2013
Non-Fibroatheroma Lesion Phenotype and Long-Term Clinical Outcomes A Substudy Analysis From the PROSPECT Study
Dohi T, Mintz GS, McPherson JA, de Bruyne B, Farhat NZ, Lansky AJ, Mehran R, Weisz G, Xu K, Stone GW, Maehara A. Non-Fibroatheroma Lesion Phenotype and Long-Term Clinical Outcomes A Substudy Analysis From the PROSPECT Study. JACC Cardiovascular Imaging 2013, 6: 908-916. PMID: 23850249, DOI: 10.1016/j.jcmg.2013.04.008.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAge FactorsAgedAngina, UnstableChi-Square DistributionCoronary VesselsFemaleFibrosisHospitalizationHumansKaplan-Meier EstimateMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionNecrosisPercutaneous Coronary InterventionPhenotypePlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeUltrasonography, InterventionalVascular CalcificationConceptsMajor adverse cardiac eventsAcute coronary syndromeNonculprit lesionsClinical outcomesLong-term clinical outcomesVirtual histology intravascular ultrasoundPROSPECT studyCox proportional hazards modelAdverse cardiac eventsIntermediate-term prognosisSuccessful percutaneous interventionOverall plaque burdenLesion phenotypeFA lesionsProportional hazards modelSubstudy analysisCoronary syndromeCulprit lesionCardiac eventsPlaque burdenClinical eventsVH-IVUSPercutaneous interventionClinical impactHazards model
2011
Paclitaxel-Eluting Stents Compared With Bare Metal Stents in Diabetic Patients With Acute Myocardial Infarction
Witzenbichler B, Wöhrle J, Guagliumi G, Peruga JZ, Brodie BR, Dudek D, Kornowski R, Hartmann F, Hood KL, Parise H, Lansky AJ, Nikolsky E, Mehran R, Stone GW. Paclitaxel-Eluting Stents Compared With Bare Metal Stents in Diabetic Patients With Acute Myocardial Infarction. Circulation Cardiovascular Interventions 2011, 4: 130-138. PMID: 21364152, DOI: 10.1161/circinterventions.110.960245.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPaclitaxel-eluting stentsTarget lesion revascularizationBare metal stentsHORIZONS-AMI trialDiabetic patientsDiabetes mellitusStent thrombosisMyocardial infarctionPercutaneous interventionIschemia-driven target lesion revascularizationMetal stentsAcute Myocardial Infarction trialHigh-risk diabetic patientsMyocardial Infarction trialPrimary percutaneous interventionInsulin-treated diabetesAcute myocardial infarctionAngiographic late lossComparable safety outcomesBinary restenosisHarmonizing OutcomesLesion revascularizationNondiabetic patientsAngiographic restenosis
2010
Impact of Bivalirudin Therapy in High-Risk Patients With Acute Myocardial Infarction 1-Year Results From the HORIZONS-AMI (Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction) Trial
Parodi G, Antoniucci D, Nikolsky E, Witzenbichler B, Guagliumi G, Peruga JZ, Stuckey T, Dudek D, Kornowski R, Hartmann F, Lansky AJ, Mehran R, Stone GW. Impact of Bivalirudin Therapy in High-Risk Patients With Acute Myocardial Infarction 1-Year Results From the HORIZONS-AMI (Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction) Trial. JACC Cardiovascular Interventions 2010, 3: 796-802. PMID: 20723849, DOI: 10.1016/j.jcin.2010.05.009.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAgedAngioplasty, Balloon, CoronaryAntibodies, MonoclonalAntithrombinsChi-Square DistributionEptifibatideEuropeFemaleFibrinolytic AgentsHemorrhageHeparinHirudinsHumansImmunoglobulin Fab FragmentsIsraelKaplan-Meier EstimateMaleMiddle AgedMyocardial InfarctionPatient SelectionPeptide FragmentsPeptidesPlatelet Aggregation InhibitorsProspective StudiesRecombinant ProteinsRisk AssessmentRisk FactorsSecondary PreventionStentsTime FactorsTreatment OutcomeUnited StatesConceptsGlycoprotein IIb/IIIa inhibitorsHORIZONS-AMI trialHigh-risk patientsAcute myocardial infarctionRecurrent myocardial infarctionUnfractionated heparinMyocardial infarctionHigh riskPrimary percutaneous coronary interventionIIb/IIIa inhibitorsBaseline patient riskCADILLAC risk scoreIntermediate-risk groupPrimary percutaneous interventionPercutaneous coronary interventionHigh-risk groupLow-risk groupBivalirudin therapyMajor bleedingTrial patientsCoronary interventionIntermediate riskClinical variablesPercutaneous interventionPatient risk
2009
Intravascular Ultrasound Comparison of the Retrograde Versus Antegrade Approach to Percutaneous Intervention for Chronic Total Coronary Occlusions
Tsujita K, Maehara A, Mintz GS, Kubo T, Doi H, Lansky AJ, Stone GW, Moses JW, Leon MB, Ochiai M. Intravascular Ultrasound Comparison of the Retrograde Versus Antegrade Approach to Percutaneous Intervention for Chronic Total Coronary Occlusions. JACC Cardiovascular Interventions 2009, 2: 846-854. PMID: 19778773, DOI: 10.1016/j.jcin.2009.06.012.Peer-Reviewed Original ResearchConceptsRetrograde approachRetro groupAntegrade approachMyocardial Infarction flow grade 3Chronic total occlusion techniqueChronic total coronary occlusionsIntravascular Ultrasound ComparisonTotal coronary occlusionMinimum stent areaAngiographic extravasationRCA CTOsIntravascular ultrasound imagingCoronary perforationCTO lengthCTO lesionsCoronary occlusionCTO interventionGuidewire crossingPercutaneous interventionUltrasound comparisonCTO segmentGrade 3Stent areaOcclusion techniqueIntravascular ultrasound
2007
Six-Month Clinical and Angiographic Results of a Dedicated Drug-Eluting Stent for the Treatment of Coronary Bifurcation Narrowings
Grube E, Buellesfeld L, Neumann FJ, Verheye S, Abizaid A, McClean D, Mueller R, Lansky A, Mehran R, Costa R, Gerckens U, Trauthen B, Fitzgerald PJ. Six-Month Clinical and Angiographic Results of a Dedicated Drug-Eluting Stent for the Treatment of Coronary Bifurcation Narrowings. The American Journal Of Cardiology 2007, 99: 1691-1697. PMID: 17560877, DOI: 10.1016/j.amjcard.2007.01.043.Peer-Reviewed Original ResearchConceptsCoronary bifurcation lesionsBifurcation lesionsDe novo coronary bifurcation lesionsProspective multicenter single-arm studyBiolimus A9-eluting stentMulticenter single-arm studyResult of restenosisTarget lesion revascularizationClinical complication rateSingle-arm studyStent late lossSide branchesDrug-eluting stentsLate stent thrombosisBalloon angioplasty treatmentLesion revascularizationNonbifurcation lesionsAntiplatelet therapyComplication rateAngiographic resultsStent thrombosisBalloon angioplastyPercutaneous interventionAngioplasty treatmentAXXESS stent
2004
869-2 Impact of intravenous beta-blockade during primary percutaneous intervention on convalescent left ventricular function
Halkin A, Grines C, Cox D, Garcia E, Mehran R, Tcheng J, Griffin J, Guagliumi G, Brodie B, Turco M, Rutherford B, Aymong E, Lansky A, Stone G. 869-2 Impact of intravenous beta-blockade during primary percutaneous intervention on convalescent left ventricular function. Journal Of The American College Of Cardiology 2004, 43: a303-a304. DOI: 10.1016/s0735-1097(04)91284-3.Peer-Reviewed Original ResearchPrimary percutaneous interventionLeft ventricular functionVentricular functionPercutaneous interventionRelation between late patency of the infarct-related artery, left ventricular function, and clinical outcomes after primary percutaneous intervention for acute myocardial infarction (CADILLAC trial)
Halkin A, Aymong E, Cox DA, Mehran R, Lansky AJ, Fahy M, Weisz G, Garcia E, Tcheng JE, Grines CL, Stone GW. Relation between late patency of the infarct-related artery, left ventricular function, and clinical outcomes after primary percutaneous intervention for acute myocardial infarction (CADILLAC trial). The American Journal Of Cardiology 2004, 93: 349-353. PMID: 14759389, DOI: 10.1016/j.amjcard.2003.10.019.Peer-Reviewed Original ResearchConceptsInfarct-related arteryPercutaneous coronary interventionAcute myocardial infarctionInfarct arteryCoronary interventionVentricular functionClinical outcomesMyocardial infarctionMyocardial Infarction trial (TIMI) grade 3 flowPrimary percutaneous coronary interventionLeft ventricular ejection fractionDegree of restenosisGrade 3 flowPrimary percutaneous interventionEvent-free survivalVentricular ejection fractionLeft ventricular functionSustained patencyRoutine followEjection fractionIndependent predictorsLate patencyPercutaneous interventionSerial measuresArtery
2003
Prospective, randomized evaluation of thrombectomy prior to percutaneous intervention in diseased saphenous vein grafts and thrombus-containing coronary arteries
Stone GW, Cox DA, Babb J, Nukta D, Bilodeau L, Cannon L, Stuckey TD, Hermiller J, Cohen EA, Low R, Bailey SR, Lansky AJ, Kuntz RE, Investigators F. Prospective, randomized evaluation of thrombectomy prior to percutaneous intervention in diseased saphenous vein grafts and thrombus-containing coronary arteries. Journal Of The American College Of Cardiology 2003, 42: 2007-2013. PMID: 14662267, DOI: 10.1016/j.jacc.2003.10.001.Peer-Reviewed Original ResearchConceptsDiseased saphenous vein graftsSaphenous vein graftsNative coronary arteriesPeri-procedural myocardial infarctionEvent-free survivalCoronary arteryMyocardial infarctionControl patientsStent implantationRoutine thrombectomyVein graftsSize patientsLate event-free survivalMajor adverse cardiac eventsPeri-procedural myonecrosisAdverse cardiac eventsHigh-risk patientsPercutaneous coronary interventionLarge myocardial infarctionSafety of interventionsPrior thrombectomyCardiac eventsCoronary interventionPercutaneous interventionLate outcomesSafety and efficacy of a novel device for treatment of thrombotic and atherosclerotic lesions in native coronary arteries and saphenous vein grafts: Results from the multicenter X‐sizer for treatment of thrombus and atherosclerosis in coronary applications trial (X‐TRACT) study
Stone GW, Cox DA, Low R, Cates CU, Satler L, Bailey SR, Kuntz RE, Lansky AJ. Safety and efficacy of a novel device for treatment of thrombotic and atherosclerotic lesions in native coronary arteries and saphenous vein grafts: Results from the multicenter X‐sizer for treatment of thrombus and atherosclerosis in coronary applications trial (X‐TRACT) study. Catheterization And Cardiovascular Interventions 2003, 58: 419-427. PMID: 12652487, DOI: 10.1002/ccd.10511.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAtherectomy, CoronaryChi-Square DistributionCoronary AngiographyCoronary Artery DiseaseCoronary ThrombosisEquipment DesignEquipment SafetyFemaleFollow-Up StudiesGraft Occlusion, VascularHumansMaleMiddle AgedProbabilityRisk AssessmentSaphenous VeinStatistics, NonparametricStentsThrombectomyTreatment OutcomeConceptsSaphenous vein graftsNative coronary arteriesVein graftsX-SizerThrombotic lesionsCoronary arteryNon-Q-wave MIDistal branch occlusionTIMI 3 flowSide branch occlusionTreatment of thrombusDistal thromboemboliPeriprocedural MITIMI 0Adverse eventsThromboembolic complicationsConsecutive patientsAntegrade flowBranch occlusionPercutaneous interventionHistorical controlsAtherosclerotic lesionsTrial studyU.S. CentersLesionsPredictors and sequalae of subacute thrombosis after percutaneous intervention in acute myocardial infarction: The CADILLAC trial
Aymong E, Grines C, Cox D, Garcia E, Tcheng J, Griffin J, Guagliumi G, Stuckey T, Turco M, Carroll J, Rutherford B, Lansky A, Mehran R, Stone G. Predictors and sequalae of subacute thrombosis after percutaneous intervention in acute myocardial infarction: The CADILLAC trial. Journal Of The American College Of Cardiology 2003, 41: 393. DOI: 10.1016/s0735-1097(03)81130-0.Peer-Reviewed Original ResearchAcute myocardial infarctionCADILLAC trialMyocardial infarctionPercutaneous interventionThrombosisInfarctionSequalaeImpact of gender on the incidence and outcome of contrast-induced nephropathy after percutaneous coronary intervention.
Iakovou I, Dangas G, Mehran R, Lansky AJ, Ashby DT, Fahy M, Mintz GS, Kent KM, Pichard AD, Satler LF, Stone GW, Leon MB. Impact of gender on the incidence and outcome of contrast-induced nephropathy after percutaneous coronary intervention. Journal Of Invasive Cardiology 2003, 15: 18-22. PMID: 12499523.Peer-Reviewed Original ResearchConceptsContrast-induced nephropathyChronic renal failureOne-year mortalityIndependent predictorsPercutaneous interventionDiabetes mellitusClinical outcomesFemale genderMultivariate analysisOne-year clinical eventsNYHA IV classSevere heart failurePercutaneous coronary interventionImpact of genderCoronary interventionRenal failureHeart failureMale patientsCIN developmentClinical eventsPatientsMortalityMellitusNephropathySignificant gender differences
2002
Long-Term Outcome of Patients Treated With Repeat Percutaneous Coronary Intervention After Failure of γ-Brachytherapy for the Treatment of In-Stent Restenosis
Prpic R, Teirstein PS, Reilly JP, Moses JW, Tripuraneni P, Lansky AJ, Giorgianni JA, Jani S, Wong SC, Fish RD, Ellis S, Holmes DR, Kereiakas D, Kuntz RE, Leon MB. Long-Term Outcome of Patients Treated With Repeat Percutaneous Coronary Intervention After Failure of γ-Brachytherapy for the Treatment of In-Stent Restenosis. Circulation 2002, 106: 2340-2345. PMID: 12403664, DOI: 10.1161/01.cir.0000036366.62288.74.Peer-Reviewed Original ResearchConceptsTarget lesion revascularizationIndex treatmentIntracoronary brachytherapyPercutaneous interventionStent restenosisAcceptable long-term resultsMajor adverse event rateRepeat percutaneous coronary interventionRepeat target vessel revascularizationSubsequent target lesion revascularizationTarget vessel revascularizationAcute procedural successAdverse event ratesPercutaneous coronary interventionIntracoronary radiation therapyLong-term outcomesLong-term resultsIn-Stent RestenosisLesion revascularizationPlacebo groupCoronary interventionFailure patientsProcedural successAngioplasty/Term outcomes
2001
Differential Impact on Survival of Electrocardiographic Q-Wave Versus Enzymatic Myocardial Infarction After Percutaneous Intervention
Stone G, Mehran R, Dangas G, Lansky A, Kornowski R, Leon M. Differential Impact on Survival of Electrocardiographic Q-Wave Versus Enzymatic Myocardial Infarction After Percutaneous Intervention. Circulation 2001, 104: 642-647. PMID: 11489768, DOI: 10.1161/hc3101.093902.Peer-Reviewed Original ResearchConceptsQ-wave myocardial infarctionMyocardial infarctionPercutaneous interventionCPK-MB elevationNon-Q-wave myocardial infarctionElective percutaneous interventionIndependent research nurseSerial creatine phosphokinasePeriprocedural myocardial infarctionTertiary referral centerRelative prognostic importanceNew Q wavesCPK-MB levelsPowerful independent determinantCPK-MB releaseEnzymatic elevationPeriprocedural infarctionReferral centerConsecutive patientsReferral populationResearch nursesIndependent determinantsPrognostic importanceStent useQ waves
1999
Glycoprotein IIb/IIIa Receptor Inhibitors During Primary Angioplasty for Acute Myocardial Infarction.
Gruberg L, Lansky A, Dangas G, Stone G. Glycoprotein IIb/IIIa Receptor Inhibitors During Primary Angioplasty for Acute Myocardial Infarction. Current Interventional Cardiology Reports 1999, 1: 359-367. PMID: 11096642.Peer-Reviewed Original ResearchAcute myocardial infarctionMyocardial infarctionGlycoprotein IIb/IIIa receptor inhibitorsIIb/IIIa receptor inhibitorsPlatelet glycoprotein IIb/IIIa receptorGlycoprotein IIb/IIIa receptor antagonistsGlycoprotein IIb/IIIa receptorIIb/IIIa receptor antagonistsTreatment of AMIIIb/IIIa receptorPrimary mechanical reperfusionAcute coronary syndromeFinal common pathwayIntravenous abciximabMechanical reperfusionCoronary syndromePrimary angioplastyCoronary thrombosisPharmacologic interventionsPercutaneous interventionReceptor antagonistLong-term benefitsPharmacologic agentsReceptor inhibitorsIIIa receptorPreintervention Arterial Remodeling as an Independent Predictor of Target-Lesion Revascularization After Nonstent Coronary Intervention
Dangas G, Mintz G, Mehran R, Lansky A, Kornowski R, Pichard A, Satler L, Kent K, Stone G, Leon M. Preintervention Arterial Remodeling as an Independent Predictor of Target-Lesion Revascularization After Nonstent Coronary Intervention. Circulation 1999, 99: 3149-3154. PMID: 10377078, DOI: 10.1161/01.cir.99.24.3149.Peer-Reviewed Original ResearchConceptsIndependent predictorsArterial remodelingTarget lesion revascularization rateInsulin-dependent diabetic patientsLong-term clinical outcomesQ-wave myocardial infarctionMultivariable logistic regression analysisTarget lesion revascularizationShort-term complicationsIntravascular ultrasound studyLong-term outcomesFinal lumen areaLogistic regression analysisIntermediate remodelingAngiographic characteristicsAngiographic successRevascularization ratesCoronary interventionClinical outcomesDiabetic patientsPlaque burdenPositive remodelingMyocardial infarctionNegative remodelingPercutaneous intervention