proteinsCa2Closed timeHigh molecular weight proteinsFunctional differences
1990
Comparison of calcium release channels in reticular membranes from smooth muscle, skeletal muscle and cerebellum
Watras J, Adler P, Ondrias K, Ehrlich B. Comparison of calcium release channels in reticular membranes from smooth muscle, skeletal muscle and cerebellum. Journal Of Molecular And Cellular Cardiology 1990, 22: s9. DOI: 10.1016/0022-2828(90)91336-6.Peer-Reviewed Original Research