2013
SAD and the Not-So-Single Photoreceptors
Oren DA, Koziorowski M, Desan PH. SAD and the Not-So-Single Photoreceptors. American Journal Of Psychiatry 2013, 170: 1403-1412. PMID: 23929223, DOI: 10.1176/appi.ajp.2013.13010111.Peer-Reviewed Original ResearchConceptsMolecular mechanismsSeasonal affective disorderCircannual regulationCritical regulatorTetrapyrrole pigmentsDevelopment of therapiesRole of rodsInfluence of lightPhotoreceptorsCone photoreceptorsLight treatmentAntidepressant effectsPhysiologyAnimal modelsAffective disordersRecent studiesSingle photoreceptorsPhototransductionRegulatorDisordersRegulationMechanismGasotransmitterRolePigments
2001
Is Seasonal Affective Disorder a Disorder of Circadian Rhythms?
Desan P, Oren D. Is Seasonal Affective Disorder a Disorder of Circadian Rhythms? CNS Spectrums 2001, 6: 487-501. PMID: 15744212, DOI: 10.1017/s1092852900008038.Peer-Reviewed Original Research
1999
Effect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder
Anand A, Darnell A, Miller H, Berman R, Cappiello A, Oren D, Woods S, Charney D. Effect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder. Biological Psychiatry 1999, 45: 972-978. PMID: 10386179, DOI: 10.1016/s0006-3223(98)00293-5.Peer-Reviewed Original ResearchConceptsLong-term remissionBipolar disorderCatecholamine depletionLithium therapyHypomanic symptomsLong-term lithium therapyRandomized double-blind mannerDSM-IV bipolar disorderDouble-blind mannerMechanism of preventionTransient relapseManic relapsePlacebo administrationSerum levelsCatecholamine systemsHomovanillic acidRemissionRelapseDisordersTherapyTest sessionsSymptomsSubjectsSignificant changesMood indices
1997
Gender Differences in Depression.
Blehar M, Oren D. Gender Differences in Depression. Medscape Journal Of Medicine 1997, 2: 3. PMID: 9746677.Peer-Reviewed Original Research
1994
1,25 (OH)2 vitamin D3 levels in seasonal affective disorder: Effects of light
Oren D, Schulkin J, Rosenthal N. 1,25 (OH)2 vitamin D3 levels in seasonal affective disorder: Effects of light. Psychopharmacology 1994, 116: 515-516. PMID: 7701056, DOI: 10.1007/bf02247486.Peer-Reviewed Original ResearchA controlled trial of cyanocobalamin (Vitamin B12) in the treatment of winter seasonal affective disorder
Oren D, Teicher M, Schwartz P, Glod C, Turner E, Ito Y, Sedway J, Rosenthal N, Wehr T. A controlled trial of cyanocobalamin (Vitamin B12) in the treatment of winter seasonal affective disorder. Journal Of Affective Disorders 1994, 32: 197-200. PMID: 7852661, DOI: 10.1016/0165-0327(94)90018-3.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderWinter seasonal affective disorderAffective disordersEffective short-term treatmentWeekly outpatient visitsShort-term treatmentSIGH-SAD scoresPlacebo washoutAntidepressant efficacyOutpatient visitsWashout periodEffective treatmentSame scheduleVitamin B12SAD patientsSignificant differencesTreatmentPatientsWeeksDisordersCyanocobalaminRandom assignmentPlaceboTrialsVisitsPlatelet [3H]paroxetine binding, 5-HT-stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder
Ozaki N, Rosenthal N, Mazzola P, Chiueh C, Hardin T, Garcia-Borreguero D, Schwartz P, Turner E, Oren D, Murphy D. Platelet [3H]paroxetine binding, 5-HT-stimulated Ca2+ response, and 5-HT content in winter seasonal affective disorder. Biological Psychiatry 1994, 36: 458-466. PMID: 7811842, DOI: 10.1016/0006-3223(94)90641-6.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderWinter seasonal affective disorderSAD patientsAffective disordersBrain serotonergic systemSerotonergic measuresSerotonergic abnormalitiesSerotonergic functionDensity-dependent subpopulationsPlatelet turnoverSerotonergic systemPatientsReceptor functionNeurotransmitter aminesTherapy conditionsHigher BmaxLight plateletsPlateletsDisordersPresent studyHeavy plateletsCa2SerotoninA Controlled Trial of Levodopa Plus Carbidopa in the Treatment of Winter Seasonal Affective Disorder
OREN D, MOUL D, SCHWARTZ P, WEHR T, ROSENTHAL N. A Controlled Trial of Levodopa Plus Carbidopa in the Treatment of Winter Seasonal Affective Disorder. Journal Of Clinical Psychopharmacology 1994, 14: 196-200. PMID: 8027416, DOI: 10.1097/00004714-199406000-00007.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderWinter seasonal affective disorderDopaminergic deficiencyAffective disordersItem Hamilton Rating ScaleEfficacy of levodopaUse of levodopaWeekly outpatient visitsHamilton Rating ScalePlacebo washoutAntidepressant efficacyOutpatient visitsWashout periodRate of responseDepression scoresPatientsLevodopaPlaceboCarbidopaRating ScaleIdentical scheduleSAD patientsTreatmentWeeksDisordersExposure to ambient light in patients with winter seasonal affective disorder
Oren D, Moul D, Schwartz P, Brown C, Yamada E, Rosenthal N. Exposure to ambient light in patients with winter seasonal affective disorder. American Journal Of Psychiatry 1994, 151: 591-593. PMID: 8147459, DOI: 10.1176/ajp.151.4.591.Peer-Reviewed Original ResearchConceptsWinter seasonal affective disorderSeasonal affective disorderAffective disordersSeverity of depressionNormal comparison subjectsMorning light exposureNormal subjectsComparison subjectsGreater severityPatientsDepressionDisordersExposure profilesSeverityExposureLight exposureSubjectsShort photoperiodOutpatientsLight monitorWeeksEFFECTS OF LIGHT ON T‐CELLS IN HIV‐INFECTED SUBJECTS ARE NOT DEPENDENT ON HISTORY OF SEASONAL AFFECTIVE DISORDER
Rosenthal N, Brown C, Oren D, Galetto G, Schwartz P, Malley J. EFFECTS OF LIGHT ON T‐CELLS IN HIV‐INFECTED SUBJECTS ARE NOT DEPENDENT ON HISTORY OF SEASONAL AFFECTIVE DISORDER. Photochemistry And Photobiology 1994, 59: 314-319. PMID: 7912442, DOI: 10.1111/j.1751-1097.1994.tb05040.x.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderSuppressor T-cell countsSignificant mood improvementPotential therapeutic valuePlasma cortisol levelsCD8 levelsHigher CD4Treatment modalitiesT cellsLight therapyCortisol levelsCrossover designAffective disordersCell countHIVTherapeutic valueMood improvementBright light conditionsSignificant differencesTreatment conditionsHigher cell countsDisordersSubjectsVisible red lightCount
1993
Effects of phototherapy on electrooculographic ratio in winter seasonal affective disorder
Ozaki N, Rosenthal N, Moul D, Schwartz P, Oren D. Effects of phototherapy on electrooculographic ratio in winter seasonal affective disorder. Psychiatry Research 1993, 49: 99-107. PMID: 8153191, DOI: 10.1016/0165-1781(93)90098-2.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderControl subjectsLight therapyEOG ratiosSAD patientsAffective disordersEffect of phototherapyNormal control subjectsWinter seasonal affective disorderRetinal abnormalitiesPatientsConfounding factorsEOG testingTherapyDisordersSubjectsTest variabilityOutpatientsAbnormalitiesPhototherapySpontaneous eye blink rate in winter seasonal affective disorder
Barbato G, Moul D, Schwartz P, Rosenthal N, Oren D. Spontaneous eye blink rate in winter seasonal affective disorder. Psychiatry Research 1993, 47: 79-85. PMID: 8516420, DOI: 10.1016/0165-1781(93)90057-n.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderNormal control subjectsSpontaneous eye blink rateWinter seasonal affective disorderEye blink rateControl subjectsLight therapyBlink rateAffective disordersPremenopausal female subjectsSAD patientsDrug-free patientsElevated blink ratePatientsBiological markersFemale subjectsSignificant decreaseSignificant differencesTherapyDisordersSignificant changesPossible linkSubjectsTreatmentExploratory analysisSide effects of light therapy in seasonal affective disorder
Levitt A, Joffe R, Moul D, Lam R, Teicher M, Lebegue B, Murray M, Oren D, Schwartz P, Buchanan A. Side effects of light therapy in seasonal affective disorder. American Journal Of Psychiatry 1993, 150: 650-652. PMID: 8465886, DOI: 10.1176/ajp.150.4.650.Peer-Reviewed Original ResearchAn investigation of ophthalmic function in winter seasonal affective disorder
Oren D, Moul D, Schwartz P, Alexander J, Yatnada E, Rosenthal N. An investigation of ophthalmic function in winter seasonal affective disorder. Depression 1993, 1: 29-37. DOI: 10.1002/depr.3050010107.Peer-Reviewed Original ResearchSeasonal affective disorderWinter seasonal affective disorderAffective disordersFarnsworth-Munsell 100 hue testFunction testsIntraocular pressurePattern electroretinogramPupillary sizeLight therapyApplanation tonometerNormal controlsVisual functioningP100 componentB-wave componentHue testOphthalmic functionNeurological pathwaysOphthalmic defectsSignificant differencesPatientsDark adaptationWiley-LissColor visionDisordersLittle evidenceLight visor treament for seasonal affective disorder: A multicenter study
Joffe R, Moul D, Lam R, Levitt A, Teicher M, Lebegue B, Oren D, Buchanan A, Glod C, Murray M, Brown J, Schwartz P. Light visor treament for seasonal affective disorder: A multicenter study. Psychiatry Research 1993, 46: 29-39. PMID: 8464953, DOI: 10.1016/0165-1781(93)90005-2.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderAntidepressant responseLight therapyAffective disordersTreatment of SADSeverity of depressionAntidepressant actionAntidepressant efficacyMulticenter studyMedication statusNonspecific effectsSimilar frequencySignificant differencesTherapyParallel designDisordersTreatmentPrevious studies
1992
Predictors of response to phototherapy in seasonal affective disorder
Oren D, Jacobsen F, Wehr T, Cameron C, Rosenthal N. Predictors of response to phototherapy in seasonal affective disorder. Comprehensive Psychiatry 1992, 33: 111-114. PMID: 1544295, DOI: 10.1016/0010-440x(92)90006-c.Peer-Reviewed Original Research
1991
Usage patterns of phototherapy in seasonal affective disorder
Oren D, Shannon N, Carpenter C, Rosenthal N. Usage patterns of phototherapy in seasonal affective disorder. Comprehensive Psychiatry 1991, 32: 147-152. PMID: 2022114, DOI: 10.1016/0010-440x(91)90007-y.Peer-Reviewed Original ResearchAdaptation to dim light in depressed patients with seasonal affective disorder
Oren D, Joseph-Vanderpool J, Rosenthal N. Adaptation to dim light in depressed patients with seasonal affective disorder. Psychiatry Research 1991, 36: 187-193. PMID: 2017533, DOI: 10.1016/0165-1781(91)90130-h.Peer-Reviewed Original ResearchConceptsSeasonal affective disorderAffective disordersDrug-free healthy controlsSAD patientsManic-depressive illnessWinter seasonal affective disorderPossible trait markerDepressed SAD patientsDepressive episodeDepressed patientsHealthy controlsDark adaptation curvePatientsTrait markerDiminished sensitivityDisordersSupersensitivity