Evan Vosburgh, MD
he/him/his
Associate Clinical Professor of MedicineAbout
Research
Overview
Clinical benign and malignant hematology; neuroendocrine tumor biology; clinical research
Publications
2022
Tumors of the Diffuse Neuroendocrine and Gastroenteropancreatic System
Vosburgh E. Tumors of the Diffuse Neuroendocrine and Gastroenteropancreatic System. 2022, 1-10. DOI: 10.1002/9781119000822.hfcm083.pub2.Peer-Reviewed Original ResearchPeptide receptor radiotherapyMultiple endocrine neoplasiaDiffuse neuroendocrine systemClinical featuresHepatic metastasesNeuroendocrine tumorsGastroenteropancreatic systemNeuroendocrine systemInformed clinical careUnique clinical syndromeOngoing clinical trialsAbsence of symptomsCancer registry dataUnexplained incidenceReceptor radiotherapyClinical presentationRandomized trialsTherapeutic optionsClinical syndromeMultiple myelomaSomatostatin analoguesSpecific therapyRecent trialsSurvival resultsClinical trials
2020
Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice
Xu EY, Vosburgh E, Wong C, Tang LH, Notterman DA. Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice. Oncotarget 2020, 11: 2718-2739. PMID: 32733644, PMCID: PMC7367653, DOI: 10.18632/oncotarget.27660.Peer-Reviewed Original ResearchTumor suppressor geneCooperative functionMolecular mechanismsTumor suppressor RB1Tumorigenic effectsCre-loxP systemGenetic analysisPTEN pathwaySuppressor geneGenesNeuroendocrine tumorigenesisGenetic alterationsDeletionPTENTrp53MeninHomozygous deletionExpressing cellsPathwayPRBSignificant roleMiceTumorigenesisPreclinical murine modelsMechanism
2019
Two well-differentiated pancreatic neuroendocrine tumor mouse models
Wong C, Tang LH, Davidson C, Vosburgh E, Chen W, Foran DJ, Notterman DA, Levine AJ, Xu EY. Two well-differentiated pancreatic neuroendocrine tumor mouse models. Cell Death & Differentiation 2019, 27: 269-283. PMID: 31160716, PMCID: PMC7206057, DOI: 10.1038/s41418-019-0355-0.Peer-Reviewed Original ResearchConceptsMultiple endocrine neoplasia type 1Neuroendocrine tumorsMouse modelShort latencyPI3K/Akt/mTORPancreatic neuroendocrine tumorsPituitary neuroendocrine tumorsTumor mouse modelAkt/mTORMTOR inhibitor rapamycinCre-loxP systemNeuroendocrine cancerProlonged survivalProlonged latencyMEN1 patientsMouse insulin 1 promoterSame miceMen1 lossTherapeutic opportunitiesType 1Genetic syndromesPTEN lossEarly onsetTumorsTumor developmentAlleles of Insm1 determine whether RIP1-Tag2 mice produce insulinomas or nonfunctioning pancreatic neuroendocrine tumors
Kobayashi S, Contractor T, Vosburgh E, Du YN, Tang LH, Clausen R, Harris CR. Alleles of Insm1 determine whether RIP1-Tag2 mice produce insulinomas or nonfunctioning pancreatic neuroendocrine tumors. Oncogenesis 2019, 8: 16. PMID: 30796198, PMCID: PMC6386750, DOI: 10.1038/s41389-019-0127-1.Peer-Reviewed Original ResearchPancreatic neuroendocrine tumorsNeuroendocrine tumorsRIP1-Tag2 transgenic miceBeta-cell transcription factorsRIP1-Tag2 miceC57BL/6 genetic backgroundCell linesExpression of Insm1Stem cell markersLiver metastasesNonfunctioning tumorsB6 miceLarge tumorsMetastatic tumorsSevere diseaseRT2 miceAnimal modelsInsulinomaTransgenic miceCell transcription factorsInsulin productionGenetic backgroundTumorsHuman insulinomasCell markers
2017
Tumors of the Diffuse Neuroendocrine and Gastroenteropancreatic System
Vosburgh E. Tumors of the Diffuse Neuroendocrine and Gastroenteropancreatic System. 2017, 1-12. DOI: 10.1002/9781119000822.hfcm083.ChaptersDiffuse neuroendocrine systemClinical featuresNeuroendocrine tumorsGastroenteropancreatic systemProgression-free survival benefitNeuroendocrine systemMultiple endocrine neoplasia syndromeInformed clinical careUnique clinical syndromeFive-year survivalOngoing clinical trialsAbsence of symptomsCancer registry dataEndocrine neoplasia syndromeUnexplained incidenceSurvival benefitClinical presentationHepatic metastasesClinical syndromeMultiple myelomaSurvival resultsClinical trialsRegistry dataNeoplasia syndromeClinical care
2016
Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5
Contractor T, Kobayashi S, da Silva E, Clausen R, Chan C, Vosburgh E, Tang LH, Levine AJ, Harris CR. Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5. Oncotarget 2016, 7: 30585-30596. PMID: 27105526, PMCID: PMC5058703, DOI: 10.18632/oncotarget.8874.Peer-Reviewed Original ResearchConceptsComplement C5Liver metastasesAdvanced tumorsNeuroendocrine tumorsMouse modelSmall primary tumorsPancreatic neuroendocrine tumorsTypes of tumorsSmall molecule antagonistsIntratumoral levelsPrimary tumorMale miceComplement C5aMetastasisTumorsMolecule antagonistsMiceHigh frequencySexual dimorphismHuman diseasesMalesFirst reportCD88CD68PMX53
2014
High-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately
Chen W, Wong C, Vosburgh E, Levine A, Foran D, Xu E. High-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately. Journal Of Visualized Experiments 2014 DOI: 10.3791/51639-v.Peer-Reviewed Original ResearchHigh-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately
Chen W, Wong C, Vosburgh E, Levine AJ, Foran DJ, Xu EY. High-throughput Image Analysis of Tumor Spheroids: A User-friendly Software Application to Measure the Size of Spheroids Automatically and Accurately. Journal Of Visualized Experiments 2014, 51639. PMID: 25046278, PMCID: PMC4212916, DOI: 10.3791/51639.Peer-Reviewed Original ResearchConceptsGraphical user interfaceLarge-scale image analysisImage analysis applicationsUser-friendly software applicationFree image analysis softwareImage analysisActive contour algorithmHigh-throughput image analysisHigh-throughput computationTime-consuming processUser interfaceSoftware applicationsImage analysis softwareAnalysis applicationsNumber of applicationsUneven illuminationQuality control workflowContour algorithmAnalysis softwareQuality imagesNoisy backgroundSoftwareAnalysis processImagesEasy quality control
2012
Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Wong C, Vosburgh E, Levine A, Cong L, Xu E. Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy. Journal Of Visualized Experiments 2012 DOI: 10.3791/4218-v.Peer-Reviewed Original ResearchHuman Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy
Wong C, Vosburgh E, Levine AJ, Cong L, Xu EY. Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy. Journal Of Visualized Experiments 2012, 4218. PMID: 22929519, PMCID: PMC3486771, DOI: 10.3791/4218.Peer-Reviewed Original ResearchConceptsNeuroendocrine tumorsNET cell linesDrug treatmentCell linesMetastatic neuroendocrine tumorsMinority of patientsHuman neuroendocrine tumor cell linesNeuroendocrine Tumor TherapyNew therapeutic targetsBiology of NETsNeuroendocrine tumor cell linesSingle-drug effectsHuman NET cell linesLocalized diseaseNET patientsSurvival benefitSystemic therapyRare tumorDrug effectsImmunohistochemical techniquesTherapeutic targetAnimal modelsNET biologyTumor cell linesHuman malignancies
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Yale School of Medicine
West Haven VA Hospital, 950 Campbell Avenue
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