2023
Association between blood pressure variability and outcomes after endovascular thrombectomy for acute ischemic stroke: An individual patient data meta-analysis
Palaiodimou L, Joundi R, Katsanos A, Ahmed N, Kim J, Goyal N, Maier I, de Havenon A, Anadani M, Matusevicius M, Mistry E, Khatri P, Arthur A, Sarraj A, Yaghi S, Shoamanesh A, Catanese L, Psychogios M, Malhotra K, Spiotta A, Vassilopoulou S, Tsioufis K, Sandset E, Alexandrov A, Petersen N, Tsivgoulis G. Association between blood pressure variability and outcomes after endovascular thrombectomy for acute ischemic stroke: An individual patient data meta-analysis. European Stroke Journal 2023, 9: 88-96. PMID: 37921233, PMCID: PMC10916831, DOI: 10.1177/23969873231211157.Peer-Reviewed Original ResearchBlood pressure variabilitySymptomatic intracranial hemorrhageAcute ischemic strokeEndovascular thrombectomyFunctional impairmentIschemic strokeHighest tertileAIS patientsPressure variabilityIndividual BP measurementsMean BP levelsDiastolic BP levelsIndividual patient dataLogistic mixed-effects modelsSBP-CVSBP-SDIntravenous thrombolysisStroke outcomeStroke severitySuccessful recanalizationBP levelsIntracranial hemorrhageBP measurementsHigh mortalityTertileEffect of COVID-19 on Acute Ischemic Stroke Severity and Mortality in 2020: Results From the 2020 National Inpatient Sample
de Havenon A, Zhou L, Yaghi S, Frontera J, Sheth K. Effect of COVID-19 on Acute Ischemic Stroke Severity and Mortality in 2020: Results From the 2020 National Inpatient Sample. Stroke 2023, 54: e194-e198. PMID: 37021563, PMCID: PMC10121243, DOI: 10.1161/strokeaha.122.041929.Peer-Reviewed Original ResearchConceptsHealth Stroke ScaleStroke ScaleStroke severityLowest quartileCOVID-19Acute ischemic stroke outcomesAcute ischemic stroke severityHigher stroke severityHospital stroke mortalityIschemic stroke outcomeHigher National InstitutesNational Inpatient SampleCross-sectional cohortIschemic stroke severityCOVID-19 statusNational InstituteHospital mortalityAdjusted riskHospital dischargeIschemic strokeStroke outcomeStroke mortalityAIS severityInpatient SampleExposure status
2017
Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke
de Havenon A, Bennett A, Stoddard GJ, Smith G, Chung L, O'Donnell S, McNally JS, Tirschwell D, Majersik JJ. Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke. Stroke And Vascular Neurology 2017, 2: 1. PMID: 28959484, PMCID: PMC5435214, DOI: 10.1136/svn-2016-000057.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBlood PressureBlood Pressure DeterminationCerebral AngiographyCerebrovascular CirculationCollateral CirculationComputed Tomography AngiographyDisability EvaluationFemaleHumansIschemic StrokeMaleMiddle AgedNeuroimagingPatient AdmissionPerfusion ImagingPredictive Value of TestsPrognosisRecovery of FunctionRetrospective StudiesRisk FactorsTime FactorsConceptsBlood pressure variabilityProximal vessel occlusionAcute ischemic strokeIschemic strokeVessel occlusionNeurological outcomeBPV indicesPressure variabilityAcute anterior circulation ischemic strokeAnterior circulation ischemic strokeIntravenous tissue plasminogen activatorGood collateral vesselsIschemic core volumeLarger mismatch volumeWorse neurological outcomeAcute stroke therapySubset of patientsSystolic blood pressureTissue plasminogen activatorLogistic regression modelsOrdinal logistic regression modelsEndovascular thrombectomyIschemic penumbraStroke onsetStroke outcome
2015
Tissue Plasminogen Activator Prescription and Administration Errors within a Regional Stroke System
Chung LS, Tkach A, Lingenfelter EM, Dehoney SB, Rollo J, de Havenon A, DeWitt LD, Grantz MR, Wang H, Wold JJ, Hannon PM, Weathered NR, Majersik JJ. Tissue Plasminogen Activator Prescription and Administration Errors within a Regional Stroke System. Journal Of Stroke And Cerebrovascular Diseases 2015, 25: 565-571. PMID: 26698642, PMCID: PMC4779727, DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.014.Peer-Reviewed Original ResearchConceptsComprehensive stroke centerRegional stroke systemAcute ischemic strokeCommunity hospitalAdministration errorsStroke systemsWeight-based dosingMean age 68Ischemic strokeStroke centersStroke outcomeAIS patientsCH patientsAge 68Infusion rateSystemic hemorrhageAIS casesBody weightPharmacy informationPatientsIncorrect dosageOutcomesPrescriptionTPAAssociation