Chin Siang Ong, MBBS, PhD, MPH
Assistant Professor of Surgery (Surgical Outcomes)Cards
About
Research
Publications
2026
BPI26-028: Hippocrates-Karkinos-o1: An Enhanced Model for Oncology Decision Support and Guideline-Aware Reasoning With Self-Refinement and Guideline-Informed Retrieval.
Aguirre N, Wang B, Schaefer E, Huang J, Li X, Kolamuri S, Ying L, Li X, Ang S, Schneider E, Pai S, Cohan A, Ong C. BPI26-028: Hippocrates-Karkinos-o1: An Enhanced Model for Oncology Decision Support and Guideline-Aware Reasoning With Self-Refinement and Guideline-Informed Retrieval. Journal Of The National Comprehensive Cancer Network 2026, 24 PMID: 42061427, DOI: 10.6004/jnccn.2025.7253.Peer-Reviewed Original ResearchGenome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve
Thériault S, Holdcraft J, Sharipova D, Faucherre A, Debiec R, Peloso G, Al-Kassou B, Aranki S, Swan E, Ballotta A, Bellino M, Björck H, Boureau A, Braund P, Corriveau F, Dagenais F, Folkersen L, Forte A, Francke M, Frigiola A, Gorbatov S, Guo D, Habchi K, Heydarpour M, Isselbacher E, Jopling C, Laporte F, Le Scouarnec S, Li Z, Lichtner P, Maj C, Manikpurage H, Nelson C, Nguyen T, Norris R, Ong C, Pibarot P, Roychowdhury T, Sarubbi B, Simonet F, Sundt T, Surakka I, Tessler I, Willer C, Wittmann S, Yang B, Berezovets I, Doppler S, Dreßen M, Knoll K, Puehler T, Schunkert H, Avierinos J, Bissell M, Bolger A, Bossé Y, Bossone E, Brion M, Citro R, de Vincentiis C, Deeb G, Della Corte A, Dina C, Durst R, Ensminger S, Eriksson P, Evangelista A, Franco-Cereceda A, Gilon D, Giusti B, Hetherington S, Huggins G, Krane M, Le Tourneau T, Limongelli G, Mathieu P, Messika-Zeitoun D, Michelena H, Milewicz D, Muehlschlegel J, Murdock D, Nickenig G, Nistri S, Nöthen M, Pluchinotta F, Prakash S, Samani N, Schott J, Webb T, Zaffran S, Abdelilah-Seyfried S, Eagle K, Schumacher J, Trenkwalder T, Body S. Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve. Circulation 2026, 153: 1060-1076. PMID: 41645906, PMCID: PMC13001617, DOI: 10.1161/circulationaha.125.074752.Peer-Reviewed Original Research
2025
Instruction-Tuned Large Language Models for Clinical Data Extraction: Creating an Aortic Measurement Database from CT Radiology Reports
Erez E, Dankwa S, Tuttle M, Nasir A, Vallabhajosyula P, Schneider E, Assi R, Ong C. Instruction-Tuned Large Language Models for Clinical Data Extraction: Creating an Aortic Measurement Database from CT Radiology Reports. Journal Of Healthcare Informatics Research 2025, 9: 587-605. PMID: 41230242, PMCID: PMC12602774, DOI: 10.1007/s41666-025-00210-y.Peer-Reviewed Original ResearchLung adenocarcinoma-derived IFN-γ promotes growth by modulating CD8+ T cell production of CCR5 chemokines
Kratzmeier C, Taheri M, Mei Z, Lim I, Khalil M, Carter-Cooper B, Fanaroff R, Ong C, Schneider E, Chang S, Leyder E, Li D, Luzina I, Banerjee A, Krupnick A. Lung adenocarcinoma-derived IFN-γ promotes growth by modulating CD8+ T cell production of CCR5 chemokines. Journal Of Clinical Investigation 2025, 135: e191070. PMID: 40553564, PMCID: PMC12404755, DOI: 10.1172/jci191070.Peer-Reviewed Original Research
2024
SurgeryLLM: a retrieval-augmented generation large language model framework for surgical decision support and workflow enhancement
Ong C, Obey N, Zheng Y, Cohan A, Schneider E. SurgeryLLM: a retrieval-augmented generation large language model framework for surgical decision support and workflow enhancement. Npj Digital Medicine 2024, 7: 364. PMID: 39695316, PMCID: PMC11655968, DOI: 10.1038/s41746-024-01391-3.Peer-Reviewed Original Research
2023
Emergent Applications of Machine Learning for Diagnosing and Managing Appendicitis: A State-of-the-Art Review
Bhandarkar S, Tsutsumi A, Schneider E, Ong C, Paredes L, Brackett A, Ahuja V. Emergent Applications of Machine Learning for Diagnosing and Managing Appendicitis: A State-of-the-Art Review. Surgical Infections 2023, 25: 7-18. PMID: 38150507, DOI: 10.1089/sur.2023.201.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsImpact of intraoperative blood products, fluid administration, and persistent hypothermia on bleeding leading to reexploration after cardiac surgery
Shou B, Zhou A, Ong C, Alejo D, DiNatale J, Larson E, Lawton J, Schena S. Impact of intraoperative blood products, fluid administration, and persistent hypothermia on bleeding leading to reexploration after cardiac surgery. Journal Of Thoracic And Cardiovascular Surgery 2023, 168: 873-884.e4. PMID: 37839660, DOI: 10.1016/j.jtcvs.2023.10.011.Peer-Reviewed Original ResearchEffect of concurrent mitral valve surgery for secondary mitral regurgitation upon mortality after aortic valve replacement or coronary artery bypass surgery
Asher S, Ong C, Malapero R, Heydarpour M, Malzberg G, Shahram J, Nguyen T, Shook D, Shernan S, Shekar P, Kaneko T, Citro R, Muehlschlegel J, Body S. Effect of concurrent mitral valve surgery for secondary mitral regurgitation upon mortality after aortic valve replacement or coronary artery bypass surgery. Frontiers In Cardiovascular Medicine 2023, 10: 1202174. PMID: 37840960, PMCID: PMC10570832, DOI: 10.3389/fcvm.2023.1202174.Peer-Reviewed Original ResearchHistorical Accounts of Congenital Heart Surgery
Mavroudis C, Ong C, Vricella L, Cameron D. Historical Accounts of Congenital Heart Surgery. World Journal For Pediatric And Congenital Heart Surgery 2023, 14: 626-641. PMID: 37737603, DOI: 10.1177/21501351231186415.Peer-Reviewed Original ResearchRecruited macrophages elicit atrial fibrillation
Hulsmans M, Schloss M, Lee I, Bapat A, Iwamoto Y, Vinegoni C, Paccalet A, Yamazoe M, Grune J, Pabel S, Momin N, Seung H, Kumowski N, Pulous F, Keller D, Bening C, Green U, Lennerz J, Mitchell R, Lewis A, Casadei B, Iborra-Egea O, Bayes-Genis A, Sossalla S, Ong C, Pierson R, Aster J, Rohde D, Wojtkiewicz G, Weissleder R, Swirski F, Tellides G, Tolis G, Melnitchouk S, Milan D, Ellinor P, Naxerova K, Nahrendorf M. Recruited macrophages elicit atrial fibrillation. Science 2023, 381: 231-239. PMID: 37440641, PMCID: PMC10448807, DOI: 10.1126/science.abq3061.Peer-Reviewed Original Research