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INFORMATION FOR

    Zyad James Carr, MD

    Associate Professor of Anesthesiology
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    Additional Titles

    Medical Director, Pre-Surgical Evaluation Clinic, Yale New Haven Hospital, Anesthesiology

    Contact Info

    Anesthesiology

    333 Cedar Street, TMP-3

    New Haven, Connecticut 05610

    United States

    About

    Titles

    Associate Professor of Anesthesiology

    Medical Director, Pre-Surgical Evaluation Clinic, Yale New Haven Hospital, Anesthesiology

    Biography

    Dr. Carr received his anesthesiology training at the University of Medicine and Dentistry, Cooper University Hospital in the physician-scientist track. He proceeded to complete a critical care medicine fellowship at Dartmouth Hitchcock Medical Center and subsequently board certified in anesthesiology, critical care medicine and advanced perioperative transesophageal echocardiography. He joined the Yale University School of Medicine, Department of Anesthesiology in May of 2020.

    Last Updated on November 04, 2023.

    Appointments

    Other Departments & Organizations

    Education & Training

    Critical Care Fellow
    Dartmouth Hitchcock Medical Center (2014)
    Resident Physician
    University of Medicine & Dentistry of NJ, Cooper University Hospital (2010)
    MD
    University College Cork, National Univ. of Ireland, Medicine (2005)
    BSc (Hon)
    Rutgers University, Psychology (1999)

    Research

    Overview

    My current research interest is identification, quantification, and mitigation of perioperative complications. Shifting the paradigm of preoperative risk assessment to a precise, individualized and patient centered approach is one of my areas of research interest. In addition, I am interested in estimation and characterization of perioperative pulmonary complications, particularly in the care of previously neglected medical populations.

    Medical Research Interests

    Critical Care; Diseases; Lung Diseases, Interstitial; Perioperative Care; Perioperative Medicine; Postoperative Care

    Public Health Interests

    Antimicrobial Resistance; Bioinformatics; Cardiovascular Diseases; Emerging Infectious Diseases; Infectious Diseases; Pharmaceuticals and Medical Devices

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Zyad James Carr's published research.

    Publications

    Featured Publications

    2026

    2025

    • Preliminary insights into cardiopulmonary reserve and hemodynamic stability: exploring submaximal cardiopulmonary exercise testing parameters as potential predictors of intraoperative hemodynamic instability
      AUTHOR=Agarkov Daniel , Carr Zyad J. TITLE=Preliminary insights into cardiopulmonary reserve and hemodynamic stability: exploring submaximal cardiopulmonary exercise testing parameters as potential predictors of intraoperative hemodynamic instability JOURNAL=Frontiers in Anesthesiology VOLUME=Volume 4 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/anesthesiology/articles/10.3389/fanes.2025.1610632 DOI=10.3389/fanes.2025.1610632 ISSN=2813-480X ABSTRACT=BackgroundIntraoperative hypotension (IOH) is associated with serious adverse outcomes after noncardiac surgery. Preoperative predictors of IOH remain poorly characterized. Intraoperative hemodynamic instability is strongly associated with IOH. The authors hypothesized that submaximal cardiopulmonary exercise testing (smCPET) measures of forced vital capacity (FVC) and gas-exchange derived pulmonary capacitance to peak oxygen uptake slope (GXCAP-VO2) would be associated with two measures of intraoperative hemodynamic instability: intraoperative vasopressor use and systolic average real variability (ARV), respectively.MethodsThis secondary analysis of a feasibility study included adults >60 years undergoing elective noncardiac surgery and completed preoperative smCPET. Multiple cardiopulmonary measures, including FVC, peak oxygen uptake (VO2) and GXCAP-VO2 slope were collected. The primary outcome of intraoperative vasopressor use, and secondary outcome of ARV were tested with multivariable logistic regression and generalized linear models to assess associations supported by decision boundary and mediation analysis.ResultsAmong 101 participants, 54 had measured FVC (median 2.56 L) and 101 had measured GXCAP-VO2 slope (median 29.8). After adjustment, each standard deviation increase in FVC (0.89 L) was associated with halved odds of vasopressor use [2.47 L (SD 0.88) vs. 2.9 L (SD 0.86) adjusted Odds Ratio: 0.496 (95% CI: 0.25–1.01) p = 0.052]. Participants with FVC <2.18 L and surgery duration >152 min had the highest risk of vasopressor use. Systolic ARV was negatively associated with increasing surgical time (p < 0.001). For each 10-unit increase in GXCAP-VO2 slope, systolic ARV is expected to decrease by 9.8% [incidence rate ratio = 0.902, 95% CI (0.84, 0.97)].ConclusionLower measured FVC and GXCAP-VO2 slope were associated with measures of intraoperative hemodynamic instability in older adults undergoing noncardiac surgery. Preoperative assessment of pulmonary function and cardiopulmonary reserve may identify patients at higher risk for intraoperative hemodynamic instability. These exploratory observations establish a foundation for future research on smCPET measures for the prediction of perioperative complications, recognizing intraoperative hemodynamic instability as a complex interplay of patient, anesthetic, and surgical factors.
      Peer-Reviewed Original Research

    Academic Achievements & Community Involvement

    Activities

    • activity

      Society of Critical Care Anesthesiologists, Scientific Abstract Committee

    • activity

      Journal of Intensive Care Medicine

    • activity

      Drugs

    • activity

      Bioscience Reports

    • activity

      Clinical Interventions in Aging

    Honors

    • honor

      MSARF (medical student anesthesia research fellowship) mentor 2023

    • honor

      Fellow of the American Society of Anesthesiologists

    • honor

      Faculty Career Development Professorship in Anesthesiology

    • honor

      HCAHPS 99% Percentile, Patient Satisfaction Award

    • honor

      Junior Faculty Teaching Award 2016

    Clinical Care

    Overview

    Zyad James Carr, MD, is an anesthesiologist who specializes in critical care, helping patients navigate the challenges of surgery and recovery. He uses advanced methods to monitor vital functions, including breathing and circulation, for individuals who require high levels of support during and after procedures.

    As an associate professor of anesthesiology at Yale School of Medicine, Dr. Carr focuses his research on identifying, measuring, and reducing complications that can arise in the time around surgery. He seeks to customize risk assessment to the needs of each patient, especially those at greater risk for lung issues and other serious conditions.

    Dr. Carr completed his medical training at University College Cork, National University of Ireland. He pursued residency training in anesthesiology at the University of Medicine and Dentistry of New Jersey, Cooper University Hospital, followed by a fellowship in critical care medicine at Dartmouth Hitchcock Medical Center.

    Clinical Specialties

    Anesthesiology; Critical Care Anesthesiology

    Board Certifications

    • Anesthesiology

      Certification Organization
      AB of Anesthesiology
      Original Certification Date
      2011

    Get In Touch

    Contacts

    Mailing Address

    Anesthesiology

    333 Cedar Street, TMP-3

    New Haven, Connecticut 05610

    United States