Ryan Kramer, MD
Hospital ResidentCards
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Research
Publications
2024
Advances in Detecting, Prognosticating, and Treating Hepatocellular Carcinoma: Advances and Outcomes
Kramer R, Moris D. Advances in Detecting, Prognosticating, and Treating Hepatocellular Carcinoma: Advances and Outcomes. Cancers 2024, 16: 2165. PMID: 38927871, PMCID: PMC11201984, DOI: 10.3390/cancers16122165.Peer-Reviewed Original ResearchUnsupervised clustering using multiple correspondence analysis reveals clinically-relevant demographic variables across multiple gastrointestinal cancers
Kramer R, Rhodin K, Therien A, Raman V, Eckhoff A, Thompson C, Tong B, Blazer D, Lidsky M, D’Amico T, Nussbaum D. Unsupervised clustering using multiple correspondence analysis reveals clinically-relevant demographic variables across multiple gastrointestinal cancers. Surgical Oncology Insight 2024, 1: 100009. DOI: 10.1016/j.soi.2024.100009.Peer-Reviewed Original ResearchAssociation of Somatic TET2 Mutations With Giant Cell Arteritis
Robinette M, Weeks L, Kramer R, Agrawal M, Gibson C, Yu Z, Sekar A, Mehta A, Niroula A, Brown J, McDermott G, Reshef E, Lu J, Liou V, Chiou C, Natarajan P, Freitag S, Rao D, Ebert B. Association of Somatic TET2 Mutations With Giant Cell Arteritis. Arthritis & Rheumatology 2024, 76: 438-443. PMID: 37909388, PMCID: PMC10922498, DOI: 10.1002/art.42738.Peer-Reviewed Original ResearchConceptsGiant cell arteritisClonal hematopoiesisHematologic malignanciesTET2 mutationsVision lossSomatic TET2 mutationsClinical phenotypes of giant cell arteritisDevelopment of giant cell arteritisGiant cell arteritis diagnosisAssociated with vision lossSomatic mutationsPresence of somatic mutationsIncident giant cell arteritisDevelopment of hematological malignanciesUKB participantsInfluence clinical outcomesMultivariate Cox regressionSomatic genetic testingPresence of mutationsElectronic health record reviewHealth record reviewUK Biobank (UKBGCA cohortClinical outcomesClonal mutationsSimple versus radical cholecystectomy and survival for pathologic stage T1B gallbladder cancer
Rhodin K, Goins S, Kramer R, Eckhoff A, Herbert G, Shah K, Allen P, Nussbaum D, Blazer D, Zani S, Lidsky M. Simple versus radical cholecystectomy and survival for pathologic stage T1B gallbladder cancer. Hepato Pancreato Biliary 2024, 26: 594-602. PMID: 38336604, DOI: 10.1016/j.hpb.2024.01.012.Peer-Reviewed Original Research
2023
Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-β Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice
Sun B, Rouzbehani O, Kramer R, Ghosh R, Perelli R, Atkins S, Fatahian A, Davis K, Szulik M, Goodman M, Hathaway M, Chi E, Word T, Tunuguntla H, Denfield S, Wehrens X, Whitehead K, Abdelnasser H, Warren J, Wu M, Franklin S, Boudina S, Landstrom A. Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-β Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice. Circulation Heart Failure 2023, 16: e010351. PMID: 38113297, PMCID: PMC10752244, DOI: 10.1161/circheartfailure.122.010351.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCardiomyopathiesCardiomyopathy, DilatedCell ProliferationCells, CulturedChild, PreschoolDNA-Binding ProteinsFemaleGene Knock-In TechniquesHeart FailureHumansInfant, NewbornIsolated Noncompaction of the Ventricular MyocardiumMaleMiceMyocardiumMyocytes, CardiacSignal TransductionTransforming Growth Factor betaConceptsInduced pluripotent stem cell-derived cardiomyocytesLeft ventricular noncompaction cardiomyopathyPluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesVentricular noncompaction cardiomyopathyNoncompaction cardiomyopathyCell-derived cardiomyocytesTGF-b signalingMyocardial developmentTGF-bCardiomyopathy developmentTGF-b expressionLoss-of-function variantsKnock-in mouse modelTranscriptional dysregulation of genesStatistically significant impairmentIn vitro modelAge-dependent lossDysregulation of genesMyocyte proliferationVentricular dimensionsHeart failureCardiac maturationCardiomyopathyMouse modelPRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study
Kramer R, Fatahian A, Chan A, Mortenson J, Osher J, Sun B, Parker L, Rosamilia M, Potter K, Moore K, Atkins S, Rosenfeld J, Birjiniuk A, Jones E, Howard T, Kim J, Scott D, Lalani S, Rouzbehani O, Kaplan S, Hathaway M, Cohen J, Asaki S, Martinez H, Boudina S, Landstrom A. PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study. Circulation Genomic And Precision Medicine 2023, 16: 390-400. PMID: 37395136, PMCID: PMC10528350, DOI: 10.1161/circgen.122.003912.Peer-Reviewed Original ResearchConceptsConditional knockout miceKnockout miceCardiac transplantationCardiac mortalityRetrospective cohortIncreased risk of cardiomyopathyVentricular assist deviceDeletion syndromeAssociated with increased risk of deathMulti-institutional cohort studyReview cohortPediatric-onset cardiomyopathiesAssociated with increased riskRisk of cardiomyopathyPrevalence of cardiomyopathyRisk of deathSeverity of contractile dysfunctionPrognostic impactAssess fibrosisContractile dysfunctionCohort studyCardiomyopathyCardiac diseaseIncreased riskAssist deviceASO Visual Abstract: Trends in Receipt of Adjuvant Chemotherapy and Impact on Survival in Resected Biliary Tract Cancers
Rhodin K, Liu A, Bartholomew A, Kramer R, Parameswaran A, Uronis H, Strickler J, Hsu D, Morse M, Shah K, Herbert G, Zani S, Nussbaum D, Allen P, Lidsky M. ASO Visual Abstract: Trends in Receipt of Adjuvant Chemotherapy and Impact on Survival in Resected Biliary Tract Cancers. Annals Of Surgical Oncology 2023, 30: 4824-4825. DOI: 10.1245/s10434-023-13637-7.Peer-Reviewed Original ResearchTrends in Receipt of Adjuvant Chemotherapy and its Impact on Survival in Resected Biliary Tract Cancers
Rhodin K, Liu A, Bartholomew A, Kramer R, Parameswaran A, Uronis H, Strickler J, Hsu D, Morse M, Shah K, Herbert G, Zani S, Nussbaum D, Allen P, Lidsky M. Trends in Receipt of Adjuvant Chemotherapy and its Impact on Survival in Resected Biliary Tract Cancers. Annals Of Surgical Oncology 2023, 30: 4813-4821. PMID: 37188803, PMCID: PMC10330866, DOI: 10.1245/s10434-023-13567-4.Peer-Reviewed Original ResearchConceptsBiliary tract cancerResected biliary tract cancerNational Cancer DatabaseAdjuvant chemotherapyGallbladder cancerIntrahepatic CCAExtrahepatic CCAMethodsThe National Cancer DatabaseMultivariate Cox proportional hazards methodBiliary tract cancer subtypesOdds of ACCox proportional hazards methodReceipt of adjuvant chemotherapyCurative-intent treatmentReceipt of ACFactors associated with receiptYear of diagnosisHigher comorbidity scoreProportional hazards methodStage of diseaseFactors associated with ACMultivariate logistic regressionAssociated with reduced oddsIII diseasePositive margins
2021
One gene, two modes of inheritance, four diseases: A systematic review of the cardiac manifestation of pathogenic variants in JPH2-encoded junctophilin-2
Parker L, Kramer R, Kaplan S, Landstrom A. One gene, two modes of inheritance, four diseases: A systematic review of the cardiac manifestation of pathogenic variants in JPH2-encoded junctophilin-2. Trends In Cardiovascular Medicine 2021, 33: 1-10. PMID: 34861382, PMCID: PMC9156715, DOI: 10.1016/j.tcm.2021.11.006.Peer-Reviewed Original ResearchConceptsSudden cardiac deathDilated cardiomyopathyHypertrophic cardiomyopathyCardiac diseaseMode of inheritanceEarly onset DCMCardiac conduction diseaseVariant-positive individualsLoss-of-function variantsCorrelated clinical phenotypesDominant missense variantsSystematic reviewCardiac manifestationsConduction diseaseCase reportCardiac deathPathogenic variantsClinical phenotypeMissense variantsJPH2Rare variantsDiseaseCardiomyopathyArrhythmiasVariants
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