Chunxiang Wu
Associate Research ScientistAbout
Research
Publications
2026
Structural basis of TACO1-mediated efficient mitochondrial translation
Wang S, Brischigliaro M, Zhang Y, Wu C, Zheng W, Barrientos A, Xiong Y. Structural basis of TACO1-mediated efficient mitochondrial translation. Nature Communications 2026, 17: 2521. PMID: 41663403, PMCID: PMC12996406, DOI: 10.1038/s41467-026-69156-y.Peer-Reviewed Original ResearchOligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in Salmonella Typhimurium
Wang T, Zhu L, Guo E, Wu C, Schueder F, Lara-Tejero M, Galán J. Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in Salmonella Typhimurium. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2530441123. PMID: 41587314, PMCID: PMC12878844, DOI: 10.1073/pnas.2530441123.Peer-Reviewed Original Research
2025
Distinct Target Site of Lenacapavir in Immature HIV‑1 and Concurrent Binding with the Maturation Inhibitor Bevirimat
Wu C, Meuser M, Rey J, Meshkin H, Yang R, Devarkar S, Freniere C, Shi J, Aiken C, Perilla J, Xiong Y. Distinct Target Site of Lenacapavir in Immature HIV‑1 and Concurrent Binding with the Maturation Inhibitor Bevirimat. Journal Of The American Chemical Society 2025, 147: 42685-42700. PMID: 41198571, PMCID: PMC12900427, DOI: 10.1021/jacs.5c13735.Peer-Reviewed Original ResearchExploring the Structural Divergence of HIV and SRLV Lentiviral Capsids
Arizaga F, Freniere C, Rey J, Cook M, Wu C, Perilla J, Xiong Y. Exploring the Structural Divergence of HIV and SRLV Lentiviral Capsids. Journal Of The American Chemical Society 2025, 147: 32883-32895. PMID: 40878534, PMCID: PMC12515838, DOI: 10.1021/jacs.5c09436.Peer-Reviewed Original ResearchStructural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM
Cook M, Freniere C, Wu C, Lozano F, Xiong Y. Structural insights into HIV-2 CA lattice formation and FG-pocket binding revealed by single-particle cryo-EM. Cell Reports 2025, 44: 115245. PMID: 39864060, PMCID: PMC11912512, DOI: 10.1016/j.celrep.2025.115245.Peer-Reviewed Original Research
2024
Channel width modulates the permeability of DNA origami–based nuclear pore mimics
Feng Q, Saladin M, Wu C, Cao E, Zheng W, Zhang A, Bhardwaj P, Li X, Shen Q, Kapinos L, Kozai T, Mariappan M, Lusk C, Xiong Y, Lim R, Lin C. Channel width modulates the permeability of DNA origami–based nuclear pore mimics. Science Advances 2024, 10: eadq8773. PMID: 39536094, PMCID: PMC11559598, DOI: 10.1126/sciadv.adq8773.Peer-Reviewed Original ResearchStructural insights into PPP2R5A degradation by HIV-1 Vif
Hu Y, Delviks-Frankenberry K, Wu C, Arizaga F, Pathak V, Xiong Y. Structural insights into PPP2R5A degradation by HIV-1 Vif. Nature Structural & Molecular Biology 2024, 31: 1492-1501. PMID: 38789685, PMCID: PMC12221852, DOI: 10.1038/s41594-024-01314-6.Peer-Reviewed Original Research
2023
Abl2 repairs microtubules and phase separates with tubulin to promote microtubule nucleation
Duan D, Lyu W, Chai P, Ma S, Wu K, Wu C, Xiong Y, Sestan N, Zhang K, Koleske A. Abl2 repairs microtubules and phase separates with tubulin to promote microtubule nucleation. Current Biology 2023, 33: 4582-4598.e10. PMID: 37858340, PMCID: PMC10877310, DOI: 10.1016/j.cub.2023.09.018.Peer-Reviewed Original ResearchThe capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores
Shen Q, Kumari S, Xu C, Jang S, Shi J, Burdick R, Levintov L, Xiong Q, Wu C, Devarkar S, Tian T, Tripler T, Hu Y, Yuan S, Temple J, Feng Q, Lusk C, Aiken C, Engelman A, Perilla J, Pathak V, Lin C, Xiong Y. The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2202815120. PMID: 36943880, PMCID: PMC10068764, DOI: 10.1073/pnas.2202815120.Peer-Reviewed Original ResearchEnrich and switch: IP6 and maturation of HIV-1 capsid
Wu C, Xiong Y. Enrich and switch: IP6 and maturation of HIV-1 capsid. Nature Structural & Molecular Biology 2023, 30: 239-241. PMID: 36849641, PMCID: PMC10033439, DOI: 10.1038/s41594-023-00940-w.Peer-Reviewed Original Research