2000
Novel compounds, ‘1,3-selenazine derivatives’ as specific inhibitors of eukaryotic elongation factor-2 kinase
Cho S, Koketsu M, Ishihara H, Matsushita M, Nairn A, Fukazawa H, Uehara Y. Novel compounds, ‘1,3-selenazine derivatives’ as specific inhibitors of eukaryotic elongation factor-2 kinase. Biochimica Et Biophysica Acta 2000, 1475: 207-215. PMID: 10913818, DOI: 10.1016/s0304-4165(00)00061-1.Peer-Reviewed Original ResearchConceptsV-src-transformed NIH3T3 cellsEukaryotic elongation factor 2 kinaseProtein kinase AElongation factor 2 kinaseProtein kinase CProtein tyrosine kinasesEEF-2KProtein kinaseEEF-2K inhibitorNIH3T3 cellsCalmodulin-dependent protein kinaseV-Src kinaseMultiple protein kinasesCalmodulin-dependent protein kinase IIProtein levelsK inhibitorsProtein kinase IIEEF-2K.Kinase AKinase IITyrosine kinaseKinase CKinaseTs-4Specific inhibitor
1988
Protein kinases 1988: a current perspective
Blackshear P, Nairn A, Kuo J. Protein kinases 1988: a current perspective. The FASEB Journal 1988, 2: 2957-2969. PMID: 2972578, DOI: 10.1096/fasebj.2.14.2972578.Peer-Reviewed Original ResearchConceptsProtein tyrosine kinasesProtein kinaseIntrinsic protein tyrosine kinase activityProtein serine/threonine kinaseKinase activityTyrosine kinaseCalcium/calmodulin-dependent protein kinaseSerine/threonine kinaseCalmodulin-dependent protein kinaseProtein tyrosine kinase activityPhosphatidylinositol kinase activityNew enzyme speciesTyrosine kinase activityMyosin light chain kinaseCalmodulin kinase IIPseudosubstrate prototopeKinase IIIThreonine kinaseSignal transductionLight chain kinaseConstitutive inhibitorGrowth factor receptorKinase autophosphorylationSubstrate specificityCalcium-calmodulin kinase II
1986
Protein phosphorylation in cultured endothelial cells
Mackie K, Lai Y, Nairn A, Greengard P, Pitt B, Lazo J. Protein phosphorylation in cultured endothelial cells. Journal Of Cellular Physiology 1986, 128: 367-374. PMID: 3745280, DOI: 10.1002/jcp.1041280304.Peer-Reviewed Original ResearchConceptsCalcium/calmodulin-dependent protein kinaseCalmodulin-dependent protein kinaseCyclic AMP-dependent protein kinaseAMP-dependent protein kinaseProtein kinase activityProtein kinaseKinase activityCyclic GMP-dependent protein kinase activityRespective substrate proteinsProtein phosphorylation systemsProtein kinase CSubstrate proteinsProtein phosphorylationPhosphorylation systemEndothelial cellsNumerous substratesTyrosine kinaseKinase CPulmonary artery endothelial cellsKinaseCultured endothelial cellsArtery endothelial cellsSimilar culture conditionsCulture conditionsCells