2021
Magnitude of blood pressure change and clinical outcomes after thrombectomy in stroke caused by large artery occlusion
Anadani M, Matusevicius M, Tsivgoulis G, Peeters A, Nunes A, Mancuso M, Roffe C, de Havenon A, Ahmed N. Magnitude of blood pressure change and clinical outcomes after thrombectomy in stroke caused by large artery occlusion. European Journal Of Neurology 2021, 28: 1922-1930. PMID: 33682232, DOI: 10.1111/ene.14807.Peer-Reviewed Original ResearchConceptsSystolic blood pressureAssociated with unfavorable outcomesRestricted cubic spline modelsUnfavorable outcomeLow systolic blood pressureRestricted cubic splinesCubic spline modelsLogistic regression modelsMixed logistic regression modelsArtery occlusion strokeMultivariable mixed logistic regression modelsMechanical thrombectomyAssociated with poor functional outcomeSBP increaseAdmission systolic blood pressureHigher SBPPoor functional outcomeMagnitude of blood pressure changesPredictors of unfavorable outcomeIncreased risk of unfavorable outcomeOcclusion strokePrimary outcomeSBP changeRisk of unfavorable outcomeStudy population
2020
Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis
Katsanos A, Alexandrov A, Mandava P, Köhrmann M, Soinne L, Barreto A, Sharma V, Mikulik R, Muir K, Rothlisberger T, Grotta J, Levi C, Molina C, Saqqur M, Palaiodimou L, Psaltopoulou T, Vosko M, Moreira T, Fiebach J, Rubiera M, Sandset E, de Havenon A, Kent T, Alexandrov A, Schellinger P, Tsivgoulis G, Investigators F. Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis. European Journal Of Neurology 2020, 27: 2453-2462. PMID: 32697894, DOI: 10.1111/ene.14447.Peer-Reviewed Original ResearchConceptsPatients treated with intravenous thrombolysisAcute ischaemic strokeIndependent functional outcomePulse pressure variabilityIntravenous thrombolysisIntracranial bleedingAssociated with adverse short-termFunctional outcomesBlood pressureStroke patients treated with intravenous thrombolysisTissue plasminogen activator bolusSystemic tissue plasminogen activatorAssociated with unfavorable outcomesAssociated with worse neurological outcomeSymptomatic intracranial bleedingLong-term functional outcomeSafety end pointPulse pressureAcute ischaemic stroke patientsAdverse short-termLysis of thrombiPressure variabilityTissue plasminogen activatorCombined Lysis of ThrombusIntravenous thrombolysis administration