News
Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex–Mediated Activation of the NLRP3 Inflammasome
Macrophage migration inhibitory factor (MIF), produced primarily from activated monocytes and macrophages, is an upstream activator of innate immune responses (1–3). In addition to its inhibition of monocyte migration and macrophage mobility, MIF promotes inflammatory responses by counter-regulating thinhibitory effect of glucocorticoids on the production of inflam- matory cytokines from macrophages, and by suppressing p53- dependent cell death (4,5). The MIF receptor complex is com- posed of the transmembrane ligand-binding component CD74 and the CD44 signaling component (6,7). MIF also competes with cognate ligands for CXCR4 and CXCR2, and directly binds to CXCR2 in a macromolecular receptor complex with CD74 (8).
Source: Arthritis & Rheumatology