Takuya Toyonaga, MD, PhD
Associate Research Scientist in Radiology & Biomedical Imaging; Associate Director of Imaging, Positron Emission Tomography (PET)
Research & Publications
Biography
News
Coauthors
Selected Publications
- Author Correction: Synaptic loss and its association with symptom severity in Parkinson’s diseaseHolmes S, Honhar P, Tinaz S, Naganawa M, Hilmer A, Gallezot J, Dias M, Yang Y, Toyonaga T, Esterlis I, Mecca A, Van Dyck C, Henry S, Ropchan J, Nabulsi N, Louis E, Comley R, Finnema S, Carson R, Matuskey D. Author Correction: Synaptic loss and its association with symptom severity in Parkinson’s disease. Npj Parkinson's Disease 2024, 10: 55. PMID: 38472206, PMCID: PMC10933370, DOI: 10.1038/s41531-024-00674-6.
- PET Imaging of Rho‐Associated Protein Kinase 2 in A Mouse Model of Alzheimer’s DiseaseZheng C, Nicholson L, Chen B, Toyonaga T, Liu M, Strittmatter S, Carson R, Huang Y, Cai Z. PET Imaging of Rho‐Associated Protein Kinase 2 in A Mouse Model of Alzheimer’s Disease. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.075782.
- Markerless head motion tracking and event-by-event correction in brain PETZeng T, Lu Y, Jiang W, Zheng J, Zhang J, Gravel P, Wan Q, Fontaine K, Mulnix T, Jiang Y, Yang Z, Revilla E, Naganawa M, Toyonaga T, Henry S, Zhang X, Cao T, Hu L, Carson R. Markerless head motion tracking and event-by-event correction in brain PET. Physics In Medicine And Biology 2023, 68: 245019. PMID: 37983915, PMCID: PMC10713921, DOI: 10.1088/1361-6560/ad0e37.
- Dose reduction in dynamic synaptic vesicle glycoprotein 2A PET imaging using artificial neural networksLi A, Yang B, Naganawa M, Fontaine K, Toyonaga T, Carson R, Tang J. Dose reduction in dynamic synaptic vesicle glycoprotein 2A PET imaging using artificial neural networks. Physics In Medicine And Biology 2023, 68: 245006. PMID: 37857316, PMCID: PMC10739622, DOI: 10.1088/1361-6560/ad0535.
- Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion proteinStoner A, Fu L, Nicholson L, Zheng C, Toyonaga T, Spurrier J, Laird W, Cai Z, Strittmatter S. Neuronal transcriptome, tau and synapse loss in Alzheimer’s knock-in mice require prion protein. Alzheimer's Research & Therapy 2023, 15: 201. PMID: 37968719, PMCID: PMC10647125, DOI: 10.1186/s13195-023-01345-z.
- The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-JToyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot J, Matuskey D, Mecca A, Pittman B, Dias M, Nabulsi N, Finnema S, Chen M, Arnsten A, Radhakrishnan R, Skosnik P, D’Souza D, Esterlis I, Huang Y, van Dyck C, Carson R. The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 51: 1012-1022. PMID: 37955791, DOI: 10.1007/s00259-023-06487-8.
- Cross-Attention for Improved Motion Correction in Brain PETCai Z, Zeng T, Lieffrig E, Zhang J, Chen F, Toyonaga T, You C, Xin J, Zheng N, Lu Y, Duncan J, Onofrey J. Cross-Attention for Improved Motion Correction in Brain PET. 2023, 14312: 34-45. PMID: 38174216, PMCID: PMC10758996, DOI: 10.1007/978-3-031-44858-4_4.
- Assessment of Gray Matter Microstructure and Synaptic Density in Alzheimer's Disease: A Multimodal Imaging Study With DTI and SV2A PETSilva-Rudberg J, Salardini E, O'Dell R, Chen M, Ra J, Georgelos J, Morehouse M, Melino K, Varma P, Toyonaga T, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Assessment of Gray Matter Microstructure and Synaptic Density in Alzheimer's Disease: A Multimodal Imaging Study With DTI and SV2A PET. American Journal Of Geriatric Psychiatry 2023, 32: 17-28. PMID: 37673749, PMCID: PMC10840732, DOI: 10.1016/j.jagp.2023.08.002.
- Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s diseaseO'Dell R, Higgins-Chen A, Gupta D, Chen M, Naganawa M, Toyonaga T, Lu Y, Ni G, Chupak A, Zhao W, Salardini E, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C, Mecca A. Principal component analysis of synaptic density measured with [11C]UCB-J PET in early Alzheimer’s disease. NeuroImage Clinical 2023, 39: 103457. PMID: 37422964, PMCID: PMC10338149, DOI: 10.1016/j.nicl.2023.103457.
- Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primatesChen B, Ojha D, Toyonaga T, Tong J, Pracitto R, Thomas M, Liu M, Kapinos M, Zhang L, Zheng M, Holden D, Fowles K, Ropchan J, Nabulsi N, De Feyter H, Carson R, Huang Y, Cai Z. Preclinical evaluation of a brain penetrant PARP PET imaging probe in rat glioblastoma and nonhuman primates. European Journal Of Nuclear Medicine And Molecular Imaging 2023, 50: 2081-2099. PMID: 36849748, DOI: 10.1007/s00259-023-06162-y.
- Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [18F]SDM-16Zheng C, Toyonaga T, Chen B, Nicholson L, Mennie W, Liu M, Spurrier J, Deluca K, Strittmatter S, Carson R, Huang Y, Cai Z. Decreased synaptic vesicle glycoprotein 2A binding in a rodent model of familial Alzheimer's disease detected by [18F]SDM-16. Frontiers In Neurology 2023, 14: 1045644. PMID: 36846134, PMCID: PMC9945093, DOI: 10.3389/fneur.2023.1045644.
- Deep learning-based attenuation map generation with simultaneously reconstructed PET activity and attenuation and low-dose applicationShi L, Zhang J, Toyonaga T, Shao D, Onofrey J, Lu Y. Deep learning-based attenuation map generation with simultaneously reconstructed PET activity and attenuation and low-dose application. Physics In Medicine And Biology 2023, 68: 035014. PMID: 36584395, DOI: 10.1088/1361-6560/acaf49.
- Visualization of synaptic vesicle protein 2A in a rodent model of familial Alzheimer’s disease with a metabolically stable PET probeZheng C, Chen B, Toyonaga T, Liu M, Nicholson L, Deluca K, Strittmatter S, Carson R, Huang Y, Cai Z. Visualization of synaptic vesicle protein 2A in a rodent model of familial Alzheimer’s disease with a metabolically stable PET probe. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.063890.
- Association of synaptic density and glucose metabolism with cognitive performance in early Alzheimer's disease: a PET imaging study with [11C]UCB‐J and [18F]FDGO'Dell R, Mecca A, Waszak J, Sharp E, Chen M, Naganawa M, Toyonaga T, Lu Y, Chupak A, Cooper E, Lam J, Miller A, Waldner E, Weibley H, Zhao Y, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C. Association of synaptic density and glucose metabolism with cognitive performance in early Alzheimer's disease: a PET imaging study with [11C]UCB‐J and [18F]FDG. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.062595.
- P95. Cortical Amyloid Burden is Associated With Basal Forebrain but Not Medial Temporal Lobe Atrophy in Adults at Varying APOE ɛ4 Risk for Alzheimer’s DiseaseKelly K, O'Dell R, Toyonaga T, Barcelos N, Gelernter J, Varma P, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. P95. Cortical Amyloid Burden is Associated With Basal Forebrain but Not Medial Temporal Lobe Atrophy in Adults at Varying APOE ɛ4 Risk for Alzheimer’s Disease. Biological Psychiatry 2022, 91: s125-s126. DOI: 10.1016/j.biopsych.2022.02.329.
- The relationship between cortical amyloid burden and basal forebrain volume in adults at varying APOE ?4 risk for Alzheimer's diseaseKelly K, Toyonaga T, Zhao W, Barcelos N, Gelernter J, Varma P, Nabulsi N, Wyk B, Huang Y, Carson R, van Dyck C, Mecca A. The relationship between cortical amyloid burden and basal forebrain volume in adults at varying APOE ?4 risk for Alzheimer's disease. American Journal Of Geriatric Psychiatry 2022, 30: s25. DOI: 10.1016/j.jagp.2022.01.301.
- Deep learning–based attenuation correction for whole-body PET — a multi-tracer study with 18F-FDG, 68 Ga-DOTATATE, and 18F-FluciclovineToyonaga T, Shao D, Shi L, Zhang J, Revilla EM, Menard D, Ankrah J, Hirata K, Chen MK, Onofrey JA, Lu Y. Deep learning–based attenuation correction for whole-body PET — a multi-tracer study with 18F-FDG, 68 Ga-DOTATATE, and 18F-Fluciclovine. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3086-3097. PMID: 35277742, PMCID: PMC10725742, DOI: 10.1007/s00259-022-05748-2.
- PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal ImagingToyonaga T, Fesharaki-Zadeh A, Strittmatter SM, Carson RE, Cai Z. PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal Imaging. Frontiers In Neuroscience 2022, 16: 787404. PMID: 35345546, PMCID: PMC8957200, DOI: 10.3389/fnins.2022.787404.
- Cerebrospinal fluid and brain PET measures of synaptic density glycoprotein 2A: Biomarkers of synaptic density in Alzheimer’s diseaseMecca A, Ashton N, Chen M, O'Dell R, Naganawa M, Toyonaga T, Zhao W, Nabulsi N, Brinkmalm A, Kvartsberg H, Schöll M, Arnsten A, Huang Y, Blennow K, Zetterberg H, Carson R, van Dyck C, Nilsson J. Cerebrospinal fluid and brain PET measures of synaptic density glycoprotein 2A: Biomarkers of synaptic density in Alzheimer’s disease. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.054831.
- Synaptic density is associated with cognitive performance in Alzheimer’s disease: A PET imaging study with [11C]UCB‐Jvan Dyck C, Sharp E, O'Dell R, Banks E, Bartlett H, Chen M, Naganawa M, Toyonaga T, Harris J, Ni G, Zhao W, Nabulsi N, Wyk B, Huang Y, Arnsten A, Carson R, Mecca A. Synaptic density is associated with cognitive performance in Alzheimer’s disease: A PET imaging study with [11C]UCB‐J. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.054213.
- Super-resolution PET Brain Imaging using Deep LearningRen S, Liu J, Xie H, Toyonaga T, Mirian N, Chen M, Aboian M, Carson R, Liu C. Super-resolution PET Brain Imaging using Deep Learning. 2021, 00: 1-6. DOI: 10.1109/nss/mic44867.2021.9875548.
- Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's diseaseLu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease. NeuroImage 2021, 238: 118248. PMID: 34119639, PMCID: PMC8454285, DOI: 10.1016/j.neuroimage.2021.118248.
- Synaptic Loss is Associated With Cognitive Impairment in Early Alzheimer’s Disease: A PET Imaging Study With [11C]UCB-JO'Dell R, Mecca A, Sharp E, Banks E, Bartlett H, Chen M, Naganawa M, Toyonaga T, Harris J, Ni G, Zhao W, Nabulsi N, Wyk B, Huang Y, Carson R, Arnsten A, van Dyck C. Synaptic Loss is Associated With Cognitive Impairment in Early Alzheimer’s Disease: A PET Imaging Study With [11C]UCB-J. Biological Psychiatry 2021, 89: s107-s108. DOI: 10.1016/j.biopsych.2021.02.276.
- Principal component analysis of synaptic density measured with [11C]UCB-J PET in Alzheimer's diseaseO'Dell R, Higgins-Chen A, Gupta D, Chen M, Naganawa M, Toyonaga T, Lu Y, Banks E, Bartlett H, Harris J, Zhao W, Nabulsi N, Wyk B, Huang Y, Arnsten A, Carson R, van Dyck C, Mecca A. Principal component analysis of synaptic density measured with [11C]UCB-J PET in Alzheimer's disease. American Journal Of Geriatric Psychiatry 2021, 29: s47-s48. DOI: 10.1016/j.jagp.2021.01.041.
- Synaptic density is associated with cognitive performance in early Alzheimer's disease: a PET imaging study with [11C]UCB-JSharp E, O'Dell R, Banks E, Bartlett H, Chen M, Naganawa M, Toyonaga T, Harris J, Ni G, Zhao W, Nabulsi N, Wyk B, Huang Y, Arnsten A, Carson R, Mecca A, van Dyck C. Synaptic density is associated with cognitive performance in early Alzheimer's disease: a PET imaging study with [11C]UCB-J. American Journal Of Geriatric Psychiatry 2021, 29: s119-s120. DOI: 10.1016/j.jagp.2021.01.114.
- Association of Aß deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [11C]UCB-JO'Dell R, Mecca A, Chen M, Naganawa M, Toyonaga T, Lu Y, Godek T, Harris J, Bartlett H, Banks E, Kominek V, Zhao W, Nabulsi N, Ropchan J, Ye Y, Wyk B, Huang Y, Arnsten A, Carson R, van Dyck C. Association of Aß deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [11C]UCB-J. American Journal Of Geriatric Psychiatry 2021, 29: s37-s40. DOI: 10.1016/j.jagp.2021.01.034.
- Validation of a simplified tissue‐to‐reference ratio measurement using SUVR for the assessment of synaptic density alterations in Alzheimer’s disease using [11C]UCB‐J PETO'Dell R, Naganawa M, Toyonaga T, Young J, Dahal R, Singh E, Waheed A, Banks E, Harris J, Chen M, Nabulsi N, Huang Y, Carson R, van Dyck C, Mecca A. Validation of a simplified tissue‐to‐reference ratio measurement using SUVR for the assessment of synaptic density alterations in Alzheimer’s disease using [11C]UCB‐J PET. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.045928.
- In vivo measurement of widespread synaptic loss and associated tau accumulation in early Alzheimer’s diseaseMecca A, O'Dell R, Chen M, Naganawa M, Toyonaga T, Godek T, Harris J, Bartlett H, Zhao W, Gallezot J, Nabulsi N, Ropchan J, Ye Y, Wyk B, Arnsten A, Huang Y, Carson R, van Dyck C. In vivo measurement of widespread synaptic loss and associated tau accumulation in early Alzheimer’s disease. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.037791.
- Association between cerebral amyloid accumulation and synaptic density in Alzheimer’s disease: A multitracer PET studyO'Dell R, Mecca A, Chen M, Godek T, Harris J, Bartlett H, Banks E, Kominek V, Zhao W, Naganawa M, Toyonaga T, Lu Y, Nabulsi N, Ropchan J, Ye Y, Wyk B, Varma P, Arnsten A, Huang Y, Carson R, van Dyck C. Association between cerebral amyloid accumulation and synaptic density in Alzheimer’s disease: A multitracer PET study. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.043631.
- Association between cerebrospinal fluid biomarkers of neurodegeneration and PET measurements of synaptic density in Alzheimer’s diseaseMecca A, Ashton N, Chen M, O'Dell R, Naganawa M, Toyonaga T, Harris J, Bartlett H, Banks E, Kominek V, Nabulsi N, Najafzadeh S, Wyk B, Brinkmalm A, Kvartsberg H, Schöll M, Arnsten A, Huang Y, Blennow K, Zetterberg H, Carson R, van Dyck C. Association between cerebrospinal fluid biomarkers of neurodegeneration and PET measurements of synaptic density in Alzheimer’s disease. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.044211.
- PET Imaging of Synaptic Vesicle Protein 2AFinnema S, Li S, Cai Z, Naganawa M, Chen M, Matuskey D, Nabulsi N, Esterlis I, Holmes S, Radhakrishnan R, Toyonaga T, Huang Y, Carson R. PET Imaging of Synaptic Vesicle Protein 2A. 2020, 993-1019. DOI: 10.1007/978-3-030-53176-8_29.
- Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [11C]UCB‐J positron emission tomography studyFinnema SJ, Toyonaga T, Detyniecki K, Chen M, Dias M, Wang Q, Lin S, Naganawa M, Gallezot J, Lu Y, Nabulsi NB, Huang Y, Spencer DD, Carson RE. Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [11C]UCB‐J positron emission tomography study. Epilepsia 2020, 61: 2183-2193. PMID: 32944949, DOI: 10.1111/epi.16653.
- ASSOCIATION BETWEEN CEREBRAL AMYLOID ACCUMULATION AND SYNAPTIC DENSITY IN ALZHEIMER'S DISEASE: A MULTITRACER PET STUDYO'Dell R, Mecca A, Chen M, Godek T, Harris J, Bartlett H, Zhao W, Naganawa M, Toyonaga T, Lu Y, Nabulsi N, Wyk B, Varma P, Arnsten A, Huang Y, Carson R, van Dyck C. ASSOCIATION BETWEEN CEREBRAL AMYLOID ACCUMULATION AND SYNAPTIC DENSITY IN ALZHEIMER'S DISEASE: A MULTITRACER PET STUDY. American Journal Of Geriatric Psychiatry 2020, 28: s123-s124. DOI: 10.1016/j.jagp.2020.01.153.
- A Novel Loss Function Incorporating Imaging Acquisition Physics for PET Attenuation Map Generation Using Deep LearningShi L, Onofrey J, Revilla E, Toyonaga T, Menard D, Ankrah J, Carson R, Liu C, Lu Y. A Novel Loss Function Incorporating Imaging Acquisition Physics for PET Attenuation Map Generation Using Deep Learning. 2019, 11767: 723-731. DOI: 10.1007/978-3-030-32251-9_79.
- P2‐349: ASSOCIATION BETWEEN MGLUR5 AND SYNAPTIC DENSITY: A MULTI‐TRACER STUDY OF HEALTHY AGING AND ALZHEIMER'S DISEASEMecca A, Chen M, Godek T, Harris J, Bartlett H, Toyonaga T, Naganawa M, Salardini A, Arnsten A, Nabulsi N, Lim K, Najafzadeh S, Ropchan J, Huang Y, Carson R, Strittmatter S, van Dyck C. P2‐349: ASSOCIATION BETWEEN MGLUR5 AND SYNAPTIC DENSITY: A MULTI‐TRACER STUDY OF HEALTHY AGING AND ALZHEIMER'S DISEASE. Alzheimer's & Dementia 2019, 15: p729-p729. DOI: 10.1016/j.jalz.2019.06.2756.
- IC‐P‐140: ASSOCIATION BETWEEN MGLUR5 AND SYNAPTIC DENSITY: A MULTI‐TRACER STUDY IN HEALTHY AGING AND ALZHEIMER'S DISEASEMecca A, Chen M, Godek T, Harris J, Bartlett H, Toyonaga T, Naganawa M, Salardini A, Arnsten A, Nabulsi N, Lim K, Najafzadeh S, Ropchan J, Huang Y, Carson R, Strittmatter S, van Dyck C. IC‐P‐140: ASSOCIATION BETWEEN MGLUR5 AND SYNAPTIC DENSITY: A MULTI‐TRACER STUDY IN HEALTHY AGING AND ALZHEIMER'S DISEASE. Alzheimer's & Dementia 2019, 15: p115-p115. DOI: 10.1016/j.jalz.2019.06.4254.
- P4‐481: ASSOCIATION BETWEEN ENTORHINAL CORTICAL TAU ACCUMULATION AND HIPPOCAMPAL SYNAPTIC DENSITY IN OLDER INDIVIDUALS WITH NORMAL COGNITION AND EARLY ALZHEIMER'S DISEASE: PRELIMINARY EXPERIENCEMecca A, Chen M, Naganawa M, Toyonaga T, Godek T, Harris J, Bartlett H, Gallezot J, Charil A, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C. P4‐481: ASSOCIATION BETWEEN ENTORHINAL CORTICAL TAU ACCUMULATION AND HIPPOCAMPAL SYNAPTIC DENSITY IN OLDER INDIVIDUALS WITH NORMAL COGNITION AND EARLY ALZHEIMER'S DISEASE: PRELIMINARY EXPERIENCE. Alzheimer's & Dementia 2019, 15: p1497-p1497. DOI: 10.1016/j.jalz.2019.08.027.
- In Vivo Synaptic Density Imaging with 11C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer DiseaseToyonaga T, Smith LM, Finnema SJ, Gallezot JD, Naganawa M, Bini J, Mulnix T, Cai Z, Ropchan J, Huang Y, Strittmatter SM, Carson RE. In Vivo Synaptic Density Imaging with 11C-UCB-J Detects Treatment Effects of Saracatinib in a Mouse Model of Alzheimer Disease. Journal Of Nuclear Medicine 2019, 60: 1780-1786. PMID: 31101744, PMCID: PMC6894376, DOI: 10.2967/jnumed.118.223867.
- IC‐P‐183: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCEMecca A, Chen M, Naganawa M, Finnema S, Toyonaga T, Lin S, Gallezot J, McDonald J, Michalak H, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C. IC‐P‐183: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCE. Alzheimer's & Dementia 2018, 14: p152-p153. DOI: 10.1016/j.jalz.2018.06.2250.
- P2‐365: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCEChen M, Mecca A, Naganawa M, Finnema S, Toyonaga T, Gallezot J, McDonald J, Michalak H, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C. P2‐365: PET IMAGING OF SYNAPTIC DENSITY (SYNAPTIC VESICLE GLYCOPROTEIN 2A, SV2A) IN ALZHEIMER'S DISEASE: INITIAL EXPERIENCE. Alzheimer's & Dementia 2018, 14: p832-p832. DOI: 10.1016/j.jalz.2018.06.1056.
- Poster Number: NR 14 Initial Experience with PET Imaging of Synaptic Density (SV2A) in Alzheimer's Disease: A New Biomarker for Clinical Trials?Mecca A, Chen M, Naganawa M, Finnema S, Toyonaga T, Lin S, McDonald J, Michalak H, Nabulsi N, Huang Y, Arnsten A, Carson R, van Dyck C. Poster Number: NR 14 Initial Experience with PET Imaging of Synaptic Density (SV2A) in Alzheimer's Disease: A New Biomarker for Clinical Trials? American Journal Of Geriatric Psychiatry 2018, 26: s145-s146. DOI: 10.1016/j.jagp.2018.01.176.
- Players of ‘hypoxia orchestra’ – what is the role of FMISO?Toyonaga T, Hirata K, Shiga T, Nagara T. Players of ‘hypoxia orchestra’ – what is the role of FMISO? European Journal Of Nuclear Medicine And Molecular Imaging 2017, 44: 1679-1681. PMID: 28634683, DOI: 10.1007/s00259-017-3754-9.
- Hypoxic glucose metabolism in glioblastoma as a potential prognostic factorToyonaga T, Yamaguchi S, Hirata K, Kobayashi K, Manabe O, Watanabe S, Terasaka S, Kobayashi H, Hattori N, Shiga T, Kuge Y, Tanaka S, Ito YM, Tamaki N. Hypoxic glucose metabolism in glioblastoma as a potential prognostic factor. European Journal Of Nuclear Medicine And Molecular Imaging 2016, 44: 611-619. PMID: 27752745, DOI: 10.1007/s00259-016-3541-z.
- Monte Carlo-based scatter correction considering the tailing effect of a CdTe detector for dual-isotope brain SPECT imagingSuzuki A, Takeuchi W, Ueno Y, Kobashi K, Toyonaga T, Shiga T, Tamaki N. Monte Carlo-based scatter correction considering the tailing effect of a CdTe detector for dual-isotope brain SPECT imaging. Biomedical Physics & Engineering Express 2016, 2: 045010. DOI: 10.1088/2057-1976/2/4/045010.
- 18F-fluoromisonidazole positron emission tomography can predict pathological necrosis of brain tumorsToyonaga T, Hirata K, Yamaguchi S, Hatanaka KC, Yuzawa S, Manabe O, Kobayashi K, Watanabe S, Shiga T, Terasaka S, Kobayashi H, Kuge Y, Tamaki N. 18F-fluoromisonidazole positron emission tomography can predict pathological necrosis of brain tumors. European Journal Of Nuclear Medicine And Molecular Imaging 2016, 43: 1469-1476. PMID: 26841941, DOI: 10.1007/s00259-016-3320-x.