2024
Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease
Sorby-Adams A, Guo J, Laso P, Kirsch J, Zabinska J, Garcia Guarniz A, Schaefer P, Payabvash S, de Havenon A, Rosen M, Sheth K, Gomez-Isla T, Iglesias J, Kimberly W. Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease. Nature Communications 2024, 15: 10488. PMID: 39622805, PMCID: PMC11612292, DOI: 10.1038/s41467-024-54972-x.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesMachine learning pipelineMild cognitive impairmentAlzheimer's diseaseWhite matter hyperintensities volumeLearning pipelineAssessment of patientsIncrease accessCognitive impairmentEvaluation of Alzheimer's diseaseDementiaLF-MRIPoint-of-care assessmentMagnetic resonance imagingHippocampal volumeResonance imagingImage qualityDiseaseReduce costsAnisotropic counterpartIncreasing availabilityManual segmentation
2023
Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia
Clocchiatti‐Tuozzo S, Rivier C, Renedo D, Lopez V, Geer J, Miner B, Yaggi H, de Havenon A, Payabvash S, Sheth K, Gill T, Falcone G. Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia. Journal Of The American Heart Association 2023, 13: e031514. PMID: 38156552, PMCID: PMC10863828, DOI: 10.1161/jaha.123.031514.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainDementiaHumansMagnetic Resonance ImagingMiddle AgedNeuroimagingProspective StudiesSleep DurationStrokeWhite MatterConceptsSuboptimal sleep durationWhite matter hyperintensitiesMiddle-aged individualsLong sleep durationLarger WMH volumeSleep durationMiddle-aged adultsHealth profileWMH volumeAmerican Heart Association's LifeAsymptomatic middle-aged adultsWMH presenceVolume of WMHOptimal sleepSelf-reported sleep durationModifiable risk factorsWhite matter tractsProspective magnetic resonanceSimple 7Cardiovascular healthRisk factorsShort sleepMatter hyperintensitiesHigh riskEarly interventionDetection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke
Mazurek M, Parasuram N, Peng T, Beekman R, Yadlapalli V, Sorby-Adams A, Lalwani D, Zabinska J, Gilmore E, Petersen N, Falcone G, Sujijantarat N, Matouk C, Payabvash S, Sze G, Schiff S, Iglesias J, Rosen M, de Havenon A, Kimberly W, Sheth K. Detection of Intracerebral Hemorrhage Using Low-Field, Portable Magnetic Resonance Imaging in Patients With Stroke. Stroke 2023, 54: 2832-2841. PMID: 37795593, PMCID: PMC11103256, DOI: 10.1161/strokeaha.123.043146.Peer-Reviewed Original ResearchMeSH KeywordsCerebral HemorrhageHumansIschemic StrokeMagnetic Resonance ImagingStrokeTomography, X-Ray ComputedImprovement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity
de Havenon A, Smith E, Sharma R, Falcone G, Bangad A, Prabhakaran S, Sheth K. Improvement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity. Journal Of The American Heart Association 2023, 12: e029374. PMID: 37345754, PMCID: PMC10356061, DOI: 10.1161/jaha.123.029374.Peer-Reviewed Original ResearchMeSH KeywordsAgedCognitive DysfunctionFemaleHumansHypertensionMagnetic Resonance ImagingMaleMiddle AgedPrognosisStrokeWhite MatterConceptsWhite matter hyperintensitiesIncident strokePrimary outcomeHypertensive individualsMatter hyperintensitiesAtherosclerotic cardiovascular disease risk scoreCognitive impairmentCardiovascular disease risk scoreVascular risk factorsCurrent cigarette smokingDisease risk scoreMagnetic resonance imagingLogistic regression modelsRandomization armCerebrovascular eventsVascular riskCigarette smokingPrognostic informationRisk factorsPrognostic abilityRisk scoreCognitive declineResonance imagingDeLong testStrokeIdentification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging
de Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRetrospective StudiesWhite MatterConceptsWhite matter hyperintensitiesMagnetic resonance imagingSevere white matter hyperintensitiesConventional magnetic resonance imagingResonance imagingRetrospective cohortEmergency departmentMatter hyperintensitiesVascular risk factorsProspective observational studyVascular cognitive impairmentTesla magnetic resonance imagingArea Deprivation IndexProspective cohortAdult patientsAcute careRisk factorsCardiovascular diseaseObservational studyCognitive impairmentPatientsCare magnetic resonance imagingIntermodality agreementCohortDeprivation indexFuture of Neurology & Technology: Neuroimaging Made Accessible Using Low-Field, Portable MRI
Parasuram N, Crawford A, Mazurek M, Chavva I, Beekman R, Gilmore E, Petersen N, Payabvash S, Sze G, Eugenio Iglesias J, Omay S, Matouk C, Longbrake E, de Havenon A, Schiff S, Rosen M, Kimberly W, Sheth K. Future of Neurology & Technology: Neuroimaging Made Accessible Using Low-Field, Portable MRI. Neurology 2023, 100: 1067-1071. PMID: 36720639, PMCID: PMC10259275, DOI: 10.1212/wnl.0000000000207074.Peer-Reviewed Original Research
2022
CGRP, Migraine, and Brain MRI in CADASIL
Goldstein E, Gopal N, Badi M, Hodge D, de Havenon A, Glover P, Durham P, Huang J, Lin M, Baradaran H, Majersik J, Meschia J. CGRP, Migraine, and Brain MRI in CADASIL. The Neurologist 2022, 28: 231-236. PMID: 36729391, PMCID: PMC10277309, DOI: 10.1097/nrl.0000000000000478.Peer-Reviewed Original ResearchMeSH KeywordsBrainCADASILCalcitonin Gene-Related PeptideCross-Sectional StudiesHumansMagnetic Resonance ImagingMigraine DisordersNeuroimagingPilot ProjectsRetrospective StudiesConceptsCalcitonin gene-related peptideMigraine-related disabilitySerum calcitonin gene-related peptideSerum CGRP levelsCGRP levelsBrain magnetic resonance imagingCerebral autosomal dominant arteriopathyGene-related peptideAutosomal dominant arteriopathyMagnetic resonance imagingCross-sectional analysisRadiographic associationRadiographic implicationsPrimary outcomeT2 hyperintensityCerebral microbleedsDisability ScaleSubcortical infarctsMigraine pathophysiologyVasoactive peptidesBrain MRIMigraine pathologyMigraineResonance imagingCADASILDirect cost analysis of rapid MRI in the emergency department evaluation of patients suspected of having acute ischemic stroke**
de Havenon A, Orlando C, Delic A, McNally JS, Majersik JJ, Harman T, Alexander M, Reddy V, Lyden S, Anzai Y. Direct cost analysis of rapid MRI in the emergency department evaluation of patients suspected of having acute ischemic stroke**. The Neuroradiology Journal 2022, 36: 142-147. PMID: 35701745, PMCID: PMC10034695, DOI: 10.1177/19714009221108681.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCosts and Cost AnalysisEmergency Service, HospitalFemaleHumansIschemic StrokeMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesStrokeConceptsAcute ischemic strokeHospital lengthIschemic strokeBrain attackRapid MRIAIS patientsEmergency departmentCT perfusionMRI cohortRapid MRI protocolTotal hospital lengthEmergency department evaluationDirect costsNeurologic symptom onsetTotal direct costsDirect cost analysisHospital LOSSequential patientsSymptom onsetDepartment evaluationED LOSPrimary outcomeDischarge diagnosisPatientsMRI protocolStatin Usage Increases White Matter Hyperintensities
Goldstein ED, Garg G, Navarro K, Wolcott Z, Yaghi S, Wong KH, McLean K, de Havenon AH. Statin Usage Increases White Matter Hyperintensities. The Neurologist 2022, 28: 94-98. PMID: 35680399, DOI: 10.1097/nrl.0000000000000448.Peer-Reviewed Original ResearchMeSH KeywordsDisease ProgressionHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMagnetic Resonance ImagingRisk FactorsWhite MatterConceptsWhite matter hyperintensitiesWMH progressionStatin usageTop tertileRisk factorsMatter hyperintensitiesWMH volumeConventional cerebrovascular risk factorsProgression of WMHCerebral small vessel diseaseInfluence of dyslipidemiaCerebrovascular risk factorsInfluence of statinsBaseline WMH volumeSmall vessel diseaseSynergistic risk factorsLow-density lipoproteinFull therapyStatin useVessel diseaseStudy visitWMH developmentPartial therapyWMH dataReductase inhibitors
2021
MR Perfusion in the Evaluation of Mechanical Thrombectomy Candidacy
Muddasani V, de Havenon A, McNally JS, Baradaran H, Alexander MD. MR Perfusion in the Evaluation of Mechanical Thrombectomy Candidacy. Topics In Magnetic Resonance Imaging 2021, 30: 197-204. PMID: 34397969, PMCID: PMC8371677, DOI: 10.1097/rmr.0000000000000277.Peer-Reviewed Original ResearchMeSH KeywordsBrain IschemiaDiffusion Magnetic Resonance ImagingHumansMagnetic Resonance ImagingPerfusionStrokeThrombectomyThrombolytic TherapyConceptsMagnetic resonance imagingIschemic strokeComputed tomographyMR perfusionCore infarctDiffusion-weighted magnetic resonance imagingPerfusion-diffusion mismatchDegree of ischemiaNoncontrast Computed TomographyImproved imaging techniquesSalvageable brainSuperior diagnostic informationIschemic penumbraSymptom onsetAcute evaluationAppropriate imagingPatient selectionStroke therapyThrombolytic therapyPoor outcomePrognostic valueLeading causeEffective treatmentBetter outcomesEarly identificationWhite Matter Hyperintensity and Cardiovascular Disease Outcomes in the SPRINT MIND Trial
Sheibani N, Wong KH, Turan TN, Yeatts SD, Gottesman RF, Prabhakaran S, Rost NS, de Havenon A. White Matter Hyperintensity and Cardiovascular Disease Outcomes in the SPRINT MIND Trial. Journal Of Stroke And Cerebrovascular Diseases 2021, 30: 105764. PMID: 33823461, PMCID: PMC8107132, DOI: 10.1016/j.jstrokecerebrovasdis.2021.105764.Peer-Reviewed Original ResearchConceptsSystolic Blood Pressure Intervention TrialWhite matter hyperintensity volumeSystolic blood pressurePrimary outcomeHazard ratioLog-transformed white matter hyperintensity volumeGoal systolic blood pressureLog-transformed continuous variableComposite of strokeIntensive BP loweringHigh cardiovascular riskAcute coronary syndromeCongestive heart failureProspective clinical trialsCardiovascular disease outcomesFuture CVD riskWhite matter hyperintensitiesSubset of participantsBP loweringCardiovascular deathCardiovascular eventsCoronary syndromeCardiovascular riskCVD riskBlood pressureVessel Wall Enhancement on Black-Blood MRI Predicts Acute and Future Stroke in Cerebral Amyloid Angiopathy
McNally JS, Sakata A, Alexander MD, Dewitt LD, Sonnen JA, Menacho ST, Stoddard GJ, Kim S, de Havenon AH. Vessel Wall Enhancement on Black-Blood MRI Predicts Acute and Future Stroke in Cerebral Amyloid Angiopathy. American Journal Of Neuroradiology 2021, 42: 1038-1045. PMID: 33737266, PMCID: PMC8191668, DOI: 10.3174/ajnr.a7047.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrain IschemiaCerebral Amyloid AngiopathyCerebral HemorrhageFemaleHumansMagnetic Resonance ImagingMaleRetrospective StudiesStrokeConceptsCerebral amyloid angiopathyFuture ischemic strokeVessel wall enhancementIschemic strokeAmyloid angiopathyWall enhancementFuture strokeC-statisticVessel wall MRNew-onset neurologic symptomsInitial ischemic strokeStroke-free survivalAcute ischemic strokeIschemic stroke incidenceCAA patientsFinal regression modelNeurologic symptomsStroke incidenceCerebral amyloidCox regressionRetrospective studyRisk factorsMultivariable PoissonNegative participantsAngiopathy
2020
The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial
Yaghi S, Dehkharghani S, Raz E, Jayaraman M, Tanweer O, Grory BM, Henninger N, Lansberg MG, Albers GW, Havenon A. The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial. Journal Of Stroke And Cerebrovascular Diseases 2020, 30: 105380. PMID: 33166769, PMCID: PMC7736545, DOI: 10.1016/j.jstrokecerebrovasdis.2020.105380.Peer-Reviewed Original ResearchConceptsDEFUSE-3 trialsBaseline glucose levelsInfarct growthGlucose levelsPrimary outcomeAcute ischemic stroke patientsAggressive glycemic controlDEFUSE 3 patientsIschemic core volumePotential neuroprotective benefitsIschemic stroke patientsGood functional outcomeLarge vessel occlusionEffects of hyperglycemiaSuccessful endovascular reperfusionAdmission glucoseInfarction growthEndovascular reperfusionSuccessful reperfusionTICI 2bIschemic strokeNeuroprotective benefitsEndovascular therapyGlycemic controlStroke patientsHow Far Can We Take Vessel Wall MRI for Intracranial Atherosclerosis? The Tissue is Still the Issue
Alexander MD, de Havenon A, Mossa-Basha M, McNally JS. How Far Can We Take Vessel Wall MRI for Intracranial Atherosclerosis? The Tissue is Still the Issue. American Journal Of Neuroradiology 2020, 41: e30-e31. PMID: 32354713, PMCID: PMC7228154, DOI: 10.3174/ajnr.a6501.Peer-Reviewed Original Research
2019
Subclinical Cerebrovascular Disease: Epidemiology and Treatment
de Havenon A, Meyer C, McNally JS, Alexander M, Chung L. Subclinical Cerebrovascular Disease: Epidemiology and Treatment. Current Atherosclerosis Reports 2019, 21: 39. PMID: 31350593, PMCID: PMC8011954, DOI: 10.1007/s11883-019-0799-1.Peer-Reviewed Original ResearchConceptsMedical managementRisk factorsAggressive medical managementSilent brain infarctsOptimal medical treatmentVascular risk factorsDevelopment of dementiaBest medical managementImportant risk factorLate-life depressionCommon clinical scenariosWhite matter hyperintensitiesT2-weighted MRISusceptibility-weighted MRIEvidence-based approachBrain infarctsCerebral microbleedsCerebrovascular diseaseGait instabilityBrain healthClinical equipoiseWorse outcomesClinical trialsMatter hyperintensitiesEpidemiologic studiesCarotid Artery Stiffness Accurately Predicts White Matter Hyperintensity Volume 20 Years Later: A Secondary Analysis of the Atherosclerosis Risk in the Community Study
de Havenon A, Wong K, Elkhetali A, McNally JS, Majersik JJ, Rost NS. Carotid Artery Stiffness Accurately Predicts White Matter Hyperintensity Volume 20 Years Later: A Secondary Analysis of the Atherosclerosis Risk in the Community Study. American Journal Of Neuroradiology 2019, 40: 1369-1373. PMID: 31248859, PMCID: PMC7048485, DOI: 10.3174/ajnr.a6115.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAtherosclerosisBrainCarotid ArteriesFemaleHumansLeukoaraiosisMagnetic Resonance ImagingMaleMiddle AgedUltrasonographyVascular StiffnessWhite MatterConceptsWhite matter hyperintensity volumeCarotid artery stiffnessTotal brain volumePressure-strain elastic modulusArtery stiffnessHyperintensity volumeBrain volumeAtherosclerosis RiskArterial stiffnessMR imagingCommunity studyStiffness indexHigher white matter hyperintensity volumeLower total brain volumeSecondary analysisCommon carotid artery stiffnessSmall artery diseaseMultivariable linear regression modelsCerebrovascular diseaseDementia riskSonography measurementsMultivariate modelCarotid strainPotential mechanismsPatients
2017
Carotid intraplaque hemorrhage on vessel wall MRI does not correlate with TCD emboli monitoring in patients with recently symptomatic carotid atherosclerosis
de Havenon A, Tirschwell D, Majersik JJ, McNally S, Stoddard G, Moore A, Mossa-Basha M. Carotid intraplaque hemorrhage on vessel wall MRI does not correlate with TCD emboli monitoring in patients with recently symptomatic carotid atherosclerosis. The Neuroradiology Journal 2017, 30: 486-489. PMID: 28631982, PMCID: PMC5602332, DOI: 10.1177/1971400917707351.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeSymptomatic carotid atherosclerosisCarotid atherosclerosisMicroembolic signalsIntraplaque hemorrhageCarotid intraplaque hemorrhageTranscranial DopplerVessel wall MRIIschemic strokeEmboli monitoringPresence of IPHRecent acute ischemic strokeTransient ischemic attackWarrants prospective studiesAcute stroke patientsRetrospective chart reviewRisk of strokeIschemic attackChart reviewProspective studyStroke patientsResults TwentyInclusion criteriaLarge cohortVolumetric MRIAssociation of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke
de Havenon A, Haynor DR, Tirschwell DL, Majersik JJ, Smith G, Cohen W, Andre JB. Association of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke. JAMA Neurology 2017, 74: 453-458. PMID: 28192548, PMCID: PMC5470363, DOI: 10.1001/jamaneurol.2016.4491.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeArterial spin labeling magnetic resonance imagingCollateral blood vesselsNeurologic outcomeMRS scoreMagnetic resonance imagingNeurological outcomeIschemic strokeScale scoreHealth Stroke Scale scoreResonance imagingMultivariable ordinal logistic regression modelsTertiary academic medical centerBlood vesselsAdmission National InstitutesPremorbid mRS scoreGood neurologic outcomeGood neurological outcomeRetrospective cohort studyStroke Scale scoreRankin Scale scorePresence of collateralsAcademic medical centerLogistic regression modelsOrdinal logistic regression models
2016
Response to “High-Resolution Vessel Wall MRI: Appearance of Intravascular Lymphoma Mimics Central Nervous System Vasculitis”
de Havenon A, McNally S. Response to “High-Resolution Vessel Wall MRI: Appearance of Intravascular Lymphoma Mimics Central Nervous System Vasculitis”. Clinical Neuroradiology 2016, 26: 501-501. PMID: 27822627, DOI: 10.1007/s00062-016-0547-7.Peer-Reviewed Original ResearchRare case of T-cell lymphoma presenting as acute myelopathy
Samara VC, de Havenon A. Rare case of T-cell lymphoma presenting as acute myelopathy. BMJ Case Reports 2016, 2016: bcr2016217944. PMID: 27769981, PMCID: PMC5093351, DOI: 10.1136/bcr-2016-217944.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedContrast MediaDiagnosis, DifferentialFatal OutcomeHumansLymphoma, T-CellMagnetic Resonance ImagingMaleSpinal Cord DiseasesConceptsT-cell lymphomaAcute myelopathySystemic T-cell lymphomaT-cell lymphoproliferative disorderExtensive T2 hyperintensityLower extremity paresthesiasLower extremity weaknessDiffuse contrast enhancementErythematous maculopapular rashT lymphocyte populationsBone marrow aspirateExtremity weaknessSystemic chemotherapyExtremity paresthesiasMaculopapular rashLymphoproliferative disordersRare presentationT2 hyperintensityPeripheral bloodSpinal MRIMarrow aspiratesRare caseCerebrospinal fluidMyelopathyChemotherapy