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    Daniel P. Petrylak, MD

    Professor of Medicine (Medical Oncology) and of Urology
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    Additional Titles

    Chief, Genitourinary Oncology

    About

    Titles

    Professor of Medicine (Medical Oncology) and of Urology

    Chief, Genitourinary Oncology

    Biography

    As Professor of Medicine and Urology at Yale School of Medicine, Dr. Daniel P. Petrylak is a pioneer in the research and development of new drugs and treatments to fight prostate, bladder, kidney and testicular cancer. For patients fighting these types of cancers, Petrylak finds recent developments in the field of immunotherapy particularly promising. “Up until recently, bladder cancer had not seen any major advancement in more than 30 years,” he says. “Studies are ongoing, but interim results are exciting so far.”

    At the Smilow Cancer Hospital, Dr. Petrylak’s position as a national leader on clinical trials for men with prostate and bladder cancer has opened up a world of treatment options for patients in New England. “We offer the latest investigational drugs for these conditions, while providing the highest level of care,” he says.

    Dr. Petrylak received his MD from Case Western Reserve University School of Medicine and joined the Yale faculty in 2012. In addition to his role as professor, he is also a member of the Cancer Signaling Networks Research Program at Yale Cancer Center, which studies how cancer stem cells are regulated in the body and communicate with surrounding tissue. Roughly 40 physicians and scientists in the program work together to develop the best methods for matching patients with the appropriate cancer drugs.

    One of Dr. Petrylak’s key goals is to continue to successfully translate basic research into clinical practice. “One of the most significant accomplishments in my career was moving docetaxel (an antineoplastic agent) therapy for the most advanced form of prostate cancer from phase I to III,” he says. “We ran a trial which supported its approval for the most advanced form of prostate cancer.”

    Dr. Petrylak currently serves as either the principal investigator or co-principal investigator on seven Southwest Oncology Group (SWOG) clinical trials for genitourinary cancers. To date, he has authored more than 100 peer-reviewed articles on prostate and bladder cancer research.

    Appointments

    • Medical Oncology

      Professor
      Primary

    • Urology

      Professor
      Secondary

    Other Departments & Organizations

    Education & Training

    Fellowship
    Memorial Sloan-Kettering Cancer Center (1991)
    Residency
    Bronx Municipal Hospital (1988)
    Internship
    Bronx Municipal Hospital (1986)
    MD
    Case Western Reserve University School of Medicine (1985)

    Research

    Overview

    Medical Research Interests

    Clinical Trial; Medical Oncology; Prostatic Neoplasms; Signal Transduction; Urinary Bladder Neoplasms; Urology

    Research at a Glance

    Yale Co-Authors

    Frequent collaborators of Daniel P. Petrylak's published research.

    Publications

    2024

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    Clinical Trials

    Current Trials

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    Clinical Care

    Overview

    As Professor of Medicine and Urology at Yale School of Medicine, Dr. Daniel P. Petrylak is a pioneer in the research and development of new drugs and treatments to fight prostate, bladder, kidney and testicular cancer. For patients fighting these types of cancers, Petrylak finds recent developments in the field of immunotherapy particularly promising. “Up until recently, bladder cancer had not seen any major advancement in more than 30 years,” he says. “Studies are ongoing, but interim results are exciting so far.”

    At the Smilow Cancer Hospital, Dr. Petrylak’s position as a national leader on clinical trials for men with prostate and bladder cancer has opened up a world of treatment options for patients in New England. “We offer the latest investigational drugs for these conditions, while providing the highest level of care,” he says.

    Dr. Petrylak received his MD from Case Western Reserve University School of Medicine and joined the Yale faculty in 2012. In addition to his role as professor, he is also the co-director of the Signal Transduction Research Program at Yale Cancer Center, which studies how cancer stem cells are regulated in the body and communicate with surrounding tissue. Roughly 40 physicians and scientists in the program work together to develop the best methods for matching patients with the appropriate cancer drugs.

    One of Dr. Petrylak’s key goals is to continue to successfully translate basic research into clinical practice. “One of the most significant accomplishments in my career was moving docetaxel (an antineoplastic agent) therapy for the most advanced form of prostate cancer from phase I to III,” he says. “We ran a trial which supported its approval for the most advanced form of prostate cancer.”

    Dr. Petrylak currently serves as either the principal investigator or co-principal investigator on seven Southwest Oncology Group (SWOG) clinical trials for genitourinary cancers. To date, he has authored more than 100 peer-reviewed articles on prostate and bladder cancer research.

    Clinical Specialties

    Medical Oncology; Urology

    Fact Sheets

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    Board Certifications

    • Medical Oncology

      Certification Organization
      AB of Internal Medicine
      Latest Certification Date
      2023
      Original Certification Date
      1993

    Yale Medicine News

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    Contacts

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    Clinic Fax Number

    Locations

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