1990
Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification
Summers J, Smith P, Horwich A. Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification. Journal Of Virology 1990, 64: 2819-2824. PMID: 2335817, PMCID: PMC249463, DOI: 10.1128/jvi.64.6.2819-2824.1990.Peer-Reviewed Original ResearchConceptsCccDNA synthesisEnvelope proteinVirus-mediated cell deathHepadnavirus envelope proteinsCircular DNA amplificationViral DNA synthesisWild-type virusWild typeViral envelope proteinsCell deathCircular DNAPrimary duck hepatocytesDNA synthesisProteinDNA amplificationPersistent infectionDuck hepatocytes
1985
Expression of amplified DNA sequences for ornithine transcarbamylase in HeLa cells: arginine residues may be required for mitochondrial import of enzyme precursor.
Horwich A, Fenton W, Firgaira F, Fox J, Kolansky D, Mellman I, Rosenberg L. Expression of amplified DNA sequences for ornithine transcarbamylase in HeLa cells: arginine residues may be required for mitochondrial import of enzyme precursor. Journal Of Cell Biology 1985, 100: 1515-1521. PMID: 3988798, PMCID: PMC2113848, DOI: 10.1083/jcb.100.5.1515.Peer-Reviewed Original ResearchConceptsMitochondrial importOTC precursorsHeLa cellsOrnithine transcarbamylaseArginine residuesMouse dihydrofolate reductaseNH2-terminal leader sequenceRate of importArginine analog canavanineViral regulatory elementsImmunoprecipitation of extractsMitochondrial localizationCDNA sequenceRegulatory elementsLeader sequenceDNA sequencesEnzyme precursorsMitochondrial enzymesCell extractsDihydrofolate reductaseEnzymatic activityBlot analysisNormal precursorsResiduesSubunits