Genetic Associations with Gestational Duration and Spontaneous Preterm Birth
Zhang G, Feenstra B, Bacelis J, Liu X, Muglia LM, Juodakis J, Miller DE, Litterman N, Jiang PP, Russell L, Hinds DA, Hu Y, Weirauch MT, Chen X, Chavan AR, Wagner GP, Pavličev M, Nnamani MC, Maziarz J, Karjalainen MK, Rämet M, Sengpiel V, Geller D, Boyd HA, Palotie A, Momany A, Bedell B, Ryckman KK, Huusko JM, Forney CR, Kottyan LC, Hallman M, Teramo K, Nohr EA, Davey-Smith G, Melbye M, Jacobsson B, Muglia LJ. Genetic Associations with Gestational Duration and Spontaneous Preterm Birth. New England Journal Of Medicine 2017, 377: 1156-1167. PMID: 28877031, PMCID: PMC5561422, DOI: 10.1056/nejmoa1612665.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesDatasets as TopicFemaleGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGestational AgeHumansPeptide Elongation FactorsPhenotypePolymorphism, Single NucleotidePregnancyPremature BirthRas ProteinsReceptor, Angiotensin, Type 2Regression AnalysisTrans-ActivatorsWnt4 ProteinConceptsGestational durationPreterm birthDiscovery setSpontaneous preterm birthDuration of gestationMother-infant dyadsGenomewide association studiesGenetic associationVascular controlMaternal nutritionSignificant genomewide associationEstrogen receptorPossible genetic associationDichotomous outcomesUterine developmentGenetic factorsMechanistic involvementReplication data setsAssociation studiesBirthSuggestive significanceGenomewide significanceAGTR2Replication setAssociation