Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology
Patterson AR, Endale M, Lampe K, Aksoylar HI, Flagg A, Woodgett JR, Hildeman D, Jordan MB, Singh H, Kucuk Z, Bleesing J, Hoebe K. Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology. Nature Communications 2018, 9: 430. PMID: 29382851, PMCID: PMC5789891, DOI: 10.1038/s41467-018-02897-7.Peer-Reviewed Original ResearchConceptsCell proliferationGlycogen synthase kinase-3βC-myc inductionT cell proliferationSynthase kinase-3βNuclear importSer389 phosphorylationGSK3 inhibitorsCell homeostasisT cellsFunction mutationsKinase-3βGenetic targetingDNA damageProtein 5Nuclear translocationT cell homeostasisGSK3β activityT cell activationImportant checkpointGSK3βGimap5Pharmacological inhibitionGIMAP5 deficiencyLymphocyte survivalLymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia
Mahat U, Garg B, Yang CY, Mehta H, Hanna R, Rogers HJ, Flagg A, Ivanov AI, Corey SJ. Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia. Blood Advances 2022, 6: 2581-2594. PMID: 34991157, PMCID: PMC9043934, DOI: 10.1182/bloodadvances.2021006398.Peer-Reviewed Original ResearchMeSH KeywordsActinsCell ProliferationChildHeLa CellsHumansLymphocytesMembrane GlycoproteinsMicrofilament ProteinsMutationNeutropeniaConceptsLymphocyte cytosolic protein 1Impaired cell motilityDiffuse intracellular localizationUnfolded protein responseCytosolic protein 1Level of genesCell cycle arrestActin regulationG2/M phaseNew genesActin cytoskeletonActin dynamicsCell motilityProtein responseSubcellular fractionationMutant formsF-actinIntracellular localizationWhole-exome sequencingCycle arrestHeLa cellsMissense mutationsHeterozygous missense mutationM phaseLCP1