Kelly Cosgrove, PhD
Professor of Psychiatry and of Neuroscience and of Radiology and Biomedical ImagingCards
Appointments
Additional Titles
Co-Director of the T32 Translational Alcohol Research Program, Psychiatry and Public Health
Contact Info
Psychiatry
300 George St
New Haven, CT 06511-
United States
Appointments
Additional Titles
Co-Director of the T32 Translational Alcohol Research Program, Psychiatry and Public Health
Contact Info
Psychiatry
300 George St
New Haven, CT 06511-
United States
Appointments
Additional Titles
Co-Director of the T32 Translational Alcohol Research Program, Psychiatry and Public Health
Contact Info
Psychiatry
300 George St
New Haven, CT 06511-
United States
About
Titles
Professor of Psychiatry and of Neuroscience and of Radiology and Biomedical Imaging
Co-Director of the T32 Translational Alcohol Research Program, Psychiatry and Public Health
Biography
Dr. Cosgrove uses positron emission tomography (PET) to gain insights into the brains of people after they’ve stopped using alcohol and drugs. Trained as a clinical psychologist who worked with individuals managing alcohol and drug addiction, Dr. Cosgrove transitioned to conducting research in order to find more effective ways of helping patients recover from addiction and avoid relapse. Her laboratory develops and uses creative PET imaging paradigms to track changes in critical neurochemicals during the recovery from addiction.
Appointments
Psychiatry
ProfessorPrimaryNeuroscience
ProfessorSecondaryRadiology & Biomedical Imaging
ProfessorSecondary
Other Departments & Organizations
- Center for Nicotine and Tobacco Use Research at Yale (CENTURY)
- Cosgrove Lab
- Division of Women's Behavioral Health Research
- Interdepartmental Neuroscience Program
- Morris-Cosgrove Lab
- MR Center
- Neuroscience
- Neuroscience Research Training Program (NRTP)
- Neuroscience Track
- Positron Emission Tomography (PET)
- Psychiatry
- Psychology Section
- Radiology & Biomedical Imaging
- Translational Brain Imaging Program
- VA Alcohol Research Center
- WHRY Pilot Project Program Investigators
- Women's Health Research at Yale
- Yale Cocaine Research Clinic
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Translational Center to Develop Gender-Sensitive Treatment for Tobacco Dependence
- Yale Ventures
Education & Training
- Psychology Intern
- Medical University of South Carolina (2003)
- PhD
- University of Minnesota (2002)
- BS
- University of Minnesota (1997)
Research
Overview
- Understanding the functional basis and behavioral and cognitive correlates of the changes in beta2*-nicotinic acetylcholine receptor availability during acute and prolonged abstinence in tobacco smokers.
- Examining the changes in mglu5 receptor availability that occur during acute and prolonged abstinence from alcohol and nicotine dependence.
- Radiotracer development targeted at the stress and glucocorticoid systems.
- Examination of sex differences in the dopaminergic signature of smoking- and nicotine-induced dopamine release using novel PET brain imaging techniques.
- Examining effects of chronic alcohol consumption on the neuroimmune system and relationships to synaptic plasticity in living humans with alcohol use disorder.
- Examining the stress and neuroimmune system with PET and the application to psychiatric disorders such as PTSD.
- Measuring the neuroimmune state of the brain in individuals with opioid use disorder during early recovery.
Medical Subject Headings (MeSH)
ORCID
0000-0003-1351-9576- View Lab Website
Cosgrove Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Nabeel Nabulsi, PhD
Sherry McKee, PhD
David Matuskey, MD
Richard Carson, PhD
Ansel Hillmer, PhD
Yasmin Zakiniaeiz, PhD
Positron-Emission Tomography
Brain
Neuroimaging
Nicotine
Alcohol Drinking
Publications
2024
Translational PET Imaging of HDAC6 Using 18F-Bavarostat in PTSD
Bonomi R, Girgenti M, Naganawa M, Matuskey D, Cosgrove K. Translational PET Imaging of HDAC6 Using 18F-Bavarostat in PTSD. Biological Psychiatry 2024, 95: s40-s41. DOI: 10.1016/j.biopsych.2024.02.102.Peer-Reviewed Original Research361. Imaging HDAC6 in PTSD
Bonomi R, Girgenti M, Cosgrove K. 361. Imaging HDAC6 in PTSD. Biological Psychiatry 2024, 95: s247. DOI: 10.1016/j.biopsych.2024.02.860.Peer-Reviewed Original ResearchDoes seasonal variation affect the neuroimmune system? A retrospective [11C]PBR28 PET study in healthy individuals
Ibrahim W, An J, Yang Y, Cosgrove K, Matuskey D. Does seasonal variation affect the neuroimmune system? A retrospective [11C]PBR28 PET study in healthy individuals. Neuroscience Letters 2024, 828: 137766. PMID: 38583505, PMCID: PMC11073647, DOI: 10.1016/j.neulet.2024.137766.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsTranslocator protein levelsPositron emission tomographyNeuroimmune systemHealthy individualsHuman studiesPositron emission tomography scanTranslocator proteinTest-retest variabilityBrain TSPO levelsVolume of distributionPositron emission tomography imagingBrain regionsCentral nervous systemTranslocator protein expressionGene polymorphismsCell markersHealthy subjectsTSPO levelsInterindividual variabilityNeuropsychiatric disordersEmission tomographyPET studiesNervous systemMonthsNo significant effectSubstance use and spine density: a systematic review and meta-analysis of preclinical studies
Oliva H, Prudente T, Nunes E, Cosgrove K, Radhakrishnan R, Potenza M, Angarita G. Substance use and spine density: a systematic review and meta-analysis of preclinical studies. Molecular Psychiatry 2024, 1-13. PMID: 38561468, DOI: 10.1038/s41380-024-02519-3.Peer-Reviewed Original ResearchAltmetricConceptsSpine densityPrefrontal cortexSubstance useDrug self-administrationHippocampal spine densityEffects of cocaineSubstance use disordersConvergence of findingsSpine density changesSubstances of abuseMeta-analysis of preclinical studiesNucleus accumbensBehavioral sensitizationSelf-administrationBrain mechanismsPreclinical studiesBrain regionsMorphine effectsSynaptic density changesMeta-analysisAmphetamineSynaptic densityCocaineModerate-to-highCortexLower Dorsal Putamen D2/3 Receptor Availability and Amphetamine-Induced Dopamine Release are Related to Poorer Cognitive Function in Recently Abstinent People Who Smoke and Healthy Controls
Cheung F, Calakos K, Gueorguieva R, Hillmer A, Cosgrove K, Zakiniaeiz Y. Lower Dorsal Putamen D2/3 Receptor Availability and Amphetamine-Induced Dopamine Release are Related to Poorer Cognitive Function in Recently Abstinent People Who Smoke and Healthy Controls. Nicotine & Tobacco Research 2024, 26: 1038-1044. PMID: 38367211, PMCID: PMC11260895, DOI: 10.1093/ntr/ntae031.Peer-Reviewed Original ResearchAltmetricConceptsAmphetamine-induced dopamine releaseBrain-behavior relationshipsAbstinent peopleDorsal striatumCognitive functionDopamine releasePoorer cognitive functionD2/3R availabilityDelayed recallHealthy controlsTests of verbal learningDysregulated dopamine signalingD2/3 receptor availabilityDrug-seeking behaviorDorsolateral prefrontal cortexCogState computerized batteryPositron emission tomography scanAmphetamine administrationMesocortical pathwayMesolimbic pathwayDopamine systemPrefrontal cortexVerbal learningBaseline BPNDDopamine signalingImaging a putative marker of brain cortisol regulation in alcohol use disorder
Verplaetse T, Hillmer A, Bhatt S, Rusowicz A, Li S, Nabulsi N, Matuskey D, Huang Y, McKee S, Cosgrove K. Imaging a putative marker of brain cortisol regulation in alcohol use disorder. Neurobiology Of Stress 2024, 29: 100609. PMID: 38304303, PMCID: PMC10832501, DOI: 10.1016/j.ynstr.2024.100609.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAlcohol use disorderAnterior cingulate cortexDrinking days/weekModerate to severe alcohol use disorderHealthy controlsHypothalamic-pituitary-adrenal (HPA) axisSevere alcohol use disorderPositron emission tomographyHPA axis dysfunctionHPA axis functionRelease of glucocorticoid hormonesAlcohol consumptionAssociated with drinkingVentromedial PFCCingulate cortexHigh-resolution research tomographHPA activityUse disorderDrinking episodesCortisol regulationAxis functionVmPFCPeripheral cortisolBrain availabilityDisordered backgroundThe role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications
Peltier M, Verplaetse T, Altemus M, Zakiniaeiz Y, Ralevski E, Mineur Y, Gueorguieva R, Picciotto M, Cosgrove K, Petrakis I, McKee S. The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications. Frontiers In Neuroendocrinology 2024, 73: 101119. PMID: 38184208, PMCID: PMC11185997, DOI: 10.1016/j.yfrne.2023.101119.Peer-Reviewed Original ResearchCitationsConceptsPosttraumatic stress disorderAlcohol use disorderStress disorderContext of PTSDPTSD/AUDConcurrent posttraumatic stress disorderUnderlying neurobiological mechanismsUse disordersAlcohol-related variablesNeurobiological mechanismsPTSD diagnosisTreatment developmentTreatment implicationsBody of literatureNovel interventionsClinical literatureRole of neurosteroidsDisordersTreatment outcomesYears of researchAlcohol consumptionExogenous pregnenolonePharmacological treatmentBiological variablesAllopregnanolone
2023
Imaging the brain’s immune response to alcohol with [11C]PBR28 TSPO Positron Emission Tomography
Raval N, Angarita G, Matuskey D, Miller R, Drake L, Kapinos M, Nabulsi N, Huang Y, Carson R, O’Malley S, Cosgrove K, Hillmer A. Imaging the brain’s immune response to alcohol with [11C]PBR28 TSPO Positron Emission Tomography. Molecular Psychiatry 2023, 28: 3384-3390. PMID: 37532797, PMCID: PMC10743097, DOI: 10.1038/s41380-023-02198-6.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVolume of distributionBlood alcohol levelsPositron emission tomographyBrain immune responseImmune responseAlcohol challengeEmission tomographyPeak blood alcohol levelsMultilinear analysis 1Peripheral immune functionVivo human evidenceLaboratory alcohol challengeTSPO positron emission tomographyBinge levelsPlasma cytokinesImmune dysfunctionNeuroimmune systemIL-6MCP-1Cytokines TNFAcute effectsScan dayArterial bloodHuman evidenceImmune functionDeveloping Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs
Zakiniaeiz Y, Peltier M, Mineur Y, Gueorguieva R, Picciotto M, Petrakis I, Cosgrove K, McKee S. Developing Researchers with Expertise in Sex as a Biological Variable through SCORE Career Enhancement Core Center Programs. Journal Of Women's Health 2023, 32: 852-857. PMID: 37585509, PMCID: PMC10457604, DOI: 10.1089/jwh.2023.0015.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsSex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes
Zakiniaeiz Y, Gueorguieva R, Peltier M, Verplaetse T, Roberts W, McKee S, Cosgrove K. Sex steroid hormone levels associated with dopamine D2/3 receptor availability in people who smoke cigarettes. Frontiers In Behavioral Neuroscience 2023, 17: 1192740. PMID: 37358969, PMCID: PMC10288103, DOI: 10.3389/fnbeh.2023.1192740.Peer-Reviewed Original ResearchConceptsSex steroid hormone levelsSteroid hormone levelsLow estradiol levelsTobacco smokingSex-matched counterpartsHormone levelsFree testosteroneEstradiol levelsAmphetamine administrationR availabilityPositron emission tomography scanPrimary addictive componentEmission tomography scanDopamine D2/3 receptor availabilityEffects of nicotineSex steroid hormonesAge-matched controlsCortical brain regionsD2/3 receptor availabilityNicotinic acetylcholine receptorsSex differencesDorsolateral prefrontal cortexDrug-taking behaviorDopaminergic actionsAddictive component
Clinical Trials
Current Trials
The Effect of Acute Stress and Inflammation on Drinking
HIC ID2000028772RoleSub InvestigatorPrimary Completion Date06/30/2022Recruiting ParticipantsGenderBothAge21 years - 65 yearsImaging cortisol metabolism in liver, adipose tissue and brain with a novel PET radioligand
HIC ID2000029576RoleSub InvestigatorPrimary Completion Date06/30/2024Recruiting ParticipantsEligibility for Participation in Neuroimaging Studies
HIC ID2000027842RoleSub InvestigatorPrimary Completion Date12/31/2023Recruiting ParticipantsHPA axis function in the brains of PTSD, Trauma Exposed, or Otherwise Healthy research participants utilizing PET and MRI imaging
HIC ID2000028748RolePrincipal InvestigatorPrimary Completion Date08/31/2025Recruiting ParticipantsGenderBothAge18 years - 55 yearsImaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
HIC ID1005006735RoleSub InvestigatorPrimary Completion Date12/31/2016Recruiting ParticipantsGenderMaleAge18 years - 55 years
Links & Media
News
- August 23, 2024
Microglia-Mediated Neuroimmune Suppression in PTSD Is Associated With Anhedonia
- April 02, 2024Source: Molecular Psychiatry
Substance Use and Spine Density: A Systematic Review and Meta-Analysis of Preclinical Studies
- February 26, 2024
CASE Announces Newly Elected Members
- February 26, 2024
Blumberg, Cosgrove, Pittenger Elected to Connecticut Academy of Science & Engineering
Get In Touch
Contacts
Psychiatry
300 George St
New Haven, CT 06511-
United States
Locations
Temple Medical Center
Academic Office
40 Temple Street, Ste 7C
New Haven, CT 06510