Khaled Alok, MD, MBA
InstructorAbout
Research
Publications
2026
Diagnostic Pathways and Procedural Risk in Primary Central Nervous System Lymphoma: A Nationwide Analysis.
Qureshi K, Arakali S, Anzueto J, Huddleston D, Hobbs J, Saenz S, Thakkar R, Jayaram R, Goulart C, Alok K, Gupta M. Diagnostic Pathways and Procedural Risk in Primary Central Nervous System Lymphoma: A Nationwide Analysis. Acta Haematologica 2026, 1-11. PMID: 42081433, DOI: 10.1159/000552333.Peer-Reviewed Original ResearchPrimary central nervous system lymphomaCentral nervous system lymphomaNervous system lymphomaLumbar punctureBiopsy-onlyNeurosurgical biopsySystem lymphomaAdverse eventsPCNSL diagnosisDiagnosis of primary central nervous system lymphomaDiagnostic pathwayPrimary central nervous system lymphoma patientsPredictors of adverse eventsPost-procedural complicationsHigh-risk subgroupsMariner Claims DatabaseComplication rateThromboembolic eventsThromboembolic complicationsDiagnostic modalitiesProcedural complicationsAggressive malignancyClinical characteristicsBiopsy pathwayProcedural risk
2025
Long-term seizure and functional outcomes following peri-insular hemispherotomy
Moussa B, Alok K, Nawfal O, Najjar M, Farhat S, Beydoun A. Long-term seizure and functional outcomes following peri-insular hemispherotomy. Epilepsy & Behavior 2025, 173: 110801. PMID: 41175666, DOI: 10.1016/j.yebeh.2025.110801.Peer-Reviewed Original ResearchConceptsPeri-insular hemispherotomyLong-term seizureSeizure recurrenceFunctional outcomesEngel class I outcomePredictors of seizure recurrenceWada testAmerican University of Beirut Medical CenterContralateral seizure onsetLate seizure recurrenceClass I outcomeMiddle Eastern cohortSeizure-free yearsNo relapseEngel classificationIncomplete disconnectionPostoperative surveillanceSeizure outcomeEpileptiform dischargesSeizure freedomSurgical eligibilityUnilateral onsetFollow-upInterictal dischargesEastern cohortEvolving Treatment Paradigms of Meningiomas; a Precision Medicine Perspective
Galluzzo D, Chen C, Alok K, Moliterno J, Kurz S. Evolving Treatment Paradigms of Meningiomas; a Precision Medicine Perspective. Current Neurology And Neuroscience Reports 2025, 25: 69. PMID: 41085787, DOI: 10.1007/s11910-025-01461-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCentral nervous systemWHO classificationMedical managementDirection of targeted therapyWHO classification of tumorsCentral nervous system tumorsManagement of meningiomasMaximal safe resectionMultidisciplinary management strategyNervous system tumorsClassification of tumorsRadiotherapy strategiesSafe resectionSystemic therapyIntracranial meningiomasRecurrent casesTargeted therapyTumor typesSystem tumorsSurgical techniqueMolecular alterationsHigh-gradeClinical challengeMeningioma gradeMeningiomasIntraoperative neurovascular considerations for efficient intraventricular meningioma surgery: illustrative case
Alok K, Ocampo-Navia M, Yaşar B, Chavez M, Elsamadicy A, Moliterno J. Intraoperative neurovascular considerations for efficient intraventricular meningioma surgery: illustrative case. Journal Of Neurosurgery Case Lessons 2025, 9: case2569. PMID: 40523341, PMCID: PMC12171106, DOI: 10.3171/case2569.Peer-Reviewed Original ResearchIntraventricular meningiomasTumor devascularizationArterial feedersBrain retractionTemporary clippingGross-total tumor resectionProximity to critical neurovascular structuresTemporal horn entrapmentGross-total resectionTreatment of choiceSubtypes of brain tumorsCritical neurovascular structuresIntraoperative neurophysiological monitoringPreoperative embolizationIntraventricular tumorsTumor resectionVentricular obstructionBlood lossMeningioma surgerySurgical strategyTranssulcal approachNeurophysiological monitoringResectionIntracranial pressureTumor
2024
CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury
Li C, Ajmal E, Alok K, Powell K, Wadolowski S, Tambo W, Turpin J, Barthélemy E, Al-Abed Y, LeDoux D. CGRP as a potential mediator for the sexually dimorphic responses to traumatic brain injury. Biology Of Sex Differences 2024, 15: 44. PMID: 38816868, PMCID: PMC11138127, DOI: 10.1186/s13293-024-00619-x.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryChronic phase of traumatic brain injuryPhase of traumatic brain injuryTraumatic brain injury outcomesCalcitonin gene-related peptideBrain injuryDepression-like behaviorFemale ratsCalcitonin gene-related peptide inhibitionCalcitonin gene-related peptide expressionEndothelial nitric oxide synthaseOutcome of traumatic brain injuryBrain sub-regionsSexually dimorphic responseSevere traumatic brain injuryAnxiety-likeElevated levels of calcitonin gene-related peptideFemale sex hormonesSpatial memoryChronic phaseResultsFemale ratsNeuroprotective effectsCortical impactDimorphic responseBiological sexBioelectronic medicine in modulation of cortical spreading depolarization and beyond
Alok K, White T, Li C. Bioelectronic medicine in modulation of cortical spreading depolarization and beyond. Neural Regeneration Research 2024, 20: 481-482. PMID: 38819057, PMCID: PMC11317948, DOI: 10.4103/nrr.nrr-d-23-02059.Peer-Reviewed Original ResearchBrivaracetam-Associated Rhabdomyolysis Requiring Renal Replacement Therapy: A Case Report and Review of the Literature
Alok K, Lin A, Dematteo C, Abrar H, Levy Z. Brivaracetam-Associated Rhabdomyolysis Requiring Renal Replacement Therapy: A Case Report and Review of the Literature. Cureus 2024, 16: e58183. PMID: 38741805, PMCID: PMC11089833, DOI: 10.7759/cureus.58183.Peer-Reviewed Original ResearchFavorable adverse event profileSerum creatine kinase levelsCreatine kinase peakAdverse event profileSide effect profileCase of rhabdomyolysisCreatine kinase levelsRare adverse reactionLife-threatening rhabdomyolysisAssociation of rhabdomyolysisAdverse Event Reporting SystemSynaptic vesicle glycoprotein 2AEvent Reporting SystemEvent profileLevetiracetam useEffect profileCase reportAntiseizure medicationsKinase levelsAdverse reactionsRhabdomyolysisBrivaracetamLevetiracetamCurrent dataSV2ASuperficial Temporal Artery-to-Middle Cerebral Artery Bypass in Ischemic Stroke With Blood Pressure-Dependent Symptoms
Huang B, Huang C, Alok K, Chen A. Superficial Temporal Artery-to-Middle Cerebral Artery Bypass in Ischemic Stroke With Blood Pressure-Dependent Symptoms. Cureus 2024, 16: e56236. PMID: 38618338, PMCID: PMC11016294, DOI: 10.7759/cureus.56236.Peer-Reviewed Original ResearchSuperficial temporal artery-to-middle cerebral arteryEC-IC bypassSingle photon emission CTSuperficial temporal artery-to-middle cerebral artery bypassNational Institutes of Health Stroke ScaleMiddle cerebral arteryEC-ICTranscranial Doppler ultrasoundCT perfusionHemodynamic insufficiencyCerebral arteryPatient's National Institutes of Health Stroke ScaleCT perfusion imagingExtracranial-intracranial (EC-IC) bypassHealth Stroke ScaleArtery bypassNeurological deficitsEmission CTRight hemiparesisDoppler ultrasoundCore infarctIschemic stroke progressionStroke progressionIschemic penumbraCerebral flow
2022
Membranous obstruction of the foramen of magendie: A case report, literature review and recommendations
Habashy K, Houshiemy M, Alok K, Kawtharani S, Shehab H, Darwish H. Membranous obstruction of the foramen of magendie: A case report, literature review and recommendations. Interdisciplinary Neurosurgery 2022, 27: 101414. DOI: 10.1016/j.inat.2021.101414.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsFourth ventricleEnlarged fourth ventricleVentricle outlet obstructionForamen of MagendieCerebrospinal fluid dynamicsMembranous obstructionOutlet obstructionTetraventricular hydrocephalusCongenital malformationsTreatment algorithmCase reportChronic headacheCerebral ventricleInflammatory processDiagnostic approachVentricleGait disturbanceAdult womenHydrocephalusFVOOObstructionForamenLiterature reviewTreatment
2021
Antenatally diagnosed intraspinal-posterior mediastinal neurenteric cyst - what is the optimal management?
Bejjani N, Andraos R, Alok K, Akel S, Najjar M. Antenatally diagnosed intraspinal-posterior mediastinal neurenteric cyst - what is the optimal management? Clinical Neurology And Neurosurgery 2021, 212: 107040. PMID: 34844160, DOI: 10.1016/j.clineuro.2021.107040.Peer-Reviewed Original ResearchConceptsMediastinal neurenteric cystNeurenteric cystRecurrent episodesRecurrent episodes of bacterial meningitisTwo-stage surgical resectionEpisodes of bacterial meningitisImage-guided aspirationAntenatal ultrasoundSurgical resectionAntenatal diagnosisCongenital anomaliesBacterial meningitisEarly infancyAdult presentationOptimal managementCystsLate childhoodAspirationManagement algorithmIntrauterineResectionMeningitisAntenatalExcisionPatients
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Yale School of Medicine
Department of Neurosurgery, 310 Cedar St.
New Haven, CT 06520
United States