2008
Angiographic Surrogate End Points in Drug-Eluting Stent Trials A Systematic Evaluation Based on Individual Patient Data From 11 Randomized, Controlled Trials
Pocock SJ, Lansky AJ, Mehran R, Popma JJ, Fahy MP, Na Y, Dangas G, Moses JW, Pucelikova T, Kandzari DE, Ellis SG, Leon MB, Stone GW. Angiographic Surrogate End Points in Drug-Eluting Stent Trials A Systematic Evaluation Based on Individual Patient Data From 11 Randomized, Controlled Trials. Journal Of The American College Of Cardiology 2008, 51: 23-32. PMID: 18174032, DOI: 10.1016/j.jacc.2007.07.084.Peer-Reviewed Original ResearchConceptsDrug-eluting stentsBare metal stentsAngiographic measuresTLR riskEnd pointDifferent drug-eluting stentsPrimary end pointRisk of TLRFollow-up angiographyLower revascularization ratesSurrogate end pointsIndividual patient dataSuitable surrogate markerDES trialsRevascularization ratesTLR rateClinical restenosisControlled TrialsFuture trialsStent implantationStent trialsSurrogate marker
2007
Clinical End Points in Coronary Stent Trials
Cutlip DE, Windecker S, Mehran R, Boam A, Cohen DJ, van Es GA, Gabriel Steg P, Morel M, Mauri L, Vranckx P, McFadden E, Lansky A, Hamon M, Krucoff MW, Serruys PW. Clinical End Points in Coronary Stent Trials. Circulation 2007, 115: 2344-2351. PMID: 17470709, DOI: 10.1161/circulationaha.106.685313.Peer-Reviewed Original ResearchConceptsEnd point definitionsAcademic Research ConsortiumClinical end pointsEnd pointDrug AdministrationConsensus criteriaEffectiveness end pointClinical trial programKey pathophysiological mechanismMost clinical trialsCoronary stent trialsClinical trial purposesEvaluation of safetyTiming of assessmentResearch ConsortiumAssessment of deathStent thrombosisPathophysiological mechanismsAcademic research organizationsStent trialsMyocardial infarctionClinical trialsConsensus recommendationsTrial programPoint definition
2003
Feasibility and efficacy of tandem positioning on angiographic and clinical outcomes in the Intimal Hyperplasia Inhibition With Beta In-Stent Trial
Shirai K, Lansky AJ, Mintz GS, Costantini CO, Cristea E, Fahy M, Vandertie L, Yeung A, Raizner AE, Waksman R, Leon MB. Feasibility and efficacy of tandem positioning on angiographic and clinical outcomes in the Intimal Hyperplasia Inhibition With Beta In-Stent Trial. The American Journal Of Cardiology 2003, 91: 1113-1115. PMID: 12714158, DOI: 10.1016/s0002-9149(03)00160-7.Peer-Reviewed Original Research