Zachary E. Williams
Hospital ResidentCards
About
Research
Publications
2026
Topical delivery of a PPARγ agonist enables adipogenic repair of irradiated skin.
Siegel A, Hanumantharao S, Koirala P, Sehgal V, He C, Wu M, Ali Akbari Ghavimi S, Chen Z, Williams Z, Xu X, Liu C, Kozono D, Agarwal S. Topical delivery of a PPARγ agonist enables adipogenic repair of irradiated skin. Mol Ther Adv 2026, 34: 201732. PMID: 42211743, DOI: 10.1016/j.omta.2026.201732.Peer-Reviewed Original ResearchInnovative wound management of refractory venous ulcers with topical oxygen therapy
Williams Z, Singh I, Marks N, Ascher E, Hingorani A. Innovative wound management of refractory venous ulcers with topical oxygen therapy. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2026, 14: 102487. PMID: 41864536, PMCID: PMC13092594, DOI: 10.1016/j.jvsv.2026.102487.Peer-Reviewed Original ResearchTopical oxygen therapySingle-center retrospective reviewVenous leg ulcersOxygen therapyRefractory venous ulcersUlcer lengthUlcer widthUlcer durationRetrospective review of treatment outcomesVenous ulcersRefractory venous leg ulcersReview of treatment outcomesIliac vein stentingRandomized prospective trialAverage durationHistory of smokingMean treatment lengthProspective trialsVein stentingMedian timeWound managementGranulation tissue formationTreatment outcomesTherapyAlternative therapiesActivation of PPARγ redirects fibro-adipogenic progenitors to replace ectopic bone with fat in models of fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification.
Koirala P, Chen Z, Hanumantharao SN, Siegel AE, Liu C, Williams Z, Sekhon H, Maridas D, Mishina Y, Rosen V, Agarwal S. Activation of PPARγ redirects fibro-adipogenic progenitors to replace ectopic bone with fat in models of fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification. BioRxiv 2026 PMID: 41852699, DOI: 10.64898/2026.02.26.708276.Peer-Reviewed Original ResearchInfrainguinal bypass with alternative conduits in diabetic patients with chronic limb-threatening ischemia
Williams Z, Pinto-Rodriguez P, Zwibelman H, Strosberg D, Aboian E, Tonnessen B, Ochoa Chaar C, Cardella J. Infrainguinal bypass with alternative conduits in diabetic patients with chronic limb-threatening ischemia. Journal Of Vascular Surgery 2026, 83: 1553-1565. PMID: 41654038, DOI: 10.1016/j.jvs.2026.01.037.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaGreat saphenous veinGreat saphenous vein groupsDiabetes mellitusAmputation-free survivalInfrainguinal bypassLimb-threatening ischemiaAlternative conduitVascular Quality Initiative databaseRates of amputation-free survivalLong-term freedomOutcomes of patientsKaplan-Meier analysisAmputation-free survival rateAutologous great saphenous veinVascular Quality InitiativeAcceptable limb salvageAdverse limb eventsMultivariate regression analysisPerioperative mortalityInferior outcomesSurgical revascularizationBaseline characteristicsGraft occlusionKaplan-Meier
2025
ASO Visual Abstract: Risk of Malignancy for Indeterminate Cytology of Bile Duct Strictures: A Systematic Review and Meta-analysis
Lieb K, Williams Z, Sayles H, Zaman M, Dhir M. ASO Visual Abstract: Risk of Malignancy for Indeterminate Cytology of Bile Duct Strictures: A Systematic Review and Meta-analysis. Annals Of Surgical Oncology 2025, 32: 5735-5736. DOI: 10.1245/s10434-025-17474-8.Peer-Reviewed Original ResearchRisk of Malignancy for Indeterminate Cytology of Bile Duct Strictures: A Systematic Review and Meta-analysis
Lieb K, Williams Z, Sayles H, Zaman M, Dhir M. Risk of Malignancy for Indeterminate Cytology of Bile Duct Strictures: A Systematic Review and Meta-analysis. Annals Of Surgical Oncology 2025, 32: 5657-5666. PMID: 40272671, DOI: 10.1245/s10434-025-17292-y.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBile duct strictureRisk of malignancyIndeterminate cytologyBrush cytologyDuct stricturesPreoperative counselingPreoperative counseling of patientsBile duct cytologyEndoscopic brush cytologyDatabase inceptionPreoperative patient counselingCounseling of patientsMethodsA comprehensive searchSystematic reviewDuct cytologyAtypical cytologySuspicious cytologyMalignancy rateMalignancy riskBiliary stricturesEndoscopic samplesMalignancyCytologyPatient counselingStricture
2024
Endovascular Repair of Primary Aortocaval Fistula at the Caval Confluence in a Ruptured Abdominal Aortic Aneurysm
Williams Z, Choudhry A, Rahman N, Chihade D, Surowiec S. Endovascular Repair of Primary Aortocaval Fistula at the Caval Confluence in a Ruptured Abdominal Aortic Aneurysm. Vascular And Endovascular Surgery 2024, 59: 420-423. PMID: 39526864, DOI: 10.1177/15385744241300780.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPrimary aortocaval fistulaAortocaval fistulaCaval confluenceRare presentationEndovascular repairRuptured abdominal aortic aneurysmResults:Open surgical interventionAbdominal aortic aneurysmEndovascular exclusionAnatomical challengesSurgical interventionAortic aneurysmRuptured AAATreatment optionsFistulaClinical signsCavalEndovascularComplicationsConclusions:AneurysmGraftMortalityIncidence of Compartment Syndrome Following Peri-Pandemic Intervention for Non-traumatic Acute Limb Ischemia
Chihade D, Williams Z, Wainwright B, Shaw P. Incidence of Compartment Syndrome Following Peri-Pandemic Intervention for Non-traumatic Acute Limb Ischemia. Vascular And Endovascular Surgery 2024, 59: 360-366. PMID: 39436212, DOI: 10.1177/15385744241296217.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedAged, 80 and overAmputation, SurgicalComorbidityCompartment SyndromesCOVID-19Databases, FactualEndovascular ProceduresFemaleHumansIncidenceIschemiaLimb SalvageMaleMiddle AgedPeripheral Arterial DiseaseRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeVascular Surgical ProceduresConceptsAcute limb ischemiaAcute limb ischemia patientsCompartment syndromeCS patientsCS diagnosisRe-interventionConclusionsThe incidenceAdverse outcomesLimb ischemiaNon-CS cohortRates of adverse outcomesRisk of adverse outcomesIncidence of compartment syndromeIncidence of CSPrevalence of comorbiditiesPeripheral vascular diseasePre-pandemic ratesCS incidenceMajor amputationPre-pandemic cohortERAS cohortPeri-pandemicNon-CPatientsVascular diseaseEndovascular salvage of occluded renal artery after >15 hours of ischemic time
Williams Z, DeNoble D, Rahman N, Choudhry A, Feghali A. Endovascular salvage of occluded renal artery after >15 hours of ischemic time. Journal Of Vascular Surgery Cases And Innovative Techniques 2024, 10: 101511. PMID: 38799651, PMCID: PMC11127550, DOI: 10.1016/j.jvscit.2024.101511.Peer-Reviewed Original ResearchEndovascular salvageIschemic timeSevere casesRenal artery occlusionIrreversible ischemic damageAcute kidney injuryPercutaneous endovascular stentingLong-term sequelaeWarm ischemic timeAll-terrain vehicle accidentAcute traumatic injuryRenal salvageCreatinine levelsYounger patientsKidney injuryRenal arteryRenal parenchymaArtery occlusionEndovascular stentingVascular surgeryPatient's kidneyIschemic damageOutside hospitalYounger ageTraumatic injury
2023
Giant isolated profunda femoris artery aneurysm treated with aneurysmal ligation without profunda femoris artery revascularization
Rahman N, Williams Z, Choudhry A, Surowiec S. Giant isolated profunda femoris artery aneurysm treated with aneurysmal ligation without profunda femoris artery revascularization. Journal Of Vascular Surgery Cases And Innovative Techniques 2023, 9: 101328. PMID: 37953974, PMCID: PMC10632769, DOI: 10.1016/j.jvscit.2023.101328.Peer-Reviewed Original ResearchProfunda femoris artery aneurysmAneurysm ligationProfunda femoris arteryComputed tomography angiographyEndovascular coil embolizationPotential surgical optionsSuperficial femoral arterySurgical optionsCoil embolizationRight groinPulsatile massArtery revascularizationInterposition graftPopliteal aneurysmsAneurysmFemoral arteryLigationRevascularizationArtery