Stacy Malaker
Associate Professor TenureCards
About
Research
Publications
2026
O‑Glycosylation Shapes the Proteolytic Landscape of the Native Tear Peptidome
Chang V, Chen R, Lian I, Mahoney K, Malaker S. O‑Glycosylation Shapes the Proteolytic Landscape of the Native Tear Peptidome. JACS Au 2026 DOI: 10.1021/jacsau.6c00834.Peer-Reviewed Original ResearchMapping galectin-3 ligands in human tear fluid establishes spliceoform-dependent lacritin binding
Chang V, Lian I, Mahoney K, Romano J, Afshari A, Chen R, Chen X, Fineide F, Khan A, Utheim T, Karlsson N, Laurie G, Malaker S. Mapping galectin-3 ligands in human tear fluid establishes spliceoform-dependent lacritin binding. Communications Biology 2026 PMID: 42191868, DOI: 10.1038/s42003-026-10337-2.Peer-Reviewed Original ResearchGlycosite mapping and in situ mass spectrometry imaging of MUC2 glycopeptides via on-slide mucinase digestion
Lowery S, Ribi M, Chongsaritsinsuk J, Tran I, Grimsley G, Stubler R, Mahoney K, Lucas T, Charkoftaki G, Santos-Neto A, Varki N, Vasiliou V, Angelo M, Drake R, Malaker S. Glycosite mapping and in situ mass spectrometry imaging of MUC2 glycopeptides via on-slide mucinase digestion. Nature Communications 2026 PMID: 42098121, DOI: 10.1038/s41467-026-72853-3.Peer-Reviewed Original ResearchScreening of the transcriptome, mucinome, and O‐/N‐glycans of the intestinal goblet cell model HT29‐MTX during zinc deficiency
Schüßler C, Chung N, Leonard R, Sprenger H, Braeuning A, Morelle W, Foulquier F, Malaker S, Masselot C, Maares M. Screening of the transcriptome, mucinome, and O‐/N‐glycans of the intestinal goblet cell model HT29‐MTX during zinc deficiency. Lebensmittelchemie 2026, 80: s1-113-s1-113. DOI: 10.1002/lemi.202651077.Peer-Reviewed Original ResearchImpaired glycosylation promotes rapid transition to hepatocellular carcinoma in model of diet induced steatotic liver disease
Singh A, Chaube B, Citrin K, Fowler J, Lee S, Catarino J, Knight J, Lowery S, Shree S, Mahoney K, Boutagy N, Ruz-Maldonado I, Harry K, Shanabrough M, Ross T, Malaker S, Suárez Y, Fernández-Hernando C, Grabińska K, Sessa W. Impaired glycosylation promotes rapid transition to hepatocellular carcinoma in model of diet induced steatotic liver disease. Journal Of Clinical Investigation 2026, 136: e197719. PMID: 41805633, PMCID: PMC13132402, DOI: 10.1172/jci197719.Peer-Reviewed Original ResearchXylosyltransferase engineering to manipulate proteoglycans in mammalian cells
Li Z, Chawla H, Di Vagno L, Ní Cheallaigh A, Critcher M, Sammon D, Gonzalez-Rodriguez E, Briggs D, Chung N, Chang V, Mahoney K, Cioce A, Bineva-Todd G, Wang P, Liu Y, Murphy L, Chen Y, Narimatsu Y, Miller R, Willems L, Malaker S, Huang M, Miller G, Hohenester E, Schumann B. Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells. Nature Chemical Biology 2026, 22: 612-621. PMID: 41559400, PMCID: PMC13038410, DOI: 10.1038/s41589-025-02113-w.Peer-Reviewed Original ResearchErratum: Decoding Extracellular Protein Glycosylation in Human Health and Disease
Steigmeyer A, Lowery S, Rangel-Angarita V, Malaker S. Erratum: Decoding Extracellular Protein Glycosylation in Human Health and Disease. Annual Review Of Analytical Chemistry 2026 DOI: 10.1146/annurev-ac-18-010726-200001.Commentaries, Editorials and LettersEnrichment strategies for mucin-domain O-glycoproteins
Finn S, Malaker S. Enrichment strategies for mucin-domain O-glycoproteins. Methods In Enzymology 2026 DOI: 10.1016/bs.mie.2026.03.003.BooksCharacterization of O-glycoproteases for applications in mass spectrometry
Steigmeyer A, Chongsaritsinsuk J, Malaker S. Characterization of O-glycoproteases for applications in mass spectrometry. Methods In Enzymology 2026 DOI: 10.1016/bs.mie.2026.03.004.Books
2025
An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function
Jame-Chenarboo Z, Schmidt E, Crichton M, Takahashi-Yamashiro K, Lima G, Luna-Dulcey L, Jung J, Ivison S, St. Laurent C, Enterina J, Lin S, Sarkar S, Joe M, Mozaneh F, John R, Nanjappa S, Malaker S, Levings M, Marth J, Derda R, Macauley M. An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function. Science Advances 2025, 11: eadz8096. PMID: 41223255, PMCID: PMC12609110, DOI: 10.1126/sciadv.adz8096.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
News
- July 17, 2026
Women’s Health Research at Yale Funds Projects on Obesity and Ovarian Aging, Diabetes, Cancers, and Autoimmunity
- October 17, 2025
Results Realized: Better Understanding the Structure of CA125
- September 08, 2023
WHRY Launches New Pilot Project Studies
- May 25, 2023Source: NBC CT
Yale Researcher Studying How to Detect Ovarian Cancer Earlier