Bailey Holt-Gosselin
About
Research
Publications
2024
4.6 Examining Familial Risk of Depression and Family Conflict in the Prediction of Psychopathology in the ABCD Study
Basol E, Holt-Gosselin B, Joormann J, Gee D, Rodrigues K, Keding T. 4.6 Examining Familial Risk of Depression and Family Conflict in the Prediction of Psychopathology in the ABCD Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 63: s232. DOI: 10.1016/j.jaac.2024.08.251.Peer-Reviewed Original ResearchPersonalized brain circuit scores identify clinically distinct biotypes in depression and anxiety
Tozzi L, Zhang X, Pines A, Olmsted A, Zhai E, Anene E, Chesnut M, Holt-Gosselin B, Chang S, Stetz P, Ramirez C, Hack L, Korgaonkar M, Wintermark M, Gotlib I, Ma J, Williams L. Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety. Nature Medicine 2024, 30: 2076-2087. PMID: 38886626, PMCID: PMC11271415, DOI: 10.1038/s41591-024-03057-9.Peer-Reviewed Original ResearchBehavioral therapyFunctional magnetic resonance imaging protocolTask-free functional connectivityHeterogeneity of depressionBrain circuit dysfunctionResponse to pharmacotherapyTheoretical taxonomyAttentional circuitsNeurobiological dysfunctionBehavioral performanceCircuit dysfunctionCognitive tasksSubcortical regionsFunctional connectivityTask-freeAnxietyDepressionTheory-drivenPharmacotherapyStratification of patientsMagnetic resonance imaging protocolScoresPsychiatryDysfunctionClinical careFamilial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study
Holt-Gosselin B, Keding T, Rodrigues K, Rueter A, Hendrickson T, Perrone A, Byington N, Houghton A, Miranda-Dominguez O, Feczko E, Fair D, Joormann J, Gee D. Familial risk for depression moderates neural circuitry in healthy preadolescents to predict adolescent depression symptoms in the Adolescent Brain Cognitive Development (ABCD) Study. Developmental Cognitive Neuroscience 2024, 68: 101400. PMID: 38870601, PMCID: PMC11225685, DOI: 10.1016/j.dcn.2024.101400.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentAdolescent depressive symptomsDepressive symptomsFamilial riskFunctional connectivityResting-state FC patternsCognitive developmentFamily history of depressionAdolescent-onset depressionLow familial riskHistory of depressionElevated familial riskMixed-effects regression analysisNucleus accumbensStriatal FCLR youthHR youthSensory/somatomotor networkFC patternsNeural circuitryNeural markersDepression riskDepressionPreadolescentsLongitudinal study
2023
Neural Circuit Markers of Familial Risk for Depression Among Healthy Youths in the Adolescent Brain Cognitive Development Study
Holt-Gosselin B, Keding T, Poulin R, Brieant A, Rueter A, Hendrickson T, Perrone A, Byington N, Houghton A, Miranda-Dominguez O, Feczko E, Fair D, Joormann J, Gee D. Neural Circuit Markers of Familial Risk for Depression Among Healthy Youths in the Adolescent Brain Cognitive Development Study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 9: 185-195. PMID: 37182734, PMCID: PMC10640659, DOI: 10.1016/j.bpsc.2023.05.001.Peer-Reviewed Original ResearchFamilial riskHR youthLR youthHealthy youthWhole-brain seedEarly-onset depressionResting-state FCYears of ageBrain-based markersFunctional connectivity patternsHigh familial riskCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyMaternal riskLow familial riskMaternal historyFamily historyStriatal connectivityMaternal depressionDepression riskNucleus accumbensPsychiatric problemsNeural circuitsEarly detectionSmall sample sizeChildhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood
Ziobrowski H, Holt-Gosselin B, Petukhova M, King A, Lee S, House S, Beaudoin F, An X, Stevens J, Zeng D, Neylan T, Clifford G, Linnstaedt S, Germine L, Bollen K, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Kurz M, Swor R, Hudak L, Pascual J, Seamon M, Harris E, Pearson C, Merchant R, Domeier R, Rathlev N, O'Neil B, Sergot P, Sanchez L, Bruce S, Miller M, Pietrzak R, Joormann J, Barch D, Pizzagalli D, Harte S, Elliott J, Ressler K, McLean S, Koenen K, Kessler R. Childhood adversities and risk of posttraumatic stress disorder and major depression following a motor vehicle collision in adulthood. Epidemiology And Psychiatric Sciences 2023, 32: e1. PMID: 36624694, PMCID: PMC9879881, DOI: 10.1017/s2045796022000798.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAdverse posttraumatic neuropsychiatric sequelaeChildhood adversityEmotional abuseStress disorderEmotional neglectChronic posttraumatic stress disorderSelf-report criteriaPeritraumatic symptomsTraumatic eventsPTSD ChecklistSexual abusePhysical neglectMajor depressive episodeMotor vehicle collisionsPhysical abuseDSM-5CA measuresBullyingAbuseStrongest predictorAdversityTrauma studiesDichotomous measureExposure frequency
2022
Lack of Robust Associations Between Prepandemic Coping Strategies and Frontolimbic Circuitry With Depression and Anxiety Symptoms During the COVID-19 Pandemic: A Preregistered Longitudinal Study
Holt-Gosselin B, Cohodes E, McCauley S, Foster J, Odriozola P, Zacharek S, Kribakaran S, Haberman J, Hodges H, Gee D. Lack of Robust Associations Between Prepandemic Coping Strategies and Frontolimbic Circuitry With Depression and Anxiety Symptoms During the COVID-19 Pandemic: A Preregistered Longitudinal Study. Behavioral Neuroscience 2022, 136: 528-540. PMID: 36395014, PMCID: PMC9884515, DOI: 10.1037/bne0000534.Peer-Reviewed Original ResearchConceptsFrontolimbic circuitryAnxiety symptomsFunctional connectivityMental health outcomesCoping strategiesResting-state functional magnetic resonanceAdaptive coping strategiesLongitudinal studyFunctional magnetic resonanceMental health problemsACC functional connectivityAdaptive copingPreregistered hypothesesInternalizing symptomsNeurobehavioral factorsEmotional responsesPreregistered studyNeurobiological factorsOngoing stressorsElevated symptomsDepression symptomsHealth outcomesCopingCOVID-19 pandemicRobust associationAssociations Between Early-Life Stress Exposure and Internalizing Symptomatology During the COVID-19 Pandemic: Assessing the Role of Neurobehavioral Mediators
Foster JC, Cohodes EM, Brieant AE, McCauley S, Odriozola P, Zacharek SJ, Pierre JC, Hodges HR, Kribakaran S, Haberman JT, Holt-Gosselin B, Gee DG. Associations Between Early-Life Stress Exposure and Internalizing Symptomatology During the COVID-19 Pandemic: Assessing the Role of Neurobehavioral Mediators. Biological Psychiatry Global Open Science 2022, 3: 362-373. PMID: 35959474, PMCID: PMC9356644, DOI: 10.1016/j.bpsgos.2022.07.006.Peer-Reviewed Original ResearchEarly life stressImpact of ELSResting-state functional connectivity dataEffects of ELSLife stress exposureCOVID-19 pandemicPandemic-related stressSignificant direct associationFunctional connectivity dataInternalizing symptomatologyELS exposurePsychiatric illnessOngoing COVID-19 pandemicGeneral populationSample of adultsPsychological functioningFunctional connectivityStress exposureMental healthSymptomatologyNeurobehavioral factorsAssociationEmotion regulationCOVIDDirect associationIntrinsic Connectivity and Family Dynamics: Striatolimbic Markers of Risk and Resilience in Youth at Familial Risk for Mood Disorders
Fischer AS, Holt-Gosselin B, Hagan KE, Fleming SL, Nimarko AF, Gotlib IH, Singh MK. Intrinsic Connectivity and Family Dynamics: Striatolimbic Markers of Risk and Resilience in Youth at Familial Risk for Mood Disorders. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 855-866. PMID: 35272095, PMCID: PMC9452604, DOI: 10.1016/j.bpsc.2022.02.009.Peer-Reviewed Original ResearchConceptsLow-risk youthMood disordersFunctional connectivityFamilial riskFC differencesFC relativeRisk statusMajor depressive disorderHigh familial riskDepressive disorderMore effective interventionsBipolar disorderNovel interventionsIntrinsic connectivityEffective interventionsFrontal gyrusDisordersRiskGyrusPsychopathologyFamily rigidityNeural underpinningsInterventionNeural signaturesFamily dynamics
2021
Greater baseline connectivity of the salience and negative affect circuits are associated with natural improvements in anxiety over time in untreated participants
Holt-Gosselin B, Keller AS, Chesnut M, Ling R, Grisanzio KA, Williams LM. Greater baseline connectivity of the salience and negative affect circuits are associated with natural improvements in anxiety over time in untreated participants. Journal Of Affective Disorders 2021, 295: 366-376. PMID: 34492429, DOI: 10.1016/j.jad.2021.08.039.Peer-Reviewed Original ResearchConceptsAnxiety symptom improvementNegative affect circuitSymptoms of anxietyCognitive controlSymptom improvementSad facesLifestyle activitiesPositive affectBehavioral therapyCircuit connectivityBaseline connectivityDefault modeRight insulaPsychosocial functionSocial interactionAnxiety improvementActivity engagementDepression symptomsAnxietySalienceNeural circuit functionNatural improvementUntreated participantsCausal inferenceLimited researchMapping Neural Circuit Biotypes to Symptoms and Behavioral Dimensions of Depression and Anxiety
Goldstein-Piekarski AN, Ball TM, Samara Z, Staveland BR, Keller AS, Fleming SL, Grisanzio KA, Holt-Gosselin B, Stetz P, Ma J, Williams LM. Mapping Neural Circuit Biotypes to Symptoms and Behavioral Dimensions of Depression and Anxiety. Biological Psychiatry 2021, 91: 561-571. PMID: 34482948, PMCID: PMC9511971, DOI: 10.1016/j.biopsych.2021.06.024.Peer-Reviewed Original ResearchConceptsCognitive controlAnxious avoidanceTransdiagnostic symptomsCognitive functionAnxiety disordersAffective circuitsBehavioral dimensionsLoss of pleasurePoorer daily functionBrain circuitsEmotional functionAnxietyNeural circuitsIndependent samplesHealthy reference sampleHuman neural circuitsTreatment targetsDepressionDaily functionIndividual patient levelCircuit assessmentCircuit definitionIntervention treatmentDysfunction scoreClinical scores