Featured Publications
Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology
Patterson AR, Endale M, Lampe K, Aksoylar HI, Flagg A, Woodgett JR, Hildeman D, Jordan MB, Singh H, Kucuk Z, Bleesing J, Hoebe K. Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology. Nature Communications 2018, 9: 430. PMID: 29382851, PMCID: PMC5789891, DOI: 10.1038/s41467-018-02897-7.Peer-Reviewed Original ResearchConceptsCell proliferationGlycogen synthase kinase-3βC-myc inductionT cell proliferationSynthase kinase-3βNuclear importSer389 phosphorylationGSK3 inhibitorsCell homeostasisT cellsFunction mutationsKinase-3βGenetic targetingDNA damageProtein 5Nuclear translocationT cell homeostasisGSK3β activityT cell activationImportant checkpointGSK3βGimap5Pharmacological inhibitionGIMAP5 deficiencyLymphocyte survival
2004
Angular velocity: a new method to improve prediction of ventricular fibrillation duration
Sherman LD, Flagg A, Callaway CW, Menegazzi JJ, Hsieh M. Angular velocity: a new method to improve prediction of ventricular fibrillation duration. Resuscitation 2004, 60: 79-90. PMID: 15002486, DOI: 10.1016/j.resuscitation.2003.07.001.Peer-Reviewed Original ResearchConceptsVentricular fibrillationDuration of VFTreatment of VFMin durationVentricular fibrillation durationDifferent clinical phasesFibrillation durationAppropriate medicationLeading causeSudden deathChest compressionsPrimary modalityElectrical defibrillationVF durationClinical settingClinical interventionsClinical phaseEstimates of durationVF waveformDurationS recordingsTreatmentS intervals