2021
Wall shear stress estimated by 3D-QCA can predict cardiovascular events in lesions with borderline negative fractional flow reserve
Tufaro V, Safi H, Torii R, Koo BK, Kitslaar P, Ramasamy A, Mathur A, Jones DA, Bajaj R, Erdoğan E, Lansky A, Zhang J, Konstantinou K, Little CD, Rakhit R, Karamasis GV, Baumbach A, Bourantas CV. Wall shear stress estimated by 3D-QCA can predict cardiovascular events in lesions with borderline negative fractional flow reserve. Atherosclerosis 2021, 322: 24-30. PMID: 33706080, DOI: 10.1016/j.atherosclerosis.2021.02.018.Peer-Reviewed Original ResearchConceptsNegative fractional flow reserveCardiovascular eventsFractional flow reservePrimary endpointFlow reserveSmaller minimum lumen areaAdverse cardiovascular eventsRetrospective cohort studyTarget lesion revascularizationOnly independent predictorMinimum lumen areaQCA variablesAngiographic characteristicsLesion revascularizationCulprit lesionHighest maximum wall shear stressCohort studyCardiac deathIndependent predictorsComplete followMultivariable analysisMyocardial infarctionTarget lesionsArea stenosisNegative FFR
2020
Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events
Bourantas CV, Zanchin T, Torii R, Serruys PW, Karagiannis A, Ramasamy A, Safi H, Coskun AU, Koning G, Onuma Y, Zanchin C, Krams R, Mathur A, Baumbach A, Mintz G, Windecker S, Lansky A, Maehara A, Stone PH, Raber L, Stone GW. Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events. JACC Cardiovascular Imaging 2020, 13: 2206-2219. PMID: 32417338, DOI: 10.1016/j.jcmg.2020.02.028.Peer-Reviewed Original ResearchConceptsHigh endothelial shear stressEndothelial shear stressLipid-rich plaquesPlaque burdenCardiovascular eventsPlaque characteristicsMajor adverse cardiovascular eventsSmaller minimum lumen areaLow endothelial shear stressHigh-risk anatomyAdverse cardiovascular eventsUseful prognostic informationQuantitative coronary angiographyMinimum lumen areaPrediction of lesionsLipid-rich lesionsESS valuesCoronary angiographyIndependent predictorsMultivariable analysisHemodynamic variablesPrognostic valueVH-IVUSHemodynamic indicesPrognostic informationPredictive value of the QFR in detecting vulnerable plaques in non-flow limiting lesions: a combined analysis of the PROSPECT and IBIS-4 study
Safi H, Bourantas CV, Ramasamy A, Zanchin T, Bär S, Tufaro V, Jin C, Torii R, Karagiannis A, Reiber JHC, Mathur A, Onuma Y, Windecker S, Lansky A, Maehara A, Serruys PW, Stone P, Baumbach A, Stone GW, Räber L. Predictive value of the QFR in detecting vulnerable plaques in non-flow limiting lesions: a combined analysis of the PROSPECT and IBIS-4 study. The International Journal Of Cardiovascular Imaging 2020, 36: 993-1002. PMID: 32152810, DOI: 10.1007/s10554-020-01805-9.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary AngiographyCoronary Artery DiseaseCoronary CirculationCoronary VesselsDisease ProgressionFemaleHumansMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsPrognosisRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesRupture, SpontaneousSeverity of Illness IndexTime FactorsUltrasonography, InterventionalConceptsVirtual histology intravascular ultrasoundQuantitative flow ratioMinimum lumen diameterMinimum lumen areaCoronary angiographyPlaque burdenIBIS-4 studyPrognostic informationVulnerable plaquesSmaller minimum lumen areaMajor adverse cardiac eventsVulnerable phenotypeAdverse cardiac eventsGreater plaque burdenPredictors of MACENon-culprit lesionsAdditional prognostic informationSmaller minimum lumen diameterUseful prognostic informationQuantitative coronary angiographyAdditive valueCardiac eventsPlaque characteristicsLesion severityAngiographic data
2019
P869Predictive value of the endothelial shear stress distribution in three-dimensional quantitative coronary angiography models in detecting vulnerable plaques
Zanchin T, Bourantas C, Torii R, Serruys P, Karagiannis A, Ramasamy A, Onuma Y, Mathur A, Baumbach A, Windecker S, Lansky A, Maehara A, Stone P, Raeber L, Stone G. P869Predictive value of the endothelial shear stress distribution in three-dimensional quantitative coronary angiography models in detecting vulnerable plaques. European Heart Journal 2019, 40: ehz747.0466. DOI: 10.1093/eurheartj/ehz747.0466.Peer-Reviewed Original ResearchHigh endothelial shear stressEndothelial shear stressLow endothelial shear stressQuantitative coronary angiographyMinimum lumen areaPd/PaVulnerable plaquesPlaque burdenSmaller minimum lumen areaMajor adverse cardiac eventsLarge-scale prospective studiesBaseline plaque characteristicsHigh-risk anatomyAdverse cardiac eventsNon-culprit lesionsOnly independent predictorUseful prognostic informationHigh-risk plaquesESS valuesNC-MACECardiac eventsCoronary atherosclerosisCoronary angiographyIndependent predictorsMultivariable analysis
2017
Role of Low Endothelial Shear Stress and Plaque Characteristics in the Prediction of Nonculprit Major Adverse Cardiac Events The PROSPECT Study
Stone PH, Maehara A, Coskun AU, Maynard CC, Zaromytidou M, Siasos G, Andreou I, Fotiadis D, Stefanou K, Papafaklis M, Michalis L, Lansky AJ, Mintz GS, Serruys PW, Feldman CL, Stone GW. Role of Low Endothelial Shear Stress and Plaque Characteristics in the Prediction of Nonculprit Major Adverse Cardiac Events The PROSPECT Study. JACC Cardiovascular Imaging 2017, 11: 462-471. PMID: 28917684, DOI: 10.1016/j.jcmg.2017.01.031.Peer-Reviewed Original ResearchMeSH KeywordsCoronary AngiographyCoronary Artery DiseaseCoronary CirculationCoronary VesselsDisease ProgressionEndothelium, VascularEuropeHumansPercutaneous Coronary InterventionPilot ProjectsPlaque, AtheroscleroticPredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsStress, MechanicalTime FactorsTreatment OutcomeUltrasonography, InterventionalUnited StatesConceptsMajor adverse cardiac eventsLow endothelial shear stressMinimum lumen areaAcute coronary syndromeEndothelial shear stressAdverse cardiac eventsPlaque burdenCoronary lesionsNC-MACECardiac eventsAnatomic riskNC lesionsFuture major adverse cardiac eventsHigh-risk acute coronary syndromesBaseline endothelial shear stressHuman-like animal modelsPrevious natural history studiesPropensity-adjusted Cox regressionSmaller minimum lumen areaPROSPECT studyLocal endothelial shear stressHigh anatomic riskHigh endothelial shear stressNonculprit coronary lesionsHigh-risk patients
2011
Usefulness of Minimum Stent Cross Sectional Area as a Predictor of Angiographic Restenosis After Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction (from the HORIZONS-AMI Trial IVUS Substudy)
Choi SY, Maehara A, Cristea E, Witzenbichler B, Guagliumi G, Brodie B, Kellett MA, Dressler O, Lansky AJ, Parise H, Mehran R, Mintz GS, Stone GW. Usefulness of Minimum Stent Cross Sectional Area as a Predictor of Angiographic Restenosis After Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction (from the HORIZONS-AMI Trial IVUS Substudy). The American Journal Of Cardiology 2011, 109: 455-460. PMID: 22118823, DOI: 10.1016/j.amjcard.2011.10.005.Peer-Reviewed Original ResearchConceptsMinimum stent areaST-segment elevation myocardial infarctionBare-metal stent useElevation myocardial infarctionAngiographic restenosisMyocardial infarctionStent areaIndependent predictorsStent usePrimary percutaneous coronary interventionStable coronary artery diseaseLumen areaMinimum stent cross-sectional areaDifferent antithrombotic regimensIntravascular ultrasound substudyPrimary percutaneous interventionStent cross-sectional areaPercutaneous coronary interventionCoronary artery diseaseAcute myocardial infarctionAverage lumen areaMinimum lumen areaIVUS minimum lumen areaAntithrombotic regimensAttenuated plaqueIntravascular Ultrasound Findings of Early Stent Thrombosis After Primary Percutaneous Intervention in Acute Myocardial Infarction
Choi SY, Witzenbichler B, Maehara A, Lansky AJ, Guagliumi G, Brodie B, Kellett MA, Dressler O, Parise H, Mehran R, Dangas GD, Mintz GS, Stone GW. Intravascular Ultrasound Findings of Early Stent Thrombosis After Primary Percutaneous Intervention in Acute Myocardial Infarction. Circulation Cardiovascular Interventions 2011, 4: 239-247. PMID: 21586693, DOI: 10.1161/circinterventions.110.959791.Peer-Reviewed Original ResearchConceptsEarly stent thrombosisMinimum lumen areaSignificant residual stenosisStent thrombosisAcute myocardial infarctionResidual stenosisEdge dissectionLumen areaAcute malappositionMyocardial infarctionTissue protrusionAcute Myocardial Infarction StudyIntravascular ultrasound predictorsSignificant edge dissectionPrimary percutaneous interventionIntravascular ultrasound findingsMyocardial Infarction StudyStent edge dissectionFinal lumen areaSmaller stent areaFormal substudyHarmonizing OutcomesIVUS predictorsOutflow diseaseStable angina
2010
Serial Intravascular Ultrasound Analysis of the Impact of Myocardial Bridge on Neointimal Proliferation After Coronary Stenting in Patients with Acute Myocardial Infarction
TSUJITA K, MAEHARA A, MINTZ GS, LANSKY AJ, KUBO T, DOI H, YANG J, BHARAJ H, WITZENBICHLER B, GUAGLIUMI G, BRODIE BR, KELLETT MA, PARISE H, MEHRAN R, STONE GW. Serial Intravascular Ultrasound Analysis of the Impact of Myocardial Bridge on Neointimal Proliferation After Coronary Stenting in Patients with Acute Myocardial Infarction. Journal Of Interventional Cardiology 2010, 23: 114-122. PMID: 20236216, DOI: 10.1111/j.1540-8183.2010.00531.x.Peer-Reviewed Original ResearchConceptsCulprit lesionIntimal hyperplasiaIntravascular ultrasoundStent groupMyocardial bridgeLAD stentAcute Myocardial Infarction trialLumen areaSerial intravascular ultrasound analysisMyocardial Infarction trialAcute myocardial infarctionStent recoilSerial intravascular ultrasoundIncidence of ISRIntravascular ultrasound analysisMinimum lumen areaHarmonizing OutcomesCoronary stentingMyocardial infarctionNeointimal proliferationStent restenosisUltrasound analysisStent segmentMb segmentPatients
2006
Volumetric Intravascular Ultrasound Assessment of Neointimal Hyperplasia and Nonuniform Stent Strut Distribution in Sirolimus-Eluting Stent Restenosis
Sano K, Mintz GS, Carlier SG, Fujii K, Takebayashi H, Kimura M, Costa JR, Tanaka K, Costa RA, Lui J, Weisz G, Moussa I, Dangas GD, Mehran R, Lansky AJ, Kreps EM, Collins M, Stone GW, Moses JW, Leon MB. Volumetric Intravascular Ultrasound Assessment of Neointimal Hyperplasia and Nonuniform Stent Strut Distribution in Sirolimus-Eluting Stent Restenosis. The American Journal Of Cardiology 2006, 98: 1559-1562. PMID: 17145209, DOI: 10.1016/j.amjcard.2006.07.030.Peer-Reviewed Original ResearchConceptsMinimum lumen siteStent restenotic lesionsStent areaDiabetes mellitusLumen areaRestenotic lesionsStent strut distributionIH areaMinimal lumen area siteSirolimus-eluting stent implantationVolumetric intravascular ultrasound analysisIntravascular ultrasound assessmentMinimum stent areaIntravascular ultrasound analysisMinimum lumen areaMinimal lumen areaMinimal lumen siteIH responseSES implantationStent implantationUltrasound assessmentStent lengthNeointimal hyperplasiaStent restenosisStrut distributionEffect of Everolimus-Eluting Stents in Different Vessel Sizes (from the Pooled FUTURE I and II Trials)
Tsuchiya Y, Lansky AJ, Costa RA, Mehran R, Pietras C, Shimada Y, Sonoda S, Cristea E, Negoita M, Dangas GD, Moses JW, Leon MB, Fitzgerald PJ, Müller R, Störger H, Hauptmann KE, Grube E. Effect of Everolimus-Eluting Stents in Different Vessel Sizes (from the Pooled FUTURE I and II Trials). The American Journal Of Cardiology 2006, 98: 464-469. PMID: 16893698, DOI: 10.1016/j.amjcard.2006.02.054.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood Vessel Prosthesis ImplantationCoated Materials, BiocompatibleCoronary AngiographyCoronary RestenosisCoronary VesselsEverolimusFemaleFollow-Up StudiesHumansImmunosuppressive AgentsMaleMiddle AgedProspective StudiesProsthesis DesignSirolimusStentsTreatment OutcomeUltrasonography, InterventionalConceptsBare metal stentsDe novo coronary lesionsNovo coronary lesionsCoronary lesionsNeointimal proliferationStent late lumen lossMid-term outcomesLate lumen lossEverolimus-Eluting StentsQuantitative coronary angiographyMinimum lumen areaVessel sizeII trialCoronary angiographyI trialIncomplete appositionLumen lossStent thrombosisAneurysm formationStent restenosisIntravascular ultrasoundMetal stentsReference diameterLumen areaPatients
2004
Nonuniform Strut Distribution Correlates With More Neointimal Hyperplasia After Sirolimus-Eluting Stent Implantation
Takebayashi H, Mintz GS, Carlier S, Kobayashi Y, Fujii K, Yasuda T, Costa RA, Moussa I, Dangas GD, Mehran R, Lansky AJ, Kreps E, Collins MB, Colombo A, Stone GW, Leon MB, Moses JW. Nonuniform Strut Distribution Correlates With More Neointimal Hyperplasia After Sirolimus-Eluting Stent Implantation. Circulation 2004, 110: 3430-3434. PMID: 15557367, DOI: 10.1161/01.cir.0000148371.53174.05.Peer-Reviewed Original ResearchConceptsMinimum lumen siteIntimal hyperplasiaLumen areaStent implantationStent strutsIH areaSmaller minimal lumen areaSirolimus-eluting stent implantationAmount of neointimaMinimum lumen areaMinimal lumen areaIVUS predictorsRestenosis patientsSES implantationRestenosis lesionsStent cellsStent strut distributionNeointimal hyperplasiaStrut distributionIntravascular ultrasoundMultivariate analysisVisible strutsComparison groupCross-sectional areaHyperplasia
2003
Intravascular Ultrasound Assessment of Ulcerated Ruptured Plaques
Fujii K, Kobayashi Y, Mintz GS, Takebayashi H, Dangas G, Moussa I, Mehran R, Lansky AJ, Kreps E, Collins M, Colombo A, Stone GW, Leon MB, Moses JW. Intravascular Ultrasound Assessment of Ulcerated Ruptured Plaques. Circulation 2003, 108: 2473-2478. PMID: 14610010, DOI: 10.1161/01.cir.0000097121.95451.39.Peer-Reviewed Original ResearchConceptsNon-ACS patientsACS patientsAcute coronary syndromeCulprit lesionPlaque ruptureNonculprit lesionsSmaller lumen areaLumen areaPlaque burdenArea stenosisSmaller minimum lumen areaCulprit plaque ruptureGreater plaque burdenIntravascular ultrasound findingsPresence of thrombusIntravascular ultrasound assessmentMinimum lumen areaMinimal lumen siteCoronary syndromeRemodeling indexIndependent predictorsUltrasound assessmentUltrasound findingsRuptured plaquesPatients
1999
Long-Term Follow-Up After Percutaneous Transluminal Coronary Angioplasty Was Not Performed Based on Intravascular Ultrasound Findings
Abizaid A, Mintz G, Mehran R, Abizaid A, Lansky A, Pichard A, Satler L, Wu H, Pappas C, Kent K, Leon M. Long-Term Follow-Up After Percutaneous Transluminal Coronary Angioplasty Was Not Performed Based on Intravascular Ultrasound Findings. Circulation 1999, 100: 256-261. PMID: 10411849, DOI: 10.1161/01.cir.100.3.256.Peer-Reviewed Original ResearchConceptsMinimum lumen areaIntravascular ultrasound findingsOnly independent predictorLumen areaIVUS minimum lumen areaEvent ratesDiabetes mellitusIndependent predictorsUltrasound findingsIVUS parametersArea stenosisLumen diameterPercutaneous transluminal coronary angioplastyLesion lumen areaNative artery lesionsTarget lesion revascularizationTransluminal coronary angioplastyCoronary artery stenosisMinimum lumen diameterLow event ratesArtery lesionsCardiac deathCoronary angioplastyArtery stenosisPlaque burden