2004
Gamma radiation for in‐stent restenosis: effect of lesion length on angiographic and clinical outcomes
Mehran R, Iakovou I, Dangas G, Lansky AJ, Stone GW, Mintz GS, Kent KM, Pichard AD, Satler LF, Fahy M, Leon MB, Waksman R. Gamma radiation for in‐stent restenosis: effect of lesion length on angiographic and clinical outcomes. Catheterization And Cardiovascular Interventions 2004, 61: 354-359. PMID: 14988895, DOI: 10.1002/ccd.10786.Peer-Reviewed Original ResearchConceptsISR groupLesion lengthClinical eventsIn-Stent Restenosis TrialBaseline lesion lengthLower late lossShort lesion groupTreatment of ISRStent restenosis lesionsLong-term outcomesRecurrent ISRRestenosis lesionsRestenosis TrialAngiographic outcomesISR lesionsRestenosis rateClinical outcomesWashington RadiationLate lossStent restenosisLumen dimensionsLong ISRRadiation treatmentPowerful predictorPatients
2003
Intravascular brachytherapy for native coronary ostial in-stent restenotic lesions
Costantini CO, Lansky AJ, Mintz GS, Shirai K, Dangas G, Mehran R, Fahy M, Slack S, Coral M, Teirstein PS, Waksman R, Stone G, Moses J, Leon MB. Intravascular brachytherapy for native coronary ostial in-stent restenotic lesions. Journal Of The American College Of Cardiology 2003, 41: 1725-1731. PMID: 12767655, DOI: 10.1016/s0735-1097(03)00298-5.Peer-Reviewed Original ResearchConceptsAorto-ostial lesionsVascular brachytherapyRecurrence rateOstial ISRRestenosis rateStent restenosisBaseline lesion lengthStent restenotic lesionsHigh recurrence rateBinary restenosisPercutaneous reinterventionPlacebo patientsISR lesionsRestenotic lesionsQuantitative angiographyBeta patientsPatientsPooled databaseConventional treatmentRestenosisPlaceboLesionsLesion lengthBrachytherapySimilar reduction
2001
Intracoronary radiation with gamma wire inhibits recurrent in-stent restenosis
Waksman R, Bhargava B, Chan R, Sherman W, Pisch J, Mintz G, Lansky A, Ahmed J, Ricci N, Liprie S. Intracoronary radiation with gamma wire inhibits recurrent in-stent restenosis. Cardiovascular Revascularization Medicine 2001, 2: 63-68. PMID: 11340009, DOI: 10.1016/s1522-1865(00)00086-x.Peer-Reviewed Original ResearchConceptsIntracoronary gamma radiationTarget lesion revascularizationStent restenosisMyocardial infractionBaseline lesion lengthUnderwent bypass surgeryBinary restenosis rateEvent-free survivalNeointimal tissue proliferationInitial clinical trialsStent restenosis resultsSource wireLesion revascularizationRepeat PTCAAngiographic restenosisPrimary endpointRepeat revascularizationSecondary endpointsBypass surgeryRestenosis rateIntracoronary radiationProcedural successTherapeutic challengeClinical trialsNeointimal hyperplasia